Hmdb loader
Identification
HMDB Protein ID HMDBP10629
Secondary Accession Numbers
  • 16858
Name Poly(ADP-ribose) glycohydrolase
Synonyms Not Available
Gene Name PARG
Protein Type Enzyme
Biological Properties
General Function Involved in poly(ADP-ribose) glycohydrolase activity
Specific Function Poly(ADP-ribose) synthesized after DNA damage is only present transiently and is rapidly degraded by poly(ADP-ribose) glycohydrolase. Poly(ADP-ribose) metabolism may be required for maintenance of the normal function of neuronal cells
Pathways Not Available
Reactions Not Available
GO Classification
Function
catalytic activity
hydrolase activity
hydrolase activity, acting on glycosyl bonds
hydrolase activity, hydrolyzing o-glycosyl compounds
poly(adp-ribose) glycohydrolase activity
Process
metabolic process
primary metabolic process
carbohydrate metabolic process
Cellular Location
  1. Isoform 3:Cytoplasm
Gene Properties
Chromosome Location Chromosome:1
Locus 10q11.23
SNPs PARG
Gene Sequence
>2931 bp
ATGAATGCGGGCCCCGGCTGTGAACCCTGCACCAAAGCGACCCGCTGGGGCGCCGCTACA
ACTTCGCCGGCTGCTTCGGACGCCCGGAGCTTTCCGAGCAGGCAGAGGCGCGTCCTCGAC
CCCAAGGACGCTCACGTGCAGTTCAGGGTCCCACCGTCCTCGCCAGCCTGCGTCCCAGGG
CAGGCGGGACAGCACAGAGGCAGCGCCACCTCGCTTGTTTTCAAACAAAAGACTATTACC
AGTTGGATGGACACTAAAGGAATCAAGACAGCGGAATCAGAAAGTTTGGATAGTAAAGAA
AACAACAATACAAGAATAGAATCCATGATGAGTTCTGTACAAAAAGATAACTTTTACCAA
CATAATGTAGAAAAATTAGTAAATGTTTCTCAGCTAAGTCTTGATAAGTCACTCACTGAA
AAAAGTACACAGTATTTGAACCAGCATCAGACTGCAGCAATGTGTAAGTGGCAAAATGAA
GGGAAACACACGGAGCAGCTTTTGGAAAGTGAACCTCAAACAGTAACCCTGGTACCAGAG
CAGTTTAGTAATGCTAACATTGATCGGTCACCTCAAAATGATGATCACAGTGACACAGAT
AGTGAAGAGAATAGAGACAATCAACAGTTTCTCACAACTGTAAAGCTTGCAAATGCAAAG
CAGACTACGGAAGATGAACACGCCAGAGAAGCCAAAAGCCACCAGAAGTGCAGCAAGTCT
TGCCATCCTGGGGAAGACTGTGCAAGTTGTCAGCAAGATGAGATAGACGTGGTGCCAAAG
AGTCCATTGTCAGATGTTGGCTCTGAGGATGTTGGTACTGGGTCAAAAAATGACAACAAA
TTGATTAGACAAGAAAGTTGCCTAGGAAATTCTCCTCCATTTGAGAAGGAAAGTGAACCC
GAATCACCGATGGATGTGGATAATTCTAAAAATAGTTGTCAAGACTCAGAAGCAGATGAG
GAGACAAGTCCAGGTTTTGATGAACAAGAAGATGGTAGTTCCTCCCAAACAGCAAATAAA
CCTTCAAGGTTCCAAGCAAGAGACGCTGACATTGAATTTAGGAAACGGTACTCTACTAAG
GGCGGTGAAGTTAGATTACATTTCCAATTTGAAGGAGGAGAGAGTCGCACTGGAATGAAT
GATTTAAATGCTAAACTACCTGGAAATATTTCTAGCCTGAATGTAGAATGCAGAAATTCT
AAGCAACATGGAAAAAAGGATTCTAAAATCACAGATCATTTGATGAGACTGCCCAAAGCA
GAGGACAGAAGAAAAGAACAGTGGGAAACCAAACATCAAAGAACAGAAAGGAAGATCCCT
AAATACGTTCCACCTCACCTTTCTCCAGATAAGAAGTGGCTTGGAACTCCCATTGAGGAG
ATGAGAAGAATGCCTCGGTGTGGGATCCGGCTGCCTCTCTTGAGACCATCTGCCAATCAC
ACAGTAACTATTCGGGTAGATCTTTTGCGAGCAGGAGAAGTTCCTAAACCTTTTCCAACA
CATTATAAAGATTTGTGGGATAACAAGCATGTTAAAATGCCTTGTTCAGAACAAAATTTG
TACCCAGTGGAAGATGAGAATGGTGAGCGAACTGCGGGGAGCCGGTGGGAGCTCATTCAG
ACTGCACTTCTCAACAAATTTACACGACCCCAAAACTTGAAGGATGCTATTCTGAAATAC
AATGTGGCATATTCTAAGAAATGGGACTTTACAGCTTTGATCGATTTCTGGGATAAGGTA
CTTGAAGAAGCAGAAGCTCAACATTTATATCAGTCCATCTTGCCTGATATGGTGAAAATT
GCACTCTGTCTGCCAAATATTTGCACCCAGCCAATACCACTCCTGAAACAGAAGATGAAT
