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Showing Protein Antigen peptide transporter 2 (HMDBP10765)

IdentificationBiological propertiesGene propertiesProtein propertiesExternal linksReferencesXMLShow 1 metabolite
Identification
HMDB Protein ID HMDBP10765
Secondary Accession Numbers
  • 17033
Name Antigen peptide transporter 2
Synonyms
  1. APT2
  2. ATP-binding cassette sub-family B member 3
  3. PSF-2
  4. Peptide supply factor 2
  5. Peptide transporter PSF2
  6. Peptide transporter TAP2
  7. Peptide transporter involved in antigen processing 2
  8. Really interesting new gene 11 protein
Gene Name TAP2
Protein Type Unknown
Biological Properties
General Function Involved in ATP binding
Specific Function Involved in the transport of antigens from the cytoplasm to the endoplasmic reticulum for association with MHC class I molecules. Also acts as a molecular scaffold for the final stage of MHC class I folding, namely the binding of peptide. Nascent MHC class I molecules associate with TAP via tapasin. Inhibited by the covalent attachment of herpes simplex virus ICP47 protein, which blocks the peptide-binding site of TAP. Inhibited by human cytomegalovirus US6 glycoprotein, which binds to the lumenal side of the TAP complex and inhibits peptide translocation by specifically blocking ATP-binding to TAP1 and prevents the conformational rearrangement of TAP induced by peptide binding. Inhibited by human adenovirus E3-19K glycoprotein, which binds the TAP complex and acts as a tapasin inhibitor, preventing MHC class I/TAP association
Pathways Not Available
Reactions Not Available
GO Classification
Component
membrane
cell part
membrane part
intrinsic to membrane
integral to membrane
Function
active transmembrane transporter activity
primary active transmembrane transporter activity
p-p-bond-hydrolysis-driven transmembrane transporter activity
atpase activity, coupled to transmembrane movement of substances
binding
nucleotide binding
catalytic activity
hydrolase activity
nucleoside binding
purine nucleoside binding
adenyl nucleotide binding
adenyl ribonucleotide binding
atp binding
peptide transporter activity
transmembrane transporter activity
atpase activity
transporter activity
substrate-specific transporter activity
nucleoside-triphosphatase activity
hydrolase activity, acting on acid anhydrides
hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides
pyrophosphatase activity
Process
peptide transport
establishment of localization
transport
transmembrane transport
Cellular Location
  1. Endoplasmic reticulum membrane
  2. Multi-pass membrane protein
Gene Properties
Chromosome Location Chromosome:6
Locus 6p21.3
SNPs TAP2
Gene Sequence 
>4062 bp
ATGCGGCTCCCTGACCTGAGACCCTGGACCTCCCTGCTGCTGGTGGACGCGGCTTTACTG
