Hmdb loader
Identification
HMDB Protein ID HMDBP10116
Secondary Accession Numbers
  • 16071
Name Ubiquitin carboxyl-terminal hydrolase 47
Synonyms
  1. Deubiquitinating enzyme 47
  2. Ubiquitin thiolesterase 47
  3. Ubiquitin-specific-processing protease 47
Gene Name USP47
Protein Type Enzyme
Biological Properties
General Function Involved in ubiquitin thiolesterase activity
Specific Function Putative ubiquitin-specific-processing protease that regulates cell growth and survival. Probably regulates CDC25A expression at a transcriptional level. May be catalytically inactive although it seems to have kept all necessary active site residues
Pathways Not Available
Reactions Not Available
GO Classification
Function
hydrolase activity, acting on ester bonds
catalytic activity
hydrolase activity
ubiquitin thiolesterase activity
thiolester hydrolase activity
Process
metabolic process
catabolic process
macromolecule catabolic process
cellular macromolecule catabolic process
modification-dependent macromolecule catabolic process
modification-dependent protein catabolic process
ubiquitin-dependent protein catabolic process
Cellular Location
  1. Cytoplasmic
Gene Properties
Chromosome Location Chromosome:1
Locus 11p15.3
SNPs USP47
Gene Sequence
>3864 bp
ATGGTGCCCGGCGAGGAGAACCAACTGGTCCCGAAAGAGGCACCACTGGATCATACCAGT
GACAAGTCACTTCTCGACGCTAATTTTGAGCCAGGAAAGAAGAACTTTCTGCATTTGACA
GATAAAGATGGTGAACAACCTCAAATACTGCTGGAGGATTCCAGTGCTGGGGAAGACAGT
GTTCATGACAGGTTTATAGGTCCGCTTCCAAGAGAAGGTTCTGGGGGTTCTACCAGTGAT
TATGTCAGCCAAAGCTACTCCTACTCATCTATTTTGAATAAATCAGAAACTGGATATGTG
GGACTAGTAAACCAAGCAATGACTTGCTATTTGAATAGCCTTTTGCAAACACTTTTTATG
ACTCCTGAATTTAGGAATGCATTATATAAGTGGGAATTTGAAGAATCTGAAGAAGATCCA
GTGACAAGTATTCCATACCAACTTCAAAGGCTTTTTGTTTTGTTACAAACCAGCAAAAAG
AGAGCAATTGAAACCACAGATGTTACAAGGAGCTTTGGATGGGATAGTAGTGAGGCTTGG
CAGCAGCATGATGTACAAGAACTATGCAGAGTCATGTTTGATGCTTTGGAACAGAAATGG
AAGCAAACAGAACAGGCTGATCTTATAAATGAGCTATATCAAGGCAAGCTGAAGGACTAC
GTGAGATGTCTGGAATGTGGTTATGAGGGCTGGCGAATCGACACATATCTTGATATTCCA
TTGGTCATCCGACCTTATGGGTCCAGCCAAGCATTTGCTAGTGTGGAAGAAGCATTGCAT
GCATTTATTCAGCCAGAGATTCTGGATGGCCCAAATCAGTATTTTTGTGAACGTTGTAAG
AAGAAGTGTGATGCACGGAAGGGCCTTCGGTTTTTGCATTTTCCTTATCTGCTGACCTTA
CAGCTGAAAAGATTCGATTTTGATTATACAACCATGCATAGGATTAAACTGAATGATCGA
ATGACATTTCCCGAGGAACTAGATATGAGTACTTTTATTGATGTTGAAGATGAGAAATCT
CCTCAGACTGAAAGTTGCACTGACAGTGGAGCAGAAAATGAAGGTAGTTGTCACAGTGAT
CAGATGAGCAACGATTTCTCCAATGATGATGGTGTTGATGAAGGAATCTGTCTTGAAACC
AATAGTGGAACTGAAAAGATCTCAAAATCTGGACTTGAAAAGAATTCCTTGATCTATGAA
CTTTTCTCTGTTATGGTTCATTCTGGGAGCGCTGCTGGTGGTCATTATTATGCATGTATA
AAGTCATTCAGTGATGAGCAGTGGTACAGCTTCAATGATCAACATGTCAGCAGGATAACA
CAAGAGGACATTAAGAAAACACATGGTGGATCTTCAGGAAGCAGAGGATATTATTCTAGT
GCTTTCGCAAGTTCCACAAATGCATATATGCTGATCTATAGACTGAAGGATCCAGCCAGA
