Showing Protein Alpha-(1,3)-fucosyltransferase (HMDBP10701)

• 16962

1. Fuc-TVII
2. FucT-VII
3. Fucosyltransferase 7
4. Fucosyltransferase VII
5. Galactoside 3-L-fucosyltransferase
6. Selectin ligand synthase

• Glycosphingolipid biosynthesis - lacto and neolacto series
• Other types of O-glycan biosynthesis
• protein glycosylation

1. Single-pass type II membrane protein
2. Golgi apparatus
3. Golgi stack membrane

>1029 bp
ATGAATAATGCTGGGCACGGCCCCACCCGGAGGCTGCGAGGCTTGGGGGTCCTGGCCGGG
GTGGCTCTGCTCGCTGCCCTCTGGCTCCTGTGGCTGCTGGGGTCAGCCCCTCGGGGTACC
CCGGCACCCCAGCCCACGATCACCATCCTTGTCTGGCACTGGCCCTTCACTGACCAGCCC
CCAGAGCTGCCCAGCGACACCTGCACCCGCTACGGCATCGCCCGCTGCCACCTGAGTGCC
AACCGAAGCCTGCTGGCCAGCGCCGACGCCGTGGTCTTCCACCACCGCGAGCTGCAGACC
CGGCGGTCCCACCTGCCCCTGGCCCAGCGGCCGCGAGGGCAGCCCTGGGTGTGGGCCTCC
ATGGAGTCTCCTAGCCACACCCACGGCCTCAGCCACCTCCGAGGCATCTTCAACTGGGTG
CTGAGCTACCGGCGCGACTCGGACATCTTTGTGCCCTATGGCCGCCTGGAGCCCCACTGG
GGGCCCTCGCCACCGCTGCCAGCCAAGAGCAGGGTGGCCGCCTGGGTGGTCAGCAACTTC
CAGGAGCGGCAGCTGCGTGCCAGGCTGTACCGGCAGCTGGCGCCTCATCTGCGGGTGGAT
GTCTTTGGCCGTGCCAATGGACGGCCACTGTGCGCCAGCTGCCTGGTGCCCACCGTGGCC
CAGTACCGCTTCTACCTGTCCTTTGAGAACTCTCAGCACCGCGACTACATTACGGAGAAA
TTCTGGCGCAACGCACTGGTGGCTGGCACTGTGCCAGTGGTGCTGGGGCCCCCACGGGCC
ACCTATGAGGCCTTCGTGCCGGCTGACGCCTTCGTGCATGTGGATGACTTTGGCTCAGCC
CGAGAGCTGGCGGCTTTCCTCACTGGCATGAATGAGAGCCGATACCAACGCTTCTTTGCC
TGGCGTGACAGGCTCCGCGTGCGACTGTTCACCGACTGGCGGGAACGTTTCTGTGCCATC
TGTGACCGCTACCCACACCTACCCCGCAGCCAAGTCTATGAGGACCTTGAGGGTTGGTTT
CAGGCCTGA

• Glyco_transf_10 (PF00852 )

>Alpha-(1,3)-fucosyltransferase
MNNAGHGPTRRLRGLGVLAGVALLAALWLLWLLGSAPRGTPAPQPTITILVWHWPFTDQP
PELPSDTCTRYGIARCHLSANRSLLASADAVVFHHRELQTRRSHLPLAQRPRGQPWVWAS
MESPSHTHGLSHLRGIFNWVLSYRRDSDIFVPYGRLEPHWGPSPPLPAKSRVAAWVVSNF
QERQLRARLYRQLAPHLRVDVFGRANGRPLCASCLVPTVAQYRFYLSFENSQHRDYITEK
FWRNALVAGTVPVVLGPPRATYEAFVPADAFVHVDDFGSARELAAFLTGMNESRYQRFFA
WRDRLRVRLFTDWRERFCAICDRYPHLPRSQVYEDLEGWFQA

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4. Natsuka S, Gersten KM, Zenita K, Kannagi R, Lowe JB: Molecular cloning of a cDNA encoding a novel human leukocyte alpha-1,3-fucosyltransferase capable of synthesizing the sialyl Lewis x determinant. J Biol Chem. 1994 Jun 17;269(24):16789-94. [PubMed:8207002 ]
5. Natsuka S, Gersten KM, Zenita K, Kannagi R, Lowe JB: Molecular cloning of a cDNA encoding a novel human leukocyte alpha-1,3-fucosyltransferase capable of synthesizing the sialyl Lewis x determinant. J Biol Chem. 1994 Aug 12;269(32):20806. [PubMed:8051184 ]
6. Sasaki K, Kurata K, Funayama K, Nagata M, Watanabe E, Ohta S, Hanai N, Nishi T: Expression cloning of a novel alpha 1,3-fucosyltransferase that is involved in biosynthesis of the sialyl Lewis x carbohydrate determinants in leukocytes. J Biol Chem. 1994 May 20;269(20):14730-7. [PubMed:8182079 ]
7. de Vries T, Yen TY, Joshi RK, Storm J, van Den Eijnden DH, Knegtel RM, Bunschoten H, Joziasse DH, Macher BA: Neighboring cysteine residues in human fucosyltransferase VII are engaged in disulfide bridges, forming small loop structures. Glycobiology. 2001 May;11(5):423-32. [PubMed:11425803 ]