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Identification
HMDB Protein ID HMDBP10739
Secondary Accession Numbers
  • 17001
Name Paired mesoderm homeobox protein 1
Synonyms
  1. Homeobox protein PHOX1
  2. PRX-1
  3. Paired-related homeobox protein 1
Gene Name PRRX1
Protein Type Unknown
Biological Properties
General Function Involved in DNA binding
Specific Function Acts as a transcriptional regulator of muscle creatine kinase (MCK) and so has a role in the establishment of diverse mesodermal muscle types. The protein binds to an A/T-rich element in the muscle creatine enhancer
Pathways Not Available
Reactions Not Available
GO Classification
Component
organelle
membrane-bounded organelle
intracellular membrane-bounded organelle
nucleus
Function
binding
transcription regulator activity
nucleic acid binding
dna binding
sequence-specific dna binding
sequence-specific dna binding transcription factor activity
Process
multicellular organismal process
multicellular organismal development
biological regulation
regulation of biological process
regulation of metabolic process
regulation of macromolecule metabolic process
regulation of gene expression
regulation of transcription
regulation of transcription, dna-dependent
Cellular Location
  1. Nucleus
Gene Properties
Chromosome Location Chromosome:1
Locus 1q24
SNPs PRRX1
Gene Sequence
>735 bp
ATGACCTCCAGCTACGGGCACGTTCTGGAGCGGCAACCGGCGCTGGGCGGCCGCTTGGAC
AGCCCGGGCAACCTCGACACCCTGCAGGCGAAAAAGAACTTCTCCGTCAGTCACCTGCTA
GACCTGGAGGAAGCCGGGGACATGGTGGCGGCACAGGCGGATGAGAACGTGGGCGAGGCT
GGCCGGAGCCTGCTGGAGTCGCCGGGACTCACCAGCGGCAGCGACACCCCGCAGCAGGAC
AATGACCAGCTGAACTCAGAAGAAAAAAAGAAGAGAAAGCAGCGAAGGAATAGGACAACC
TTCAATAGCAGCCAGCTGCAGGCTTTGGAGCGTGTCTTTGAGCGGACACACTATCCTGAT
GCTTTTGTGCGAGAAGACCTTGCCCGCCGGGTGAACCTCACCGAGGCGAGAGTGCAGGTG
TGGTTTCAGAACCGAAGAGCCAAGTTCCGCAGGAATGAGAGAGCCATGCTAGCCAATAAA
AACGCTTCCCTCCTCAAATCCTACTCAGGAGACGTGACTGCTGTGGAGCAGCCCATCGTA
CCTCGTCCTGCTCCGAGACCCACCGATTATCTCTCCTGGGGGACAGCGTCTCCGTACAGC
GCCATGGCTACTTATTCTGCCACATGTGCCAACAATAGCCCTGCACAGGGCATCAACATG
GCCAACAGCATTGCCAACCTGAGACTGAAGGCCAAGGAATATAGTTTACAGAGGAACCAG
GTGCCAACAGTCAAC
Protein Properties
Number of Residues 245
Molecular Weight 27296.2
Theoretical pI 9.91
Pfam Domain Function
Signals
  • None
Transmembrane Regions
  • None
Protein Sequence
>Paired mesoderm homeobox protein 1
MTSSYGHVLERQPALGGRLDSPGNLDTLQAKKNFSVSHLLDLEEAGDMVAAQADENVGEA
GRSLLESPGLTSGSDTPQQDNDQLNSEEKKKRKQRRNRTTFNSSQLQALERVFERTHYPD
AFVREDLARRVNLTEARVQVWFQNRRAKFRRNERAMLANKNASLLKSYSGDVTAVEQPIV
PRPAPRPTDYLSWGTASPYSAMATYSATCANNSPAQGINMANSIANLRLKAKEYSLQRNQ
VPTVN
GenBank ID Protein 197692627
UniProtKB/Swiss-Prot ID P54821
UniProtKB/Swiss-Prot Entry Name PRRX1_HUMAN
PDB IDs Not Available
GenBank Gene ID AB451463
GeneCard ID PRRX1
GenAtlas ID PRRX1
HGNC ID HGNC:9142
References
General References
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  4. Grueneberg DA, Natesan S, Alexandre C, Gilman MZ: Human and Drosophila homeodomain proteins that enhance the DNA-binding activity of serum response factor. Science. 1992 Aug 21;257(5073):1089-95. [PubMed:1509260 ]