CATTCCATCACAATGTCGCAGGAACAGATTGCCAGTCTTTTAGCTAATGCTTTCTTCTGC
ACATTTCCACGACGAAATGCTAAGATGAAATCGGAGTATTCTAGTTACCCAGACATTAAC
TTCAATCGATTGTTTGAGGGACGTTCATCAAGGAAACCGGAGAAACTTAAAACGCTCTTC
TGCTACTTTAGAAGAGTCACAGAGAAAAAACCTACTGGGTTGGTGACATTTACAAGACAG
AGTCTTGAAGATTTTCCAGAATGGGAAAGATGTGAAAAACCCTTGACACGATTGCATGTC
ACTTACGAAGGTACCATAGAAGAAAATGGCCAAGGCATGCTACAGGTGGATTTTGCAAAT
CGTTTTGTTGGAGGTGGTGTAACCAGTGCAGGACTTGTGCAAGAAGAAATCCGCTTTTTA
ATCAATCCTGAGTTGATTATTTCACGGCTCTTCACTGAGGTGCTGGATCACAATGAATGT
CTAATTATCACAGGTACTGAGCAGTACAGTGAATACACAGGCTATGCTGAGACATATCGT
TGGTCCCGGAGCCACGAAGATGGGAGTGAAAGGGACGACTGCGAGCGGCGCTGCACTGAG
ATCGTTGCCATCGATGCTCTTCACTTCAGACGCTACCTCGATCAGTTTGTGCCTGAGAAA
ATGAGACGCGAGCTGAACAAGGCTTACTGTGGATTTCTCCGTCCTGGAGTTTCTTCAGAG
AATCTTTCTGCAGTGGCCACAGGAAACTGGGGCTGTGGTGCCTTTGGGGGTGATGCCAGG
TTAAAAGCCTTAATACAGATATTGGCAGCTGCTGCAGCTGAGCGAGATGTGGTTTATTTC
ACCTTTGGGGACTCAGAATTGATGAGAGACATTTACAGCATGCACATTTTCCTTACTGAA
AGGAAACTCACTGTTGGAGATGTGTATAAGCTGTTGCTACGATACTACAATGAAGAATGC
AGAAACTGTTCCACCCCTGGACCAGACATCAAGCTTTATCCATTCATATACCATGCTGTC
GAGTCCTGTGCAGAGACCGCTGACCATTCAGGGCAAAGGACAGGGACCTGA
Protein Properties
Number of Residues 976
Molecular Weight 111109.5
Theoretical pI 6.39
Pfam Domain Function
Signals
  • None
Transmembrane Regions
  • None
Protein Sequence
>Poly(ADP-ribose) glycohydrolase
MNAGPGCEPCTKRPRWGAATTSPAASDARSFPSRQRRVLDPKDAHVQFRVPPSSPACVPG
RAGQHRGSATSLVFKQKTITSWMDTKGIKTAESESLDSKENNNTRIESMMSSVQKDNFYQ
HNVEKLENVSQLSLDKSPTEKSTQYLNQHQTAAMCKWQNEGKHTEQLLESEPQTVTLVPE
QFSNANIDRSPQNDDHSDTDSEENRDNQQFLTTVKLANAKQTTEDEQAREAKSHQKCSKS
CDPGEDCASCQQDEIDVVPESPLSDVGSEDVGTGPKNDNKLTRQESCLGNSPPFEKESEP
ESPMDVDNSKNSCQDSEADEETSPGFDEQEDGSSSQTANKPSRFQARDADIEFRKRYSTK
GGEVRLHFQFEGGESRTGMNDLNAKLPGNISSLNVECRNSKQHGKKDSKITDHFMRLPKA
EDRRKEQWETKHQRTERKIPKYVPPHLSPDKKWLGTPIEEMRRMPRCGIRLPLLRPSANH
TVTIRVDLLRAGEVPKPFPTHYKDLWDNKHVKMPCSEQNLYPVEDENGERTAGSRWELIQ
TALLNKFTRPQNLKDAILKYNVAYSKKWDFTALIDFWDKVLEEAEAQHLYQSILPDMVKI
ALCLPNICTQPIPLLKQKMNHSITMSQEQIASLLANAFFCTFPRRNAKMKSEYSSYPDIN
FNRLFEGRSSRKPEKLKTLFCYFRRVTEKKPTGLVTFTRQSLEDFPEWERCEKPLTRLHV
TYEGTIEENGQGMLQVDFANRFVGGGVTSAGLVQEEIRFLINPELIISRLFTEVLDHNEC
LIITGTEQYSEYTGYAETYRWSRSHEDGSERDDWQRRCTEIVAIDALHFRRYLDQFVPEK
MRRELNKAYCGFLRPGVSSENLSAVATGNWGCGAFGGDARLKALIQILAAAAAERDVVYF
TFGDSELMRDIYSMHIFLTERKLTVGDVYKLLLRYYNEECRNCSTPGPDIKLYPFIYHAV
ESCAETADHSGQRTGT
GenBank ID Protein 2213922
UniProtKB/Swiss-Prot ID Q86W56
UniProtKB/Swiss-Prot Entry Name PARG_HUMAN
PDB IDs Not Available
GenBank Gene ID AF005043
GeneCard ID PARG
GenAtlas ID PARG
HGNC ID HGNC:8605
References
General References
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  3. Choudhary C, Kumar C, Gnad F, Nielsen ML, Rehman M, Walther TC, Olsen JV, Mann M: Lysine acetylation targets protein complexes and co-regulates major cellular functions. Science. 2009 Aug 14;325(5942):834-40. doi: 10.1126/science.1175371. Epub 2009 Jul 16. [PubMed:19608861 ]
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