Human Metabolome Database: Showing Protein Probable ubiquitin carboxyl-terminal hydrolase FAF-Y (HMDBP10127)

Identification Biological properties Gene properties Protein properties External links References XML Show 2 metabolites

Identification

HMDB Protein ID

HMDBP10127

Secondary Accession Numbers

16083

Name

Probable ubiquitin carboxyl-terminal hydrolase FAF-Y

Synonyms

Deubiquitinating enzyme FAF-Y
Fat facets protein-related, Y-linked
Ubiquitin thiolesterase FAF-Y
Ubiquitin-specific protease 9, Y chromosome
Ubiquitin-specific-processing protease FAF-Y

Gene Name

USP9Y

Protein Type

Enzyme

Biological Properties

General Function

Involved in binding

Specific Function

May function as a ubiquitin-protein or polyubiquitin hydrolase involved both in the processing of ubiquitin precursors and of ubiquitinated proteins. May therefore play an important role regulatory role at the level of protein turnover by preventing degradation of proteins through the removal of conjugated ubiquitin. Essential component of TGF-beta/BMP signaling cascade. Deubiquitinates monoubiquitinated SMAD4, opposing the activity of E3 ubiquitin-protein ligase TRIM33. Monoubiquitination of SMAD4 hampers its ability to form a stable complex with activated SMAD2/3 resulting in inhibition of TGF- beta/BMP signaling cascade. Deubiqitination of SMAD4 by USP9X re- empowers its competence to mediate TGF-beta signaling

Pathways

Not Available

Reactions

Not Available

GO Classification

Function
hydrolase activity, acting on ester bonds
catalytic activity
hydrolase activity
ubiquitin thiolesterase activity
thiolester hydrolase activity
Process
metabolic process
catabolic process
macromolecule catabolic process
cellular macromolecule catabolic process
modification-dependent macromolecule catabolic process
modification-dependent protein catabolic process
ubiquitin-dependent protein catabolic process