TGGCTGCTTCAGGGCCCTCTGGGGACTTTGCTTCCTCAAGGGCTGCCAGGACTATGGCTG
GAGGGGACCCTGCGGCTGGGAGGGCTGTGGGGGCTGCTAAAGCTAAGAGGGCTGCTGGGA
TTTGTGGGGACACTGCTGCTCCCGCTCTGTCTGGCCACCCCCCTGACTGTCTCCCTGAGA
GCCCTGGTCGCGGGGGCCTCACGTGCTCCCCCAGCCAGAGTCGCTTCAGCCCCTTGGAGC
TGGCTGCTGGTGGGGTACGGGGCTGCGGGGCTCAGCTGGTCACTGTGGGCTGTTCTGAGC
CCTCCTGGAGCCCAGGAGAAGGAGCAGGACCAGGTGAACAACAAAGTCTTGATGTGGAGG
CTGCTGAAGCTCTCCAGGCCGGACCTGCCTCTCCTCGTTGCCGCCTTCTTCTTCCTTGTC
CTTGCTGTTTTGGGTGAGACATTAATCCCTCACTATTCTGGTCGTGTGATTGACATCCTG
GGAGGTGATTTTGACCCCCATGCCTTTGCCAGTGCCATCTTCTTCATGTGCCTCTTCTCC
TTTGGCAGCTCACTGTCTGCAGGCTGCCGAGGAGGCTGCTTCACCTACACCATGTCTCGA
ATCAACTTGCGGATCCGGGAGCAGCTTTTCTCCTCCCTGCTGCGCCAGGACCTCGGTTTC
TTCCAGGAGACTAAGACAGGGGAGCTGAACTCACGGCTGAGCTCGGATACCACCCTGATG
AGTAACTGGCTTCCTTTAAATGCCAATGTGCTCTTGCGAAGCCTGGTGAAAGTGGTGGGG
CTGTATGGCTTCATGCTCAGCATATCGCCTCGACTCACCCTCCTTTCTCTGCTGCACATG
CCCTTCACAATAGCAGCGGAGAAGGTGTACAACACCCGCCATCAGGAAGTGCTTCGGGAG
ATCCAGGATGCAGTGGCCAGGGCGGGGCAGGTGGTGCGGGAAGCCGTTGGAGGGCTGCAG
ACCGTTCGCAGTTTTGGGGCCGAGGAGCATGAAGTCTGTCGCTATAAAGAGGCCCTTGAA
CAATGTCGGCAGCTGTATTGGCGGAGAGACCTGGAACGCGCCTTGTACCTGCTCATAAGG
AGGGTGCTGCACTTGGGGGTGCAGATGCTGATGCTGAGCTGTGGGCTGCAGCAGATGCAG
GATGGGGAGCTCACCCAGGGCAGCCTGCTTTCCTTTATGATCTACCAGGAGAGCGTGGGG
AGCTATGTGCAGACCCTGGTATACATATATGGGGATATGCTCAGCAACGTGGGAGCTGCA
GAGAAGGTTTTCTCCTACATGGACCGACAGCCAAATCTGCCTTCACCTGGCACGCTTGCC
CCCACCACTCTGCAGGGGGTTGTGAAATTCCAAGACGTCTCCTTTGCATATCCCAATCGC
CCTGACAGGCCTGTGCTCAAGGGGCTGACGTTTACCCTACGTCCTGGTGAGGTGACGGCG
CTGGTGGGACCCAATGGGTCTGGGAAGAGCACAGTGGCTGCCCTGCTGCAGAATCTGTAC
CAGCCCACAGGGGGACAGGTGCTGCTGGATGAAAAGCCCATCTCACAGTATGAACACTGC
TACCTGCACAGCCAGGTGGTTTCAGTTGGGCAGGAGCCTGTGCTGTTCTCCGGTTCTGTG
AGGAACAACATTACTTATGGGCTGCAGAGCTGCGAAGATGATAAGGTGATGGCGGCTGCC
CAGGCTGCCCACGCAGATGACTTCATCCAGGAAATGGAGCATGGAATATACACAGATGTA
GGGGAGAAGGGAAGCCAGCTGGCTGCGGGACAGAAACAACGTCTGGCCATTGCCCGGGCC
CTTGTACGAGACCCGCGGGTCCTCATCCTGGATGAGGCTACTAGTGCCCTAGATGTGCAG
TGCGAGCAGGCCCTGCAGGACTGGAATTCCCGTGGGGATCGCACAGTGCTGGTGATTGCT
CACAGGCTGCAGACAGTTCAGCGCGCCCACCAGATCCTGGTGCTCCAGGAGGGCAAGCTG
CAGAAGCTTGCCCAGCTCTAG
Protein Properties
Number of Residues 686
Molecular Weight 75663.2
Theoretical pI 8.1
Pfam Domain Function
Signals
  • None
Transmembrane Regions
  • 7-27
  • 57-77
  • 99-119
  • 149-169
  • 188-208
  • 267-287
  • 294-314
  • 375-395
  • 409-429
Protein Sequence 
>Antigen peptide transporter 2
MRLPDLRPWTSLLLVDAALLWLLQGPLGTLLPQGLPGLWLEGTLRLGGLWGLLKLRGLLG
FVGTLLLPLCLATPLTVSLRALVAGASRAPPARVASAPWSWLLVGYGAAGLSWSLWAVLS
PPGAQEKEQDQVNNKVLMWRLLKLSRPDLPLLVAAFFFLVLAVLGETLIPHYSGRVIDIL
GGDFDPHAFASAIFFMCLFSFGSSLSAGCRGGCFTYTMSRINLRIREQLFSSLLRQDLGF
FQETKTGELNSRLSSDTTLMSNWLPLNANVLLRSLVKVVGLYGFMLSISPRLTLLSLLHM
PFTIAAEKVYNTRHQEVLREIQDAVARAGQVVREAVGGLQTVRSFGAEEHEVCRYKEALE
