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Identification
HMDB Protein ID HMDBP10732
Secondary Accession Numbers
  • 16994
Name Fibroblast growth factor-binding protein 1
Synonyms
  1. 17 kDa HBGF-binding protein
  2. 17 kDa heparin-binding growth factor-binding protein
  3. FGF-BP
  4. FGF-BP1
  5. FGF-binding protein 1
  6. FGFBP-1
  7. HBp17
Gene Name FGFBP1
Protein Type Unknown
Biological Properties
General Function Involved in heparin binding
Specific Function Acts as a carrier protein that release fibroblast- binding factors (FGFs) from the extracellular matrix (EM) storage and thus enhance the mitogenic activity of FGFs. Enhances FGF2 signaling during tissue repair, angiogenesis and in tumor growth
Pathways Not Available
Reactions Not Available
GO Classification Not Available
Cellular Location
  1. Cell membrane
  2. Peripheral membrane protein
  3. Secreted
  4. extracellular space
Gene Properties
Chromosome Location Chromosome:4
Locus 4p15.32
SNPs FGFBP1
Gene Sequence
>705 bp
ATGAAGATCTGTAGCCTCACCCTGCTCTCCTTCCTCCTACTGGCTGCTCAGGTGCTCCTG
GTGGAGGGGAAAAAAAAAGTGAAGAATGGACTTCACAGCAAAGTGGTCTCAGAACAAAAG
GACACTCTGGGCAACACCCAGATTAAGCAGAAAAGCAGGCCCGGGAACAAAGGCAAGTTT
GTCACCAAAGACCAAGCCAACTGCAGATGGGCTGCTACTGAGCAGGAGGAGGGCATCTCT
CTCAAGGTTGAGTGCACTCAATTGGACCATGAATTTTCCTGTGTCTTTGCTGGCAATCCA
ACCTCATGCCTAAAGCTCAAGGATGAGAGAGTCTATTGGAAACAAGTTGCCCGGAATCTG
CGCTCACAGAAAGACATCTGTAGATATTCCAAGACAGCTGTGAAAACCAGAGTGTGCAGA
AAGGATTTTCCAGAATCCAGTCTTAAGCTAGTCAGCTCCACTCTATTTGGGAACACAAAG
CCCAGGAAGGAGAAAACAGAGATGTCCCCCAGGGAGCACATCAAGGGCAAAGAGACCACC
CCCTCTAGCCTAGCAGTGACCCAGACCATGGCCACCAAAGCTCCCGAGTGTGTGGAGGAC
CCAGATATGGCAAACCAGAGGAAGACTGCCCTGGAGTTCTGTGGAGAGACTTGGAGCTCT
CTCTGCACATTCTTCCTCAGCATAGTGCAGGACACGTCATGCTAA
Protein Properties
Number of Residues 234
Molecular Weight 26264.1
Theoretical pI 9.56
Pfam Domain Function
Signals
  • 1-23
Transmembrane Regions
  • None
Protein Sequence
>Fibroblast growth factor-binding protein 1
MKICSLTLLSFLLLAAQVLLVEGKKKVKNGLHSKVVSEQKDTLGNTQIKQKSRPGNKGKF
VTKDQANCRWAATEQEEGISLKVECTQLDHEFSCVFAGNPTSCLKLKDERVYWKQVARNL
RSQKDICRYSKTAVKTRVCRKDFPESSLKLVSSTLFGNTKPRKEKTEMSPREHIKGKETT
PSSLAVTQTMATKAPECVEDPDMANQRKTALEFCGETWSSLCTFFLSIVQDTSC
GenBank ID Protein 5070624
UniProtKB/Swiss-Prot ID Q14512
UniProtKB/Swiss-Prot Entry Name FGFP1_HUMAN
PDB IDs Not Available
GenBank Gene ID AF149412
GeneCard ID FGFBP1
GenAtlas ID FGFBP1
HGNC ID HGNC:19695
References
General References
  1. Ota T, Suzuki Y, Nishikawa T, Otsuki T, Sugiyama T, Irie R, Wakamatsu A, Hayashi K, Sato H, Nagai K, Kimura K, Makita H, Sekine M, Obayashi M, Nishi T, Shibahara T, Tanaka T, Ishii S, Yamamoto J, Saito K, Kawai Y, Isono Y, Nakamura Y, Nagahari K, Murakami K, Yasuda T, Iwayanagi T, Wagatsuma M, Shiratori A, Sudo H, Hosoiri T, Kaku Y, Kodaira H, Kondo H, Sugawara M, Takahashi M, Kanda K, Yokoi T, Furuya T, Kikkawa E, Omura Y, Abe K, Kamihara K, Katsuta N, Sato K, Tanikawa M, Yamazaki M, Ninomiya K, Ishibashi T, Yamashita H, Murakawa K, Fujimori K, Tanai H, Kimata M, Watanabe M, Hiraoka S, Chiba Y, Ishida S, Ono Y, Takiguchi S, Watanabe S, Yosida M, Hotuta T, Kusano J, Kanehori K, Takahashi-Fujii A, Hara H, Tanase TO, Nomura Y, Togiya S, Komai F, Hara R, Takeuchi K, Arita M, Imose N, Musashino K, Yuuki H, Oshima A, Sasaki N, Aotsuka S, Yoshikawa Y, Matsunawa H, Ichihara T, Shiohata N, Sano S, Moriya S, Momiyama H, Satoh N, Takami S, Terashima Y, Suzuki O, Nakagawa S, Senoh A, Mizoguchi H, Goto Y, Shimizu F, Wakebe H, Hishigaki H, Watanabe T, Sugiyama A, Takemoto M, Kawakami B, Yamazaki M, Watanabe K, Kumagai A, Itakura