AATGCAAAATTTCTAGAAGTGGATGAATACCCAGAACATATTAAAAACTTGGTGCAGAAA
GAGAGAGAGTTGGAAGAACAAGAAAAGAGACAACGAGAAATTGAGCGCAATACATGCAAG
ATAAAATTATTCTGTTTGCATCCTACAAAACAAGTAATGATGGAAAATAAATTGGAGGTT
CATAAGGATAAGACATTAAAGGAAGCAGTAGAAATGGCTTATAAGATGATGGATTTAGAA
GAGGTAATACCCCTGGATTGCTGTCGCCTTGTTAAATATGATGAGTTTCATGATTATCTA
GAACGGTCATATGAAGGAGAAGAAGATACACCAATGGGGCTTCTACTAGGTGGCGTCAAG
TCAACATATATGTTTGATCTGCTGTTGGAGACGAGAAAGCCTGATCAGGTTTTCCAATCT
TATAAACCTGGAGAAGTGATGGTGAAAGTTCATGTTGTTGATCTAAAGGCAGAATCTGTA
GCTGCTCCTATAACTGTTCGTGCTTACTTAAATCAGACAGTTACAGAATTCAAACAACTG
ATTTCAAAGGCCATCCATTTACCTGCTGAAACAATGAGAATAGTGCTGGAACGCTGCTAC
AATGATTTGCGTCTTCTCAGTGTCTCCAGTAAAACCCTGAAAGCTGAAGGATTTTTTAGA
AGTAACAAGGTGTTTGTTGAAAGCTCCGAGACTTTGGATTACCAGATGGCCTTTGCAGAC
TCTCATTTATGGAAACTCCTGGATCGGCATGCAAATACAATCAGATTATTTGTTTTGCTA
CCTGAACAATCCCCAGTATCTTATTCCAAAAGGACAGCATACCAGAAAGCTGGAGGCGAT
TCTGGTAATGTGGATGATGACTGTGAAAGAGTCAAAGGACCTGTAGGAAGCCTAAAGTCT
GTGGAAGCTATTCTAGAAGAAAGCACTGAAAAACTCAAAAGCTTGTCACTGCAGCAACAG
CAGGATGGAGATAATGGGGACAGCAGCAAAAGTACTGAGACAAGTGACTTTGAAAACATC
GAATCACCTCTCAATGAGAGGGACTCTTCAGCATCAGTGGATAATAGAGAACTTGAACAG
CATATTCAGACTTCTGATCCAGAAAATTTTCAGTCTGAAGAACGATCAGACTCAGATGTG
AATAATGACAGGAGTACAAGTTCAGTGGACAGTGATATTCTTAGCTCCAGTCATAGCAGT
GATACTTTGTGCAATGCAGACAATGCTCAGATCCCTTTGGCTAATGGACTTGACTCTCAC
AGTATCACAAGTAGTAGAAGAACGAAAGCAAATGAAGGGAAAAAAGAAACATGGGATACA
GCAGAAGAAGACTCTGGAACTGATAGTGAATATGATGAGAGTGGCAAGAGTAGGGGAGAA
ATGCAGTACATGTATTTCAAAGCTGAACCTTATGCTGCAGATGAAGGTTCTGGGGAAGGA
CATAAATGGTTGATGGTGCATGTTGATAAAAGAATTACTCTGGCAGCTTTCAAACAACAT
TTAGAGCCCTTTGTTGGAGTTTTGTCCTCTCACTTCAAGGTCTTTCGAGTGTATGCCAGC
AATCAAGAGTTTGAGAGCGTCCGGCTGAATGAGACACTTTCATCATTTTCTGATGACAAT
AAGATTACAATTAGACTGGGGAGAGCACTTAAAAAAGGAGAATACAGAGTTAAAGTATAC
CAGCTTTTGGTCAATGAACAAGAGCCATGCAAGTTTCTGCTAGATGCTGTGTTTGCTAAA
GGAATGACTGTACGGCAATCAAAAGAGGAATTAATTCCTCAGCTCAGGGAGCAATGTGGT
TTAGAGCTCAGTATTGACAGGTTTCGTCTAAGGAAAAAAACATGGAAGAATCCTGGCACT
GTCTTTTTGGATTATCATATTTATGAAGAAGATATTAATATTTCCAGCAACTGGGAGGTT
TTCCTTGAAGTTCTTGATGGGGTAGAGAAGATGAAGTCCATGTCACAGCTTGCAGTTTTG
TCAAGACGGTGGAAGCCTTCAGAGATGAAGTTGGATCCCTTCCAGGAGGTTGTATTGGAA
AGCAGTAGTGTGGACGAATTGCGAGAGAAGCTTAGTGAAATCAGTGGGATTCCTTTGGAT
GATATTGAATTTGCTAAGGGTAGAGGAACATTTCCCTGTGATATTTCTGTCCTTGATATT
CATCAGGATTTAGACTGGAATCCTAAAGTTTCTACCCTGAATGTCTGGCCTCTTTATATC
TGTGATGATGGTGCGGTCATATTTTATAGGGATAAAACAGAAGAATTAATGGAATTGACA
GATGAGCAAAGAAATGAACTGATGAAAAAAGAAAGCAGTCGACTCCAGAAGACTGGACAT
CGTGTAACATACTCACCTCGTAAAGAGAAAGCACTAAAAATATATCTGGATGGAGCACCA
AATAAAGATCTGACTCAAGACTGA
Protein Properties
Number of Residues 1375
Molecular Weight 157266.9
Theoretical pI 4.72
Pfam Domain Function
Signals
  • None
Transmembrane Regions
  • None
Protein Sequence
>Ubiquitin carboxyl-terminal hydrolase 47
MVPGEENQLVPKEDVFWRCRQNIFDEMKKKFLQIENAAEEPRVLCIIQDTTNSKTVNERI