Cellular Location

Cytoplasm

Gene Properties

Chromosome Location

Not Available

Locus

Not Available

SNPs

USP9Y

Gene Sequence

>7668 bp
ATGACAGCCATCACTCATGGCTCTCCAGTAGGAGGGAACGACAGCCAGGGCCAGGTTCTT
GATGGCCAGTCTCAGCATCTCTTCCAACAGAACCAGACTTCATCACCTGATTCTTCCAAT
GAGAATTCCGTAGCAACTCCTCCTCCAGAGGAACAAGGGCAAGGTGATGCCCCACCACAG
CATGAAGATGAAGAGCCTGCATTTCCACATACTGAGCTGGCAAACCTGGATGACATGATC
AACAGGCCTCGATGGGTGGTTCCTGTTTTGCCAAAAGGGGAATTAGAAGTGCTTTTAGAA
GCTGCTATTGATCTTAGTGTAAAAGGCCTTGATGTTAAAAGTGAAGCATGCCAACGTTTT
TTTCGAGATGGACTAACAATATCTTTCACTAAAATTCTTATGGATGAGGCTGTGAGTGGC
TGGAAGTTTGAAATTCATAGATGTATTATTAACAATACTCATCGCCTAGTGGAGCTTTGT
GTGGCCAAGTTGTCCCAAGATTGGTTTCCACTTCTAGAACTTCTCGCCATGGCCTTAAAT
CCTCACTGCAAGTTTCATATCTACAATGGTACACGTCCGTGTGAATTAATTTCCTCAAAT
GCTCAGTTGCCTGAAGATGAATTATTTGCTCGTTCTTCAGATCCTCGATCACCAAAAGGT
TGGCTAGTGGATCTCATCAATAAATTTGGCACATTAAATGGGTTCCAGATTTTGCATGAT
CGTTTTTTTAATGGATCAGCATTAAATATTCAAATAATTGCAGCTCTTATTAAACCATTT
GGACAATGCTATGAGTTTCTCAGTCAACATACACTGAAAAAGTACTTCATTCCAGTTATA
GAAATAGTTCCACATTTATTGGAAAACTTAACTGATGAAGAACTGAAAAAGGAGGCAAAG
AATGAAGCCAAAAATGATGCCCTTTCAATGATTATTAAATCTTTGAAGAACTTAGCTTCA
AGAATTTCAGGACAAGATGAGACTATAAAAAATTTGGAAATTTTTAGGTTAAAGATGATA
CTCAGATTGTTGCAAATTTCCTCTTTTAATGGAAAGATGAATGCACTGAATGAAATAAAT
AAGGTTATATCTAGTGTATCATATTATACTCATCGGCATAGTAATCCTGAGGAGGAAGAA
TGGCTGACAGCTGAGCGAATGGCAGAATGGATACAGCAAAATAATATCTTATCCATAGTC
TTGCAAGACAGTCTTCATCAACCACAATATGTAGAAAAGCTAGAGAAAATTCTTCGTTTT
GTGATTAAAGAAAAGGCTCTTACATTACAGGACCTTGATAATATCTGGGCAGCACAGGCA
GGAAAACATGAAGCCATTGTGAAGAATGTACATGATCTGCTAGCAAAGTTGGCTTGGGAT
TTTTCTCCTGGACAACTTGATCATCTTTTTGATTGCTTTAAGGCAAGTTGGACAAATGCA
AGTAAAAAGCAACGTGAAAAGCTCCTTGAGTTGATACGCCGTCTTGCAGAAGATGATAAA
GATGGTGTGATGGCACACAAAGTGTTGAACCTTCTTTGGAACCTGGCTCAGAGTGATGAT
GTGCCTGTAGACATCATGGACCTTGCTCTTAGTGCCCACATAAAAATACTAGATTATAGT
TGTTCCCAGGATCGAGATGCACAGAAGATCCAGTGGATAGATCACTTTATAGAAGAACTT
CGCACAAATGACAAGTGGGTAATTCCTGCTCTGAAACAAATAAGAGAAATTTGTAGTTTG
TTTGGTGAAGCATCTCAAAATTTGAGTCAAACTCAGCGAAGTCCCCACATATTTTATCGC