QCRQLYWRRDLERALYLLVRRVLHLGVQMLMLSCGLQQMQDGELTQGSLLSFMIYQESVG
SYVQTLVYIYGDMLSNVGAAEKVFSYMDRQPNLPSPGTLAPTTLQGVVKFQDVSFAYPNR
PDRPVLKGLTFTLRPGEVTALVGPNGSGKSTVAALLQNLYQPTGGQVLLDEKPISQYEHC
YLHSQVVSVGQEPVLFSGSVRNNIAYGLQSCEDDKVMAAAQAAHADDFIQEMEHGIYTDV
GEKGSQLAAGQKQRLAIARALVRDPRVLILDEATSALDVQCEQALQDWNSRGDRTVLVIA
HRLQTVQRAHQILVLQEGKLQKLAQL
GenBank ID Protein 168983733
UniProtKB/Swiss-Prot ID Q03519
UniProtKB/Swiss-Prot Entry Name TAP2_HUMAN
PDB IDs Not Available
GenBank Gene ID CT009502
GeneCard ID TAP2
GenAtlas ID TAP2
HGNC ID HGNC:44
References
General References
  1. Mungall AJ, Palmer SA, Sims SK, Edwards CA, Ashurst JL, Wilming L, Jones MC, Horton R, Hunt SE, Scott CE, Gilbert JG, Clamp ME, Bethel G, Milne S, Ainscough R, Almeida JP, Ambrose KD, Andrews TD, Ashwell RI, Babbage AK, Bagguley CL, Bailey J, Banerjee R, Barker DJ, Barlow KF, Bates K, Beare DM, Beasley H, Beasley O, Bird CP, Blakey S, Bray-Allen S, Brook J, Brown AJ, Brown JY, Burford DC, Burrill W, Burton J, Carder C, Carter NP, Chapman JC, Clark SY, Clark G, Clee CM, Clegg S, Cobley V, Collier RE, Collins JE, Colman LK, Corby NR, Coville GJ, Culley KM, Dhami P, Davies J, Dunn M, Earthrowl ME, Ellington AE, Evans KA, Faulkner L, Francis MD, Frankish A, Frankland J, French L, Garner P, Garnett J, Ghori MJ, Gilby LM, Gillson CJ, Glithero RJ, Grafham DV, Grant M, Gribble S, Griffiths C, Griffiths M, Hall R, Halls KS, Hammond S, Harley JL, Hart EA, Heath PD, Heathcott R, Holmes SJ, Howden PJ, Howe KL, Howell GR, Huckle E, Humphray SJ, Humphries MD, Hunt AR, Johnson CM, Joy AA, Kay M, Keenan SJ, Kimberley AM, King A, Laird GK, Langford C, Lawlor S, Leongamornlert DA, Leversha M, Lloyd CR, Lloyd DM, Loveland JE, Lovell J, Martin S, Mashreghi-Mohammadi M, Maslen GL, Matthews L, McCann OT, McLaren SJ, McLay K, McMurray A, Moore MJ, Mullikin JC, Niblett D, Nickerson T, Novik KL, Oliver K, Overton-Larty EK, Parker A, Patel R, Pearce AV, Peck AI, Phillimore B, Phillips S, Plumb RW, Porter KM, Ramsey Y, Ranby SA, Rice CM, Ross MT, Searle SM, Sehra HK, Sheridan E, Skuce CD, Smith S, Smith M, Spraggon L, Squares SL, Steward CA, Sycamore N, Tamlyn-Hall G, Tester J, Theaker AJ, Thomas DW, Thorpe A, Tracey A, Tromans A, Tubby B, Wall M, Wallis JM, West AP, White SS, Whitehead SL, Whittaker H, Wild A, Willey DJ, Wilmer TE, Wood JM, Wray PW, Wyatt JC, Young L, Younger RM, Bentley DR, Coulson A, Durbin R, Hubbard T, Sulston JE, Dunham I, Rogers J, Beck S: The DNA sequence and analysis of human chromosome 6. Nature. 2003 Oct 23;425(6960):805-11. [PubMed:14574404 ]