TLNLPASTPVRKLFEDVANKVGYINGTFDLVWGNGINTADMAPLDHTSDKSLLDANFEPG
KKNFLHLTDKDGEQPQILLEDSSAGEDSVHDRFIGPLPREGSVGSTSDYVSQSYSYSSIL
NKSETGYVGLVNQAMTCYLNSLLQTLFMTPEFRNALYKWEFEESEEDPVTSIPYQLQRLF
VLLQTSKKRAIETTDVTRSFGWDSSEAWQQHDVQELCRVMFDALEQKWKQTEQADLINEL
YQGKLKDYVRCLECGYEGWRIDTYLDIPLVIRPYGSSQAFASVEEALHAFIQPEILDGPN
QYFCERCKKKCDARKGLRFLHFPYLLTLQLKRFDFDYTTMHRIKLNDRMTFPEELDMSTF
IDVEDEKSPQTESCTDSGAENEGSCHSDQMSNDFSNDDGVDEGICLETNSGTEKISKSGL
EKNSLIYELFSVMAHSGSAAGGHYYACIKSFSDEQWYSFDDQHVSRITQEDIKKTHGGSS
GSRGYYSSAFASSTNAYMLIYRLKDPARNAKFLEVGEYPEHIKNLVQKERELEEQEKRQR
EIERNTCKIKLFCLHPTKQVMMENKLEVHKDKTLKEAVEMAYKMMDLEEVIPLDCCRLVK
YDEFHDYLERSYEGEEDTPMGLLLGGVKSTYMFDLLLETRKPDQVFQSYKPGEVMVKVHV
VDLKAESVAAPITVRAYLNQTVTEFKQLISKAIHLPAETMRIVLERCYNDLRLLSVSSKT
LKAEGFFRSNKVFVESSETLDYQMAFADSHLWKLLDRHANTIRLFVLLPEQSPVSYSKRT
AYQKAGGDSGNVDDDCERVKGPVGSLKSVEAILEESTEKLKSLSLQQQQDGDNGDSSKST
ETSDFENIESPLNERDSSASVDNRELEQHIQTSDPENFQSEERSDSDVNNDRSTSSVDSD
ILSSSHSSDTLCNADNAQIPLANGLDSHSITSSRRTKANEGKKETWDTAEEDSGTDSEYD
ESGKSRGEMQYMYFKAEPYAADEGSGEGHKWLMVHVDKRITLAAFKQHLEPFVGVLSSHF
KVFRVYASNQEFESVRLNETLSSFSDDNKITIRLGRALKKGEYRVKVYQLLVNEQEPCKF
LLDAVFAKGMTVRQSKEELIPQLREQCGLELSIDRFRLRKKTWKNPGTVFLDYHIYEEDI
NISSNWEVFLEVLDGVEKMKSMSQLAVLSRRWKPSEMKLDPFQEVVLESSSVDELREKLS
EISGIPLDDIEFAKGRGTFPCDISVLDIHQDLDWNPKVSTLNVWPLYICDDGAVIFYRDK
TEELMELTDEQRNELMKKESSRLQKTGHRVTYSPRKEKALKIYLDGAPNKDLTQD
GenBank ID Protein 71774197
UniProtKB/Swiss-Prot ID Q96K76
UniProtKB/Swiss-Prot Entry Name UBP47_HUMAN
PDB IDs Not Available
GenBank Gene ID Not Available
GeneCard ID USP47
GenAtlas ID USP47
HGNC ID HGNC:20076
References
General References
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  3. Choudhary C, Kumar C, Gnad F, Nielsen ML, Rehman M, Walther TC, Olsen JV, Mann M: Lysine acetylation targets protein complexes and co-regulates major cellular functions. Science. 2009 Aug 14;325(5942):834-40. doi: 10.1126/science.1175371. Epub 2009 Jul 16. [PubMed:19608861 ]
  4. Dephoure N, Zhou C, Villen J, Beausoleil SA, Bakalarski CE, Elledge SJ, Gygi SP: A quantitative atlas of mitotic phosphorylation. Proc Natl Acad Sci U S A. 2008 Aug 5;105(31):10762-7. doi: 10.1073/pnas.0805139105. Epub 2008 Jul 31. [PubMed:18669648 ]
  5. Mayya V, Lundgren DH, Hwang SI, Rezaul K, Wu L, Eng JK, Rodionov V, Han DK: Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions. Sci Signal. 2009 Aug 18;2(84):ra46. doi: 10.1126/scisignal.2000007. [PubMed:19690332 ]
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  9. Gauci S, Helbig AO, Slijper M, Krijgsveld J, Heck AJ, Mohammed S: Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach. Anal Chem. 2009 Jun 1;81(11):4493-501. doi: 10.1021/ac9004309. [PubMed:19413330 ]
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