CATGATTTAATCAACCAGCTTCAACAAAATCATGCTTTAGTTACTTTGGTAGCAGAAAAC
CTTGCAACCTACATGAATAGCATCAGATTGTATGCTGGAGATCATGAAGACTATGATCCA
CAAACAGTGAGGCTTGGAAGTCGATACAGTCATGTTCAAGAAGTTCAAGAACGACTAAAC
TTCCTTAGATTTTTACTGAAGGATGGCCAACTGTGGCTCTGTGCTCCTCAGGCAAAACAA
ATATGGAAGTGCTTAGCAGAAAATGCAGTTTATCTTTGTGATCGTGAAGCCTGTTTTAAG
TGGTATTCCAAGTTAATGGGGGATGAACCAGACTTGGATCCTGATATTAATAAGGACTTC
TTTGAAAGTAATGTACTTCAGCTTGATCCTTCCCTTTTAACTGAAAATGGAATGAAATGC
TTTGAAAGATTTTTCAAAGCTGTCAATTGTCGAGAAAGGAAACTAATAGCAAAAAGAAGA
TCCTATATGATGGATGATTTGGAATTAATTGGACTAGACTACCTTTGGAGGGTTGTGATT
CAGAGTAGTGACGAGATTGCTAACAGAGCTATAGATCTTCTTAAAGAGATATACACAAAC
CTTGGCCCAAGATTAAAAGCCAATCAGGTGGTTATCCATGAAGACTTCATTCAGTCTTGC
TTTGATCGTTTAAAAGCATCATATGATACACTGTGTGTTTTTGATGGTGACAAAAACAGC
ATTAATTGTGCAAGACAAGAAGCCATTCGAATGGTTAGAGTATTAACTGTTATAAAAGAG
TACATTAATGAATGTGACAGTGATTATCACAAGGAAAGAATGATTCTACCTATGTCGAGA
GCATTTCGTGGCAAACACCTCTCTCTTATAGTTCGGTTTCCAAACCAGGGCAGACAGGTT
GATGAGTTGGATATATGGTCTCATACGAATGACACAATTGGTTCAGTACGGCGATGTATT
GTTAATCGTATTAAAGCCAATGTAGCCCACAAAAAAATTGAACTTTTTGTGGGTGGTGAG
CTGATAGATTCTGAAGATGACAGAAAGCTAATTGGACAATTAAACTTAAAAGATAAATCT
CTAATTACAGCCAAACTTACACAAATAAATTTCAATATGCCATCAAGTCCTGATAGCTCT
TCCGATTCCTCAACTGCATCTCCTGGAAACCACCGTAATCATTACAATGATGGTCCCAAT
CTAGAGGTGGAAAGTTGTTTGCCTGGGGTGATAATGTCAGTGCATCCCAGATACATCTCT
TTCCTTTGGCAAGTTGCAGACTTAGGTAGCAACCTGAATATGCCACCTCTTAGAGATGGA
GCAAGAGTACTTATGAAACTTATGCCACCAGATAGAACAGCTGTAGAAAAATTACGAGCT
GTTTGTTTGGACCATGCAAAACTTGGAGAAGGCAAACTTAGTCCACCCCTTGACTCTCTT
TTCTTTGGTCCTTCTGCCTCCCAAGTTCTATACCTAACAGAGGTAGTTTATGCCTTGTTA
ATGCCTGCTGGTGTGCCTCTAACTGATGGGTCCTCTGACTTTCAAGTTCACTTCTTGAAA
AGTGGTGGCTTACCTCTTGTACTGAGTATGCTAATAAGAAATAACTTCTTGCCAAATACA
GATATGGAAACTCGAAGGGGTGCTTATTTAAATGCTCTTAAAATAGCCAAACTGTTGTTA
ACTGCGATTGGCTATGGCCATGTTCGAGCTGTAGCAGAAGCTTGTCAGCCAGTTGTAGAT
GGTACAGACCCCATAACACAGATTAACCAAGTTACTCATGATCAAGCAGTGGTGCTACAA
AGTGCCCTTCAGAGCATTCCTAATCCCTCATCCGAGTGCGTACTTAGAAATGAGTCCATA
CTTCTTGCTCAGGAAATATCTAATGAGGCTTCAAGATATATGCCTGATATTTGTGTAATT
AGGGCTATACAGAAAATTATCTGGGCATCAGCATGTGGGGCATTAGGACTAGTTTTTAGC
