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Identification
HMDB Protein ID HMDBP10106
Secondary Accession Numbers
  • 16057
Name D-dopachrome decarboxylase
Synonyms
  1. D-dopachrome tautomerase
  2. Phenylpyruvate tautomerase II
Gene Name DDT
Protein Type Enzyme
Biological Properties
General Function Involved in D-dopachrome decarboxylase activity
Specific Function Tautomerization of D-dopachrome with decarboxylation to give 5,6-dihydroxyindole (DHI).
Pathways Not Available
Reactions
D-Dopachrome → 5,6-Dihydroxyindole + CO(2) details
GO Classification
Biological Process
melanin biosynthetic process
Cellular Component
cytoplasm
Molecular Function
D-dopachrome decarboxylase activity
dopachrome isomerase activity
Cellular Location
  1. Cytoplasm
Gene Properties
Chromosome Location 22
Locus 22q11.23
SNPs DDT
Gene Sequence
>357 bp
ATGCCGTTCCTGGAGCTGGACACGAATTTGCCCGCCAACCGAGTGCCCGCGGGGCTGGAG
AAACGACTCTGCGCCGCCGCTGCCTCCATCCTGGGCAAACCTGCGGACCGCGTGAACGTG
ACGGTACGGCCGGGCCTGGCCATGGCGCTGAGCGGGTCCACCGAGCCCTGCGCGCAGCTG
TCCATCTCCTCCATCGGCGTAGTGGGCACCGCCGAGGACAACCGCAGCCACAGCGCCCAC
TTCTTTGAGTTTCTCACCAAGGAGCTAGCCCTGGGCCAGGACCGGATACTTATCCGCTTT
TTCCCCTTGGAGTCCTGGCAGATTGGCAAGATAGGGACGGTCATGACTTTTTTATGA
Protein Properties
Number of Residues 118
Molecular Weight 12711.605
Theoretical pI 7.295
Pfam Domain Function
Signals Not Available
Transmembrane Regions Not Available
Protein Sequence
>D-dopachrome decarboxylase
MPFLELDTNLPANRVPAGLEKRLCAAAASILGKPADRVNVTVRPGLAMALSGSTEPCAQL
SISSIGVVGTAEDNRSHSAHFFEFLTKELALGQDRILIRFFPLESWQIGKIGTVMTFL
GenBank ID Protein 2352915
UniProtKB/Swiss-Prot ID P30046
UniProtKB/Swiss-Prot Entry Name DOPD_HUMAN
PDB IDs
GenBank Gene ID AF012434
GeneCard ID DDT
GenAtlas ID DDT
HGNC ID HGNC:2732
References
General References
  1. Gerhard DS, Wagner L, Feingold EA, Shenmen CM, Grouse LH, Schuler G, Klein SL, Old S, Rasooly R, Good P, Guyer M, Peck AM, Derge JG, Lipman D, Collins FS, Jang W, Sherry S, Feolo M, Misquitta L, Lee E, Rotmistrovsky K, Greenhut SF, Schaefer CF, Buetow K, Bonner TI, Haussler D, Kent J, Kiekhaus M, Furey T, Brent M, Prange C, Schreiber K, Shapiro N, Bhat NK, Hopkins RF, Hsie F, Driscoll T, Soares MB, Casavant TL, Scheetz TE, Brown-stein MJ, Usdin TB, Toshiyuki S, Carninci P, Piao Y, Dudekula DB, Ko MS, Kawakami K, Suzuki Y, Sugano S, Gruber CE, Smith MR, Simmons B, Moore T, Waterman R, Johnson SL, Ruan Y, Wei CL, Mathavan S, Gunaratne PH, Wu J, Garcia AM, Hulyk SW, Fuh E, Yuan Y, Sneed A, Kowis C, Hodgson A, Muzny DM, McPherson J, Gibbs RA, Fahey J, Helton E, Ketteman M, Madan A, Rodrigues S, Sanchez A, Whiting M, Madari A, Young AC, Wetherby KD, Granite SJ, Kwong PN, Brinkley CP, Pearson RL, Bouffard GG, Blakesly RW, Green ED, Dickson MC, Rodriguez AC, Grimwood J, Schmutz J, Myers RM, Butterfield YS, Griffith M, Griffith OL, Krzywinski MI, Liao N, Morin R, Palmquist D, Petrescu AS, Skalska U, Smailus DE, Stott JM, Schnerch A, Schein JE, Jones SJ, Holt RA, Baross A, Marra MA, Clifton S, Makowski KA, Bosak S, Malek J: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). Genome Res. 2004 Oct;14(10B):2121-7. [PubMed:15489334 ]
  2. Hochstrasser DF, Frutiger S, Paquet N, Bairoch A, Ravier F, Pasquali C, Sanchez JC, Tissot JD, Bjellqvist B, Vargas R, et al.: Human liver protein map: a reference database established by microsequencing and gel comparison. Electrophoresis. 1992 Dec;13(12):992-1001. [PubMed:1286669 ]
  3. Dunham I, Shimizu N, Roe BA, Chissoe S, Hunt AR, Collins JE, Bruskiewich R, Beare DM, Clamp M, Smink LJ, Ainscough R, Almeida JP, Babbage A, Bagguley C, Bailey J, Barlow K, Bates KN, Beasley O, Bird CP, Blakey S, Bridgeman AM, Buck D, Burgess J, Burrill WD, O'Brien KP, et al.: The DNA sequence of human chromosome 22. Nature. 1999 Dec 2;402(6761):489-95. [PubMed:10591208 ]
  4. Gevaert K, Goethals M, Martens L, Van Damme J, Staes A, Thomas GR, Vandekerckhove J: Exploring proteomes and analyzing protein processing by mass spectrometric identification of sorted N-terminal peptides. Nat Biotechnol. 2003 May;21(5):566-9. Epub 2003 Mar 31. [PubMed:12665801 ]
  5. Collins JE, Wright CL, Edwards CA, Davis MP, Grinham JA, Cole CG, Goward ME, Aguado B, Mallya M, Mokrab Y, Huckle EJ, Beare DM, Dunham I: A genome annotation-driven approach to cloning the human ORFeome. Genome Biol. 2004;5(10):R84. Epub 2004 Sep 30. [PubMed:15461802 ]
  6. Nishihira J, Fujinaga M, Kuriyama T, Suzuki M, Sugimoto H, Nakagawa A, Tanaka I, Sakai M: Molecular cloning of human D-dopachrome tautomerase cDNA: N-terminal proline is essential for enzyme activation. Biochem Biophys Res Commun. 1998 Feb 13;243(2):538-44. [PubMed:9480844 ]
  7. Esumi N, Budarf M, Ciccarelli L, Sellinger B, Kozak CA, Wistow G: Conserved gene structure and genomic linkage for D-dopachrome tautomerase (DDT) and MIF. Mamm Genome. 1998 Sep;9(9):753-7. [PubMed:9716662 ]
  8. Sugimoto H, Taniguchi M, Nakagawa A, Tanaka I, Suzuki M, Nishihira J: Crystal structure of human D-dopachrome tautomerase, a homologue of macrophage migration inhibitory factor, at 1.54 A resolution. Biochemistry. 1999 Mar 16;38(11):3268-79. [PubMed:10079069 ]