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Showing Protein CUGBP Elav-like family member 2 (HMDBP10768)

IdentificationBiological propertiesGene propertiesProtein propertiesExternal linksReferencesXMLShow 2 metabolites
Identification
HMDB Protein ID HMDBP10768
Secondary Accession Numbers
  • 17036
Name CUGBP Elav-like family member 2
Synonyms
  1. Bruno-like protein 3
  2. CELF-2
  3. CUG triplet repeat RNA-binding protein 2
  4. CUG-BP- and ETR-3-like factor 2
  5. CUG-BP2
  6. ELAV-type RNA-binding protein 3
  7. ETR-3
  8. Neuroblastoma apoptosis-related RNA-binding protein
  9. RNA-binding protein BRUNOL-3
  10. hNAPOR
Gene Name CELF2
Protein Type Unknown
Biological Properties
General Function Involved in nucleotide binding
Specific Function RNA-binding protein implicated in the regulation of several post-transcriptional events. Involved in pre-mRNA alternative splicing, mRNA translation and stability. Mediates exon inclusion and/or exclusion in pre-mRNA that are subject to tissue-specific and developmentally regulated alternative splicing. Specifically activates exon 5 inclusion of TNNT2 in embryonic, but not adult, skeletal muscle. Activates TNNT2 exon 5 inclusion by antagonizing the repressive effect of PTB. Acts as both an activator and repressor of a pair of coregulated exons:promotes inclusion of the smooth muscle (SM) exon but exclusion of the non-muscle (NM) exon in actinin pre-mRNAs. Promotes inclusion of exonS 21 and exclusion of exon 5 of the NMDA receptor R1 pre- mRNA. Involved in the apoB RNA editing activity. Increases COX2 mRNA stability and inhibits COX2 mRNA translation in epithelial cells after radiation injury. Modulates the cellular apoptosis program by regulating COX2-mediated prostaglandin E2 (PGE2) expression. Binds to (CUG)n triplet repeats in the 3'-UTR of transcripts such as DMPK. Binds to the muscle-specific splicing enhancer (MSE) intronic sites flanking the TNNT2 alternative exon 5. Binds preferentially to UG-rich sequences, in particular UG repeat and UGUU motifs. Binds to apoB mRNA, specifically to AU-rich sequences located immediatly upstream of the edited cytidine. Binds AU-rich sequences in the 3'-UTR of COX2 mRNA. Binds to an intronic RNA element responsible for the silencing of exon 21 splicing. Binds to (CUG)n repeats
Pathways Not Available
Reactions Not Available
GO Classification
Function
binding
nucleotide binding
nucleic acid binding
rna binding
Cellular Location
  1. Nucleus
  2. Cytoplasm
Gene Properties
Chromosome Location Chromosome:1
Locus 10p13
SNPs CELF2
Gene Sequence 
>1527 bp
ATGCGCTGTCCCAAATCCGCTGTTACTATGAGAAATGAAGAGCTGCTTTTAAGTAACGGC