CCAAATGAAGAAATAACTAAAATTTATCAGATGACCACCAATGGAAGCAATAAGCTGGAG
GTGGAAGATGAACAAGTTTGCTGTGAAGCACTGGAAGTGATGACCTTATGTTTTGCTTTA
CTTCCAACAGCGTTGGATGCACTTAGTAAAGAAAAAGCCTGGCAGACCTTCATCATTGAC
TTATTATTGCACTGTCCAAGCAAAACTGTTCGTCAGTTGGCACAGGAGCAGTTCTTTTTA
ATGTGCACCAGATGTTGCATGGGACACAGGCCTCTGCTTTTCTTCATTACTTTACTCTTT
ACCATACTGGGGAGCACAGCAAGAGAGAAGGGTAAATATTCAGGTGATTATTTCACACTT
TTACGGCACCTTCTCAATTATGCTTACAATGGCAATATTAACATACCCAATGCTGAAGTT
CTTCTTGTCAGTGAAATTGATTGGCTCAAAAGGATTAGGGATAATGTTAAAAACACAGGT
GAAACAGGTGTCGAAGAGCCAATACTGGAAGGCCACCTTGGGGTAACAAAAGAGTTATTG
GCCTTTCAAACTTCTGAGAAAAAGTATCACTTTGGTTGTGAAAAAGGAGGTGCTAATCTC
ATTAAAGAATTAATTGATGATTTCATCTTTCCCGCATCCAAAGTTTACCTGCAGTATTTA
AGAAGTGGAGAACTACCAGCTGAGCAGGCTATTCCAGTCTGTAGTTCACCCGTTACCATC
AATGCCGGTTTTGAGCTACTTGTAGCATTAGCTATTGGCTGTGTGAGGAATCTCAAACAG
ATAGTAGACTGTTTGACTGAAATGTATTACATGGGCACAGCAATTACTACTTGTGAAGCA
CTTACTGAGTGGGAATATCTGCCCCCTGTTGGACCCCGCCCACCAAAAGGATTTGTGGGA
CTCAAAAATGCTGGTGCTACGTGTTACATGAACTCTGTGATCCAGCAGCTATACATGATT
CCTTCTATCAGGAACAGTATTCTTGCAATTGAAGGCACAGGTAGTGATTTACACGATGAT
ATGTTCGGGGATGAGAAGCAGGACAGTGAGAGTAATGTTGATCCCCGAGATGATGTATTT
GGATATCCTCATCAATTTGAAGACAAGCCAGCATTAAGTAAGACAGAAGATAGGAAAGAG
TATAATATTGGTGTCCTAAGACACCTTCAGGTCATCTTTGGTCATTTAGCTGCTTCCCAA
CTACAATACTATGTACCCAGAGGATTTTGGAAACAGTTCAGGCTTTGGGGTGAACCTGTT
AATCTCCGTGAACAACATGATGCCTTAGAGTTTTTTAATTCTTTGGTGGATAGTTTAGAT
GAAGCTTTAAAAGCTTTAGGACACCCGGCTATACTAAGTAAAGTCCTAGGAGGCTCCTTT
GCTGATCAGAAGATCTGCCAAGGCTGCCCACATAGGTATGAATGTGAAGAATCTTTTACA
ACTTTGAATGTGGATATTAGAAATCATCAAAATCTTCTTGACTCTTTGGAACAGTATATC
AAAGGAGATTTATTGGAAGGTGCAAATGCATATCATTGTGAAAAATGTGATAAAAAGGTT
GACACAGTAAAGCGCCTGCTAATTAAAAAATTGCCTCGGGTTCTTGCTATCCAACTCAAA
CGATTTGACTATGACTGGGAAAGAGAATGTGCAATTAAATTCAATGATTATTTTGAATTT
CCTCGAGAGCTGGATATGGGACCTTACACAGTAGCAGGTGTTGCAAACCTGGAAAGGGAT
AATGTAAACTCAGAAAATGAGTTGATTGAACAGAAAGAGCAGTCTGACAATGAAACTGCA
GGAGGCACAAAGTACAGACTTGTAGGAGTGCTTGTACACAGTGGTCAAGCAAGCGGTGGG
CATTATTATTCTTACATCATTCAAAGGAATGGTAAAGATGATCAGACAGATCACTGGTAT