  2. Gerhard DS, Wagner L, Feingold EA, Shenmen CM, Grouse LH, Schuler G, Klein SL, Old S, Rasooly R, Good P, Guyer M, Peck AM, Derge JG, Lipman D, Collins FS, Jang W, Sherry S, Feolo M, Misquitta L, Lee E, Rotmistrovsky K, Greenhut SF, Schaefer CF, Buetow K, Bonner TI, Haussler D, Kent J, Kiekhaus M, Furey T, Brent M, Prange C, Schreiber K, Shapiro N, Bhat NK, Hopkins RF, Hsie F, Driscoll T, Soares MB, Casavant TL, Scheetz TE, Brown-stein MJ, Usdin TB, Toshiyuki S, Carninci P, Piao Y, Dudekula DB, Ko MS, Kawakami K, Suzuki Y, Sugano S, Gruber CE, Smith MR, Simmons B, Moore T, Waterman R, Johnson SL, Ruan Y, Wei CL, Mathavan S, Gunaratne PH, Wu J, Garcia AM, Hulyk SW, Fuh E, Yuan Y, Sneed A, Kowis C, Hodgson A, Muzny DM, McPherson J, Gibbs RA, Fahey J, Helton E, Ketteman M, Madan A, Rodrigues S, Sanchez A, Whiting M, Madari A, Young AC, Wetherby KD, Granite SJ, Kwong PN, Brinkley CP, Pearson RL, Bouffard GG, Blakesly RW, Green ED, Dickson MC, Rodriguez AC, Grimwood J, Schmutz J, Myers RM, Butterfield YS, Griffith M, Griffith OL, Krzywinski MI, Liao N, Morin R, Palmquist D, Petrescu AS, Skalska U, Smailus DE, Stott JM, Schnerch A, Schein JE, Jones SJ, Holt RA, Baross A, Marra MA, Clifton S, Makowski KA, Bosak S, Malek J: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). Genome Res. 2004 Oct;14(10B):2121-7. [PubMed:15489334 ]
  3. Beck S, Abdulla S, Alderton RP, Glynne RJ, Gut IG, Hosking LK, Jackson A, Kelly A, Newell WR, Sanseau P, Radley E, Thorpe KL, Trowsdale J: Evolutionary dynamics of non-coding sequences within the class II region of the human MHC. J Mol Biol. 1996 Jan 12;255(1):1-13. [PubMed:8568858 ]
  4. Beck S, Kelly A, Radley E, Khurshid F, Alderton RP, Trowsdale J: DNA sequence analysis of 66 kb of the human MHC class II region encoding a cluster of genes for antigen processing. J Mol Biol. 1992 Nov 20;228(2):433-41. [PubMed:1453454 ]
  5. Bahram S, Arnold D, Bresnahan M, Strominger JL, Spies T: Two putative subunits of a peptide pump encoded in the human major histocompatibility complex class II region. Proc Natl Acad Sci U S A. 1991 Nov 15;88(22):10094-8. [PubMed:1946428 ]
  6. Ahn K, Meyer TH, Uebel S, Sempe P, Djaballah H, Yang Y, Peterson PA, Fruh K, Tampe R: Molecular mechanism and species specificity of TAP inhibition by herpes simplex virus ICP47. EMBO J. 1996 Jul 1;15(13):3247-55. [PubMed:8670825 ]
  7. Nijenhuis M, Hammerling GJ: Multiple regions of the transporter associated with antigen processing (TAP) contribute to its peptide binding site. J Immunol. 1996 Dec 15;157(12):5467-77. [PubMed:8955196 ]
  8. Ahn K, Gruhler A, Galocha B, Jones TR, Wiertz EJ, Ploegh HL, Peterson PA, Yang Y, Fruh K: The ER-luminal domain of the HCMV glycoprotein US6 inhibits peptide translocation by TAP. Immunity. 1997 May;6(5):613-21. [PubMed:9175839 ]
  9. Bennett EM, Bennink JR, Yewdell JW, Brodsky FM: Cutting edge: adenovirus E19 has two mechanisms for affecting class I MHC expression. J Immunol. 1999 May 1;162(9):5049-52. [PubMed:10227971 ]