S, Fukuzumi Y, Fujimori Y, Komiyama M, Tashiro H, Tanigami A, Fujiwara T, Ono T, Yamada K, Fujii Y, Ozaki K, Hirao M, Ohmori Y, Kawabata A, Hikiji T, Kobatake N, Inagaki H, Ikema Y, Okamoto S, Okitani R, Kawakami T, Noguchi S, Itoh T, Shigeta K, Senba T, Matsumura K, Nakajima Y, Mizuno T, Morinaga M, Sasaki M, Togashi T, Oyama M, Hata H, Watanabe M, Komatsu T, Mizushima-Sugano J, Satoh T, Shirai Y, Takahashi Y, Nakagawa K, Okumura K, Nagase T, Nomura N, Kikuchi H, Masuho Y, Yamashita R, Nakai K, Yada T, Nakamura Y, Ohara O, Isogai T, Sugano S: Complete sequencing and characterization of 21,243 full-length human cDNAs. Nat Genet. 2004 Jan;36(1):40-5. Epub 2003 Dec 21. [PubMed:14702039 ]
  2. Gerhard DS, Wagner L, Feingold EA, Shenmen CM, Grouse LH, Schuler G, Klein SL, Old S, Rasooly R, Good P, Guyer M, Peck AM, Derge JG, Lipman D, Collins FS, Jang W, Sherry S, Feolo M, Misquitta L, Lee E, Rotmistrovsky K, Greenhut SF, Schaefer CF, Buetow K, Bonner TI, Haussler D, Kent J, Kiekhaus M, Furey T, Brent M, Prange C, Schreiber K, Shapiro N, Bhat NK, Hopkins RF, Hsie F, Driscoll T, Soares MB, Casavant TL, Scheetz TE, Brown-stein MJ, Usdin TB, Toshiyuki S, Carninci P, Piao Y, Dudekula DB, Ko MS, Kawakami K, Suzuki Y, Sugano S, Gruber CE, Smith MR, Simmons B, Moore T, Waterman R, Johnson SL, Ruan Y, Wei CL, Mathavan S, Gunaratne PH, Wu J, Garcia AM, Hulyk SW, Fuh E, Yuan Y, Sneed A, Kowis C, Hodgson A, Muzny DM, McPherson J, Gibbs RA, Fahey J, Helton E, Ketteman M, Madan A, Rodrigues S, Sanchez A, Whiting M, Madari A, Young AC, Wetherby KD, Granite SJ, Kwong PN, Brinkley CP, Pearson RL, Bouffard GG, Blakesly RW, Green ED, Dickson MC, Rodriguez AC, Grimwood J, Schmutz J, Myers RM, Butterfield YS, Griffith M, Griffith OL, Krzywinski MI, Liao N, Morin R, Palmquist D, Petrescu AS, Skalska U, Smailus DE, Stott JM, Schnerch A, Schein JE, Jones SJ, Holt RA, Baross A, Marra MA, Clifton S, Makowski KA, Bosak S, Malek J: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). Genome Res. 2004 Oct;14(10B):2121-7. [PubMed:15489334 ]
  3. Mongiat M, Otto J, Oldershaw R, Ferrer F, Sato JD, Iozzo RV: Fibroblast growth factor-binding protein is a novel partner for perlecan protein core. J Biol Chem. 2001 Mar 30;276(13):10263-71. Epub 2001 Jan 8. [PubMed:11148217 ]
  4. Wu DQ, Kan MK, Sato GH, Okamoto T, Sato JD: Characterization and molecular cloning of a putative binding protein for heparin-binding growth factors. J Biol Chem. 1991 Sep 5;266(25):16778-85. [PubMed:1885605 ]
  5. Tassi E, Al-Attar A, Aigner A, Swift MR, McDonnell K, Karavanov A, Wellstein A: Enhancement of fibroblast growth factor (FGF) activity by an FGF-binding protein. J Biol Chem. 2001 Oct 26;276(43):40247-53. Epub 2001 Aug 16. [PubMed:11509569 ]
  6. Xie B, Tassi E, Swift MR, McDonnell K, Bowden ET, Wang S, Ueda Y, Tomita Y, Riegel AT, Wellstein A: Identification of the fibroblast growth factor (FGF)-interacting domain in a secreted FGF-binding protein by phage display. J Biol Chem. 2006 Jan 13;281(2):1137-44. Epub 2005 Oct 27. [PubMed:16257968 ]
  7. Beer HD, Bittner M, Niklaus G, Munding C, Max N, Goppelt A, Werner S: The fibroblast growth factor binding protein is a novel interaction partner of FGF-7, FGF-10 and FGF-22 and regulates FGF activity: implications for epithelial repair. Oncogene. 2005 Aug 11;24(34):5269-77. [PubMed:15806171 ]
  8. Czubayko F, Liaudet-Coopman ED, Aigner A, Tuveson AT, Berchem GJ, Wellstein A: A secreted FGF-binding protein can serve as the angiogenic switch in human cancer. Nat Med. 1997 Oct;3(10):1137-40. [PubMed:9334727 ]