AAATTTGATGATGGAGATGTAACAGAATGCAAAATGGATGATGATGAAGAAATGAAAAAT
CAGTGTTTTGGTGGAGAGTACATGGGAGAAGTATTTGATCACATGATGAAGCGCATGTCA
TATAGGCGACAGAAGAGGTGGTGGAATGCTTACATACTTTTTTATGAACAAATGGATATG
ATAGATGAAGATGATGAGATGATAAGATACATATCAGAGCTAACTATTGCAAGACCCCAT
CAGATCATTATGTCACCAGCCATTGAGAGAAGTGTACGGAAACAAAATGTGAAATTTATG
CATAACCGATTGCAATATAGTTTAGAGTATTTTCAGTTTGTGAAAAAACTGCTTACATGT
AATGGTGTTTATTTAAACCCTGCTCCAGGGCAGGATTATTTGTTGCCTGAAGCAGAAGAA
ATTACTATGATTAGTATTCAGCTTGCTGCTAGATTCCTCTTTACCACTGGATTTCACACC
AAGAAAATAGTTCGTGGTCCTGCCAGTGACTGGTATGATGCACTGTGCGTTCTTCTCCGT
CACAGCAAAAATGTACGTTTTTGGTTTACTCATAATGTCCTTTTTAATGTATCAAATCGC
TTCTCTGAATACCTTCTGGAGTGCCCTAGTGCAGAAGTGAGGGGTGCATTTGCAAAACTT
ATAGTGTTTATTGCACACTTTTCCTTGCAAGATGGGTCTTGTCCTTCTCCTTTTGCATCT
CCAGGACCTTCTAGTCAGGCATGTGATAACTTGAGCTTGAGTGACCACTTACTAAGAGCC
ACACTAAATCTCTTGAGAAGGGAAGTTTCAGAGCATGGACATCATTTACAGCAATATTTT
AATTTGTTTGTAATGTATGCCAATTTAGGTGTGGCAGAAAAAACACAGCTTCTGAAATTG
AATGTACCTGCTACCTTTATGCTTGTGTCTTTAGACGAAGGACCAGGTCCTCCAATCAAA
TATCAGTATGCTGAATTAGGCAAGTTATATTCAGTAGTGTCTCAGCTGATTCGTTGTTGC
AATGTGTCATCAACAATGCAGTCTTCAATCAATGGTAATCCCCCTCTCCCCAATCCTTTC
GGTGACCTTAATTTATCACAGCCTATAATGCCAATTCAGCAGAATGTGTTAGACATTTTA
TTTGTGAGAACAAGTTATGTGAAGAAAATTATTGAAGACTGCAGTAACTCAGAGGATACC
ATCAAATTACTTCGCTTTTGCTCTTGGGAGAATCCTCAGTTCTCATCTACTGTCCTCAGC
GAACTTCTCTGGCAGGTTGCATATTCATATACCTATGAACTTCGGCCATATTTAGATCTA
CTTTTCCAAATTTTACTGATTGAGGACTCCTGGCAGACTCACAGAATTCATAATGCACTT
AAAGGAATTCCAGATGACAGAGATGGGCTGTTCGATACAATACAGCGCTCGAAGAATCAC
TATCAAAAACGAGCATATCAGTGCATAAAATGTATGGTAGCTCTATTTAGCAGTTGTCCT
GTTGCTTACCAGATCTTACAGGGTAACGGAGATCTTAAAAGAAAATGGACCTGGGCAGTG
GAATGGCTAGGAGATGAACTTGAAAGAAGACCATATACTGGCAATCCTCAGTATAGTTAC
AACAATTGGTCTCCTCCAGTACAAAGCAATGAAACAGCAAATGGTTATTTCTTAGAAAGA
TCACATAGTGCTAGGATGACACTTGCAAAAGCTTGTGAACTCTGTCCAGAAGAGGAGCCA
GATGACCAGGATGCCCCAGATGAGCATGAGCCCTCTCCATCAGAAGATGCCCCATTATAT
CCTCATTCACCTGCCTCTCAGTATCAACAGAATAATCATGTACATGGACAGCCATATACA
GGACCAGCAGCACATCACTTGAACAACCCTCAGAAAACAGGCCAACGAACACAAGAAAAT
TATGAAGGCAATGAAGAAGTATCCTCACCTCAGATGAAGGATCAGTGA