  10. Hewitt EW, Gupta SS, Lehner PJ: The human cytomegalovirus gene product US6 inhibits ATP binding by TAP. EMBO J. 2001 Feb 1;20(3):387-96. [PubMed:11157746 ]
  11. Horst D, van Leeuwen D, Croft NP, Garstka MA, Hislop AD, Kremmer E, Rickinson AB, Wiertz EJ, Ressing ME: Specific targeting of the EBV lytic phase protein BNLF2a to the transporter associated with antigen processing results in impairment of HLA class I-restricted antigen presentation. J Immunol. 2009 Feb 15;182(4):2313-24. doi: 10.4049/jimmunol.0803218. [PubMed:19201886 ]
  12. Colonna M, Bresnahan M, Bahram S, Strominger JL, Spies T: Allelic variants of the human putative peptide transporter involved in antigen processing. Proc Natl Acad Sci U S A. 1992 May 1;89(9):3932-6. [PubMed:1570316 ]
  13. Powis SH, Mockridge I, Kelly A, Kerr LA, Glynne R, Gileadi U, Beck S, Trowsdale J: Polymorphism in a second ABC transporter gene located within the class II region of the human major histocompatibility complex. Proc Natl Acad Sci U S A. 1992 Feb 15;89(4):1463-7. [PubMed:1741401 ]
  14. Powis SH, Tonks S, Mockridge I, Kelly AP, Bodmer JG, Trowsdale J: Alleles and haplotypes of the MHC-encoded ABC transporters TAP1 and TAP2. Immunogenetics. 1993;37(5):373-80. [PubMed:8428770 ]
  15. Yan G, Shi L, Faustman D: Novel splicing of the human MHC-encoded peptide transporter confers unique properties. J Immunol. 1999 Jan 15;162(2):852-9. [PubMed:9916708 ]
  16. Cano P, Baxter-Lowe LA: Novel human TAP2*103 allele shows further polymorphism in the ATP-binding domain. Tissue Antigens. 1995 Feb;45(2):139-42. [PubMed:7792761 ]
  17. Tang J, Allen S, Karita E, Musonda R, Kaslow RA: New TAP2 polymorphisms in Africans. Tissue Antigens. 1998 May;51(5):556-62. [PubMed:9672156 ]
  18. Singal DP, Ye M, Qiu X, D'Souza M: Polymorphisms in the TAP2 gene and their association with rheumatoid arthritis. Clin Exp Rheumatol. 1994 Jan-Feb;12(1):29-33. [PubMed:8162639 ]
  19. de la Salle H, Hanau D, Fricker D, Urlacher A, Kelly A, Salamero J, Powis SH, Donato L, Bausinger H, Laforet M, et al.: Homozygous human TAP peptide transporter mutation in HLA class I deficiency. Science. 1994 Jul 8;265(5169):237-41. [PubMed:7517574 ]
  20. Kumagai S, Kanagawa S, Morinobu A, Takada M, Nakamura K, Sugai S, Maruya E, Saji H: Association of a new allele of the TAP2 gene, TAP2*Bky2 (Val577), with susceptibility to Sjogren's syndrome. Arthritis Rheum. 1997 Sep;40(9):1685-92. [PubMed:9324024 ]
  21. Tang J, Freedman DO, Allen S, Karita E, Musonda R, Braga C, Jamieson BD, Louie L, Kaslow RA: Genotyping TAP2 variants in North American Caucasians, Brazilians, and Africans. Genes Immun. 2001 Feb;2(1):32-40. [PubMed:11294565 ]