Hmdb loader

Showing Protein Carboxypeptidase A6 (HMDBP10013)

IdentificationBiological propertiesGene propertiesProtein propertiesExternal linksReferencesXMLShow 2 metabolites
Identification
HMDB Protein ID HMDBP10013
Secondary Accession Numbers
  • 15951
Name Carboxypeptidase A6
Synonyms
  1. Carboxypeptidase B
Gene Name CPA6
Protein Type Enzyme
Biological Properties
General Function Involved in metallocarboxypeptidase activity
Specific Function Release of a C-terminal amino acid, but little or no action with -Asp, -Glu, -Arg, -Lys or -Pro
Pathways Not Available
Reactions Not Available
GO Classification
Function
exopeptidase activity
ion binding
cation binding
metal ion binding
binding
catalytic activity
hydrolase activity
transition metal ion binding
zinc ion binding
metallocarboxypeptidase activity
carboxypeptidase activity
peptidase activity
peptidase activity, acting on l-amino acid peptides
Process
metabolic process
macromolecule metabolic process
protein metabolic process
proteolysis
Cellular Location
  1. Secreted
Gene Properties
Chromosome Location Chromosome:8
Locus 8q13.2
SNPs CPA6
Gene Sequence 
>1314 bp
ATGAAGTGTCTCGGGAAGCGCAGGGGCCAGGCAGCTGCTTTCCTGCCTCTTTGCTGGCTC
TTTTTGAAGATTCTGCAACCGGGGCACAGCCACCTTTATAACAACCGCTATGCTGGTGAT
AAAGTGATAAGATTTATTCCCAAAACAGAAGAGGAAGCATATGCACTGAAGAAAATATCC
TATCAACTTAAGGTGGACCTGTGGCAGCCCAGCAGTATCTCCTATGTATCAGAGGGAACA
GTTACTGATGTCCATATCCCCCAAAATGGTTCCCGAGCCCTGTTAGCCTTCTTACAGGAA
GCCAACATCCAGTACAAGGTCCTCATAGAAGATCTTCAGAAAACACTGGAGAAGGGAAGC
AGCTTGCACACCCAGAGAAACCGAAGATCCCTCTCTGGATATAATTATGAAGTTTATCAC
TCCTTAGAAGAAATTCAAAATTGGATGCATCATCTGAATAAAACTCACTCAGGCCTCATT
CACATGTTCTCTATTGGAAGATCATATGAGGGAAGATCTCTTTTTATTTTAAAGCTGGGC
AGACGATCACGACTCAAAAGAGCTGTTTGGATAGACTGTGGTATTCATGCAAGAGAATGG
ATTGGTCCTGCCTTTTGTCAGTGGTTTGTAAAAGAAGCTCTTCTAACATATAAGAGTGAC
CCAGCCATGAGAAAAATGTTGAATCATCTATATTTCTATATCATGCCTGTGTTTAACGTC
GATGGATACCATTTTAGTTGGACCAATGATCGATTTTGGAGAAAAACAAGGTCAAGGAAC
TCAAGGTTTCGCTGCCGTGGAGTGGATGCCAATAGAAACTGGAAAGTGAAGTGGTGTGAT
GAAGGAGCTTCTATGCACCCTTGTGATGACACATACTGTGGCCCTTTTCCAGAATCTGAG
CCGGAAGTGAAGGCTGTAGCTAACTTCCTTCGAAAACACAGAAAGCACATTAGGGCTTAT
CTCTCCTTTCATGCATATGCTCAGATGTTACTGTATCCCTATTCTTACAAATATGCAACA
ATTCCCAATTTTAGATGTGTGGAATCTGCAGCTTATAAAGCTGTGAATGCACTTCAGTCA
GTATACGGGGTACGATACAGATATGGACCAGCCTCCACAACGTTGTATGTGAGCTCTGGT
AGCTCAATGGATTGGGCCTACAAAAATGGAATACCTTATGCATTTGCTTTCGAACTACGT
GACACTGGATATTTTGGATTTTTACTCCCAGAGATGCTCATCAAACCCACCTGTACAGAA
ACTATGCTGGCTGTGAAAAATATCACAATGCACCTGCTAAAGAAATGTCCCTGA
Protein Properties
Number of Residues 437
Molecular Weight 51007.5
Theoretical pI 9.89
Pfam Domain Function
Signals
  • 1-30
Transmembrane Regions
  • None
Protein Sequence 
>Carboxypeptidase A6
MKCLGKRRGQAAAFLPLCWLFLKILQPGHSHLYNNRYAGDKVIRFIPKTEEEAYALKKIS