Protein Properties

Number of Residues

2555

Molecular Weight

291074.2

Theoretical pI

5.68

Pfam Domain Function

UCH (PF00443 )

Signals

None

Transmembrane Regions

None

Protein Sequence

>Probable ubiquitin carboxyl-terminal hydrolase FAF-Y
MTAITHGSPVGGNDSQGQVLDGQSQHLFQQNQTSSPDSSNENSVATPPPEEQGQGDAPPQ
HEDEEPAFPHTELANLDDMINRPRWVVPVLPKGELEVLLEAAIDLSVKGLDVKSEACQRF
FRDGLTISFTKILMDEAVSGWKFEIHRCIINNTHRLVELCVAKLSQDWFPLLELLAMALN
PHCKFHIYNGTRPCELISSNAQLPEDELFARSSDPRSPKGWLVDLINKFGTLNGFQILHD
RFFNGSALNIQIIAALIKPFGQCYEFLSQHTLKKYFIPVIEIVPHLLENLTDEELKKEAK
NEAKNDALSMIIKSLKNLASRISGQDETIKNLEIFRLKMILRLLQISSFNGKMNALNEIN
KVISSVSYYTHRHSNPEEEEWLTAERMAEWIQQNNILSIVLQDSLHQPQYVEKLEKILRF
VIKEKALTLQDLDNIWAAQAGKHEAIVKNVHDLLAKLAWDFSPGQLDHLFDCFKASWTNA
SKKQREKLLELIRRLAEDDKDGVMAHKVLNLLWNLAQSDDVPVDIMDLALSAHIKILDYS
CSQDRDAQKIQWIDHFIEELRTNDKWVIPALKQIREICSLFGEASQNLSQTQRSPHIFYR
HDLINQLQQNHALVTLVAENLATYMNSIRLYAGDHEDYDPQTVRLGSRYSHVQEVQERLN
FLRFLLKDGQLWLCAPQAKQIWKCLAENAVYLCDREACFKWYSKLMGDEPDLDPDINKDF
FESNVLQLDPSLLTENGMKCFERFFKAVNCRERKLIAKRRSYMMDDLELIGLDYLWRVVI
QSSDEIANRAIDLLKEIYTNLGPRLKANQVVIHEDFIQSCFDRLKASYDTLCVFDGDKNS
INCARQEAIRMVRVLTVIKEYINECDSDYHKERMILPMSRAFRGKHLSLIVRFPNQGRQV
DELDIWSHTNDTIGSVRRCIVNRIKANVAHKKIELFVGGELIDSEDDRKLIGQLNLKDKS
LITAKLTQINFNMPSSPDSSSDSSTASPGNHRNHYNDGPNLEVESCLPGVIMSVHPRYIS
FLWQVADLGSNLNMPPLRDGARVLMKLMPPDRTAVEKLRAVCLDHAKLGEGKLSPPLDSL
FFGPSASQVLYLTEVVYALLMPAGVPLTDGSSDFQVHFLKSGGLPLVLSMLIRNNFLPNT
DMETRRGAYLNALKIAKLLLTAIGYGHVRAVAEACQPVVDGTDPITQINQVTHDQAVVLQ
SALQSIPNPSSECVLRNESILLAQEISNEASRYMPDICVIRAIQKIIWASACGALGLVFS
PNEEITKIYQMTTNGSNKLEVEDEQVCCEALEVMTLCFALLPTALDALSKEKAWQTFIID
LLLHCPSKTVRQLAQEQFFLMCTRCCMGHRPLLFFITLLFTILGSTAREKGKYSGDYFTL
LRHLLNYAYNGNINIPNAEVLLVSEIDWLKRIRDNVKNTGETGVEEPILEGHLGVTKELL
AFQTSEKKYHFGCEKGGANLIKELIDDFIFPASKVYLQYLRSGELPAEQAIPVCSSPVTI
NAGFELLVALAIGCVRNLKQIVDCLTEMYYMGTAITTCEALTEWEYLPPVGPRPPKGFVG
LKNAGATCYMNSVIQQLYMIPSIRNSILAIEGTGSDLHDDMFGDEKQDSESNVDPRDDVF
GYPHQFEDKPALSKTEDRKEYNIGVLRHLQVIFGHLAASQLQYYVPRGFWKQFRLWGEPV
NLREQHDALEFFNSLVDSLDEALKALGHPAILSKVLGGSFADQKICQGCPHRYECEESFT
TLNVDIRNHQNLLDSLEQYIKGDLLEGANAYHCEKCDKKVDTVKRLLIKKLPRVLAIQLK
RFDYDWERECAIKFNDYFEFPRELDMGPYTVAGVANLERDNVNSENELIEQKEQSDNETA
GGTKYRLVGVLVHSGQASGGHYYSYIIQRNGKDDQTDHWYKFDDGDVTECKMDDDEEMKN
QCFGGEYMGEVFDHMMKRMSYRRQKRWWNAYILFYEQMDMIDEDDEMIRYISELTIARPH
QIIMSPAIERSVRKQNVKFMHNRLQYSLEYFQFVKKLLTCNGVYLNPAPGQDYLLPEAEE
ITMISIQLAARFLFTTGFHTKKIVRGPASDWYDALCVLLRHSKNVRFWFTHNVLFNVSNR
FSEYLLECPSAEVRGAFAKLIVFIAHFSLQDGSCPSPFASPGPSSQACDNLSLSDHLLRA
TLNLLRREVSEHGHHLQQYFNLFVMYANLGVAEKTQLLKLNVPATFMLVSLDEGPGPPIK
YQYAELGKLYSVVSQLIRCCNVSSTMQSSINGNPPLPNPFGDLNLSQPIMPIQQNVLDIL
FVRTSYVKKIIEDCSNSEDTIKLLRFCSWENPQFSSTVLSELLWQVAYSYTYELRPYLDL
LFQILLIEDSWQTHRIHNALKGIPDDRDGLFDTIQRSKNHYQKRAYQCIKCMVALFSSCP
VAYQILQGNGDLKRKWTWAVEWLGDELERRPYTGNPQYSYNNWSPPVQSNETANGYFLER
SHSARMTLAKACELCPEEEPDDQDAPDEHEPSPSEDAPLYPHSPASQYQQNNHVHGQPYT
GPAAHHLNNPQKTGQRTQENYEGNEEVSSPQMKDQ

