| Identification |
|---|
| HMDB Protein ID
| HMDBP10133 |
| Secondary Accession Numbers
| |
| Name
| Ubiquitin carboxyl-terminal hydrolase |
| Synonyms
|
Not Available
|
| Gene Name
| USP14 |
| Protein Type
| Enzyme |
| Biological Properties |
|---|
| General Function
| Involved in ubiquitin thiolesterase activity |
| Specific Function
| Ubiquitin C-terminal thioester + H(2)O = ubiquitin + a thiol |
| Pathways
|
Not Available
|
| Reactions
| Not Available |
| GO Classification
|
| Function |
| hydrolase activity, acting on ester bonds |
| catalytic activity |
| hydrolase activity |
| ubiquitin thiolesterase activity |
| thiolester hydrolase activity |
| Process |
| metabolic process |
| catabolic process |
| macromolecule catabolic process |
| cellular macromolecule catabolic process |
| modification-dependent macromolecule catabolic process |
| modification-dependent protein catabolic process |
| ubiquitin-dependent protein catabolic process |
|
| Cellular Location
|
- Cytoplasmic
|
| Gene Properties |
|---|
| Chromosome Location
| Chromosome:1 |
| Locus
| 18p11.32 |
| SNPs
| USP14 |
| Gene Sequence
|
>1380 bp
ATGCCGCTCTACTCCGTTACTGTAAAATGGGGAAAGGAGAAATTTGAAGGTGTAGAATTG
AATACAGATGAACCTCCAATGGTATTCAAGGCTCAGCTGTTTGCGTTGACTGGAGTCCAG
CCTGCCAGACAGAAAGTTATGGTGAAAGGAGGAACGCTAAAGGATGATGATTGGGGAAAC
ATCAAAATAAAAAATATGGAGTTACCATGTGGATTGACAAACCTTGGTAACACTTGTTAC
ATGAATGCCACAGTTCAGTGTATTCGTTCTGTGCCTGAACTCAAAGATGCCCTTAAAAGG
TATGCAGGTGCCTTGAGAGCTTCAGGGGAAATGGCTTCAGCGCAGTATATTACTGCAGCC
CTTAGAGATTTGTTTGATTCCATGGATAAAACTTCTTCCAGTATTCCACCTATTATTCTA
CTGCAGTTTTTGCACATGGCTTTCCCACAGTTTGCCGAGAAAGGTGAACAAGGACAGTAT
CTTCAACAGGATGCTAATGAATGTTGGATACAAATGATGCGAGTATTGCAACAGAAATTG
GAAGCAATAGAGGATGATTCTGTTAAAGAGACAGACTCCTCATCTGCATCGGCAGCGACA
CCTTCTAAAAAGAAAAGTTTAATCGATCAGTTCTTCGGTGTTGAGTTTGAAACTACCATG
AAATGTACAGAATCTGAAGAAGAAGAAGTCACCAAAGGAAAGGAAAATCAACTTCAGCTT
AGCTGTTTTATCAATCAGGAAGTCAAGTATCTTTTTACAGGACTTAAATTGCGACTTCAG
GAAGAAATCACCAAACAGTCTCCAACGTTGCAAAGAAATGCCTTGTATATCAAATCTTCC
AAGATCAGCCGGCTGCCTGCTTACTTGACCATTCAGATGGTTCGATTTTTTTATAAAGAG
AAGGAATCTGTGAATGCCAAAGTTCTTAAGGATGTTAAATTTCCTCTTATGTTGGATATG
TATGAACTGTGTACACCAGAACTTCAAGAGAAAATGGTGTCTTTTCGATCCAAATTCAAG
GATCTAGAAGATAAAAAAGTGAATCAGCAGCCAAATACAAGTGACAAAAAGAGTAGTCCC
CAGAAAGAAGTTAAGTATGAACCCTTTTCTTTTGCTGATGATATTGGCTCCAATAATTGT
GGATACTATGACTTACAAGCAGTACTAACACACCAGGGAAGGTCTAGTTCTTCAGGTCAT
TATGTATCATGGGTGAAAAGGAAACAAGATGAATGGATTAAGTTTGATGATGACAAAGTC
AGCATCGTAACACCAGAAGATATCTTACGGCTTTCTGGTGGTGGAGACTGGCATATCGCT
TACGTTCTACTCTATGGGCCTCGCAGAGTTGAAATAATGGAAGAGGAAAGTGAACAGTAA
|
| Protein Properties |
|---|
| Number of Residues
| 459 |
| Molecular Weight
| 52385.5 |
| Theoretical pI
| 5.46 |
| Pfam Domain Function
|
|
| Signals
|
|
|
Transmembrane Regions
|
|
| Protein Sequence
|
>Ubiquitin carboxyl-terminal hydrolase
MPLYSVTVKWGKEKFEGVELNTDEPPMVFKAQLFALTGVQPARQKVMVKGGTLKDDDWGN
IKIKNMELPCGLTNLGNTCYMNATVQCIRSVPELKDALKRYAGALRASGEMASAQYITAA
LRDLFDSMDKTSSSIPPIILLQFLHMAFPQFAEKGEQGQYLQQDANECWIQMMRVLQQKL
EAIEDDSVKETDSSSASAATPSKKKSLIDQFFGVEFETTMKCTESEEEEVTKGKENQLQL
SCFINQEVKYLFTGLKLRLQEEITKQSPTLQRNALYIKSSKISRLPAYLTIQMVRFFYKE
KESVNAKVLKDVKFPLMLDMYELCTPELQEKMVSFRSKFKDLEDKKVNQQPNTSDKKSSP
QKEVKYEPFSFADDIGSNNCGYYDLQAVLTHQGRSSSSGHYVSWVKRKQDEWIKFDDDKV
SIVTPEDILRLSGGGDWHIAYVLLYGPRRVEIMEEESEQ
|
| External Links |
|---|
| GenBank ID Protein
| 82880645 |
| UniProtKB/Swiss-Prot ID
| A6NJA2 |
| UniProtKB/Swiss-Prot Entry Name
| A6NJA2_HUMAN |
| PDB IDs
|
Not Available |
| GenBank Gene ID
| NM_001037334.1 |
| GeneCard ID
| USP14 |
| GenAtlas ID
| USP14 |
| HGNC ID
| HGNC:12612 |
| References |
|---|
| General References
| - Nusbaum C, Zody MC, Borowsky ML, Kamal M, Kodira CD, Taylor TD, Whittaker CA, Chang JL, Cuomo CA, Dewar K, FitzGerald MG, Yang X, Abouelleil A, Allen NR, Anderson S, Bloom T, Bugalter B, Butler J, Cook A, DeCaprio D, Engels R, Garber M, Gnirke A, Hafez N, Hall JL, Norman CH, Itoh T, Jaffe DB, Kuroki Y, Lehoczky J, Lui A, Macdonald P, Mauceli E, Mikkelsen TS, Naylor JW, Nicol R, Nguyen C, Noguchi H, O'Leary SB, O'Neill K, Piqani B, Smith CL, Talamas JA, Topham K, Totoki Y, Toyoda A, Wain HM, Young SK, Zeng Q, Zimmer AR, Fujiyama A, Hattori M, Birren BW, Sakaki Y, Lander ES: DNA sequence and analysis of human chromosome 18. Nature. 2005 Sep 22;437(7058):551-5. [PubMed:16177791 ]
|