YQLKVDLWQPSSISYVSEGTVTDVHIPQNGSRALLAFLQEANIQYKVLIEDLQKTLEKGS
SLHTQRNRRSLSGYNYEVYHSLEEIQNWMHHLNKTHSGLIHMFSIGRSYEGRSLFILKLG
RRSRLKRAVWIDCGIHAREWIGPAFCQWFVKEALLTYKSDPAMRKMLNHLYFYIMPVFNV
DGYHFSWTNDRFWRKTRSRNSRFRCRGVDANRNWKVKWCDEGASMHPCDDTYCGPFPESE
PEVKAVANFLRKHRKHIRAYLSFHAYAQMLLYPYSYKYATIPNFRCVESAAYKAVNALQS
VYGVRYRYGPASTTLYVSSGSSMDWAYKNGIPYAFAFELRDTGYFGFLLPEMLIKPTCTE
TMLAVKNITMHLLKKCP
GenBank ID Protein 188536067
UniProtKB/Swiss-Prot ID Q8N4T0
UniProtKB/Swiss-Prot Entry Name CBPA6_HUMAN
PDB IDs Not Available
GenBank Gene ID NM_020361.4
GeneCard ID CPA6
GenAtlas ID CPA6
HGNC ID HGNC:17245
References
General References
  1. Gerhard DS, Wagner L, Feingold EA, Shenmen CM, Grouse LH, Schuler G, Klein SL, Old S, Rasooly R, Good P, Guyer M, Peck AM, Derge JG, Lipman D, Collins FS, Jang W, Sherry S, Feolo M, Misquitta L, Lee E, Rotmistrovsky K, Greenhut SF, Schaefer CF, Buetow K, Bonner TI, Haussler D, Kent J, Kiekhaus M, Furey T, Brent M, Prange C, Schreiber K, Shapiro N, Bhat NK, Hopkins RF, Hsie F, Driscoll T, Soares MB, Casavant TL, Scheetz TE, Brown-stein MJ, Usdin TB, Toshiyuki S, Carninci P, Piao Y, Dudekula DB, Ko MS, Kawakami K, Suzuki Y, Sugano S, Gruber CE, Smith MR, Simmons B, Moore T, Waterman R, Johnson SL, Ruan Y, Wei CL, Mathavan S, Gunaratne PH, Wu J, Garcia AM, Hulyk SW, Fuh E, Yuan Y, Sneed A, Kowis C, Hodgson A, Muzny DM, McPherson J, Gibbs RA, Fahey J, Helton E, Ketteman M, Madan A, Rodrigues S, Sanchez A, Whiting M, Madari A, Young AC, Wetherby KD, Granite SJ, Kwong PN, Brinkley CP, Pearson RL, Bouffard GG, Blakesly RW, Green ED, Dickson MC, Rodriguez AC, Grimwood J, Schmutz J, Myers RM, Butterfield YS, Griffith M, Griffith OL, Krzywinski MI, Liao N, Morin R, Palmquist D, Petrescu AS, Skalska U, Smailus DE, Stott JM, Schnerch A, Schein JE, Jones SJ, Holt RA, Baross A, Marra MA, Clifton S, Makowski KA, Bosak S, Malek J: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). Genome Res. 2004 Oct;14(10B):2121-7. [PubMed:15489334 ]
  2. Gauci S, Helbig AO, Slijper M, Krijgsveld J, Heck AJ, Mohammed S: Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach. Anal Chem. 2009 Jun 1;81(11):4493-501. doi: 10.1021/ac9004309. [PubMed:19413330 ]
  3. Wei S, Segura S, Vendrell J, Aviles FX, Lanoue E, Day R, Feng Y, Fricker LD: Identification and characterization of three members of the human metallocarboxypeptidase gene family. J Biol Chem. 2002 Apr 26;277(17):14954-64. Epub 2002 Feb 8. [PubMed:11836249 ]
  4. Pizzuti A, Calabrese G, Bozzali M, Telvi L, Morizio E, Guida V, Gatta V, Stuppia L, Ion A, Palka G, Dallapiccola B: A peptidase gene in chromosome 8q is disrupted by a balanced translocation in a duane syndrome patient. Invest Ophthalmol Vis Sci. 2002 Dec;43(12):3609-12. [PubMed:12454025 ]