External Links

GenBank ID Protein

74319833

UniProtKB/Swiss-Prot ID

O00507

UniProtKB/Swiss-Prot Entry Name

USP9Y_HUMAN

PDB IDs

Not Available

GenBank Gene ID

GeneCard ID

GenAtlas ID

HGNC ID

References

General References

Lahn BT, Page DC: Functional coherence of the human Y chromosome. Science. 1997 Oct 24;278(5338):675-80. [PubMed:9381176 ]
Hillman RT, Green RE, Brenner SE: An unappreciated role for RNA surveillance. Genome Biol. 2004;5(2):R8. Epub 2004 Feb 2. [PubMed:14759258 ]
Skaletsky H, Kuroda-Kawaguchi T, Minx PJ, Cordum HS, Hillier L, Brown LG, Repping S, Pyntikova T, Ali J, Bieri T, Chinwalla A, Delehaunty A, Delehaunty K, Du H, Fewell G, Fulton L, Fulton R, Graves T, Hou SF, Latrielle P, Leonard S, Mardis E, Maupin R, McPherson J, Miner T, Nash W, Nguyen C, Ozersky P, Pepin K, Rock S, Rohlfing T, Scott K, Schultz B, Strong C, Tin-Wollam A, Yang SP, Waterston RH, Wilson RK, Rozen S, Page DC: The male-specific region of the human Y chromosome is a mosaic of discrete sequence classes. Nature. 2003 Jun 19;423(6942):825-37. [PubMed:12815422 ]
Jones MH, Furlong RA, Burkin H, Chalmers IJ, Brown GM, Khwaja O, Affara NA: The Drosophila developmental gene fat facets has a human homologue in Xp11.4 which escapes X-inactivation and has related sequences on Yq11.2. Hum Mol Genet. 1996 Nov;5(11):1695-701. [PubMed:8922996 ]
Brown GM, Furlong RA, Sargent CA, Erickson RP, Longepied G, Mitchell M, Jones MH, Hargreave TB, Cooke HJ, Affara NA: Characterisation of the coding sequence and fine mapping of the human DFFRY gene and comparative expression analysis and mapping to the Sxrb interval of the mouse Y chromosome of the Dffry gene. Hum Mol Genet. 1998 Jan;7(1):97-107. [PubMed:9384609 ]
Sun C, Skaletsky H, Birren B, Devon K, Tang Z, Silber S, Oates R, Page DC: An azoospermic man with a de novo point mutation in the Y-chromosomal gene USP9Y. Nat Genet. 1999 Dec;23(4):429-32. [PubMed:10581029 ]
Luddi A, Margollicci M, Gambera L, Serafini F, Cioni M, De Leo V, Balestri P, Piomboni P: Spermatogenesis in a man with complete deletion of USP9Y. N Engl J Med. 2009 Feb 26;360(9):881-5. doi: 10.1056/NEJMoa0806218. [PubMed:19246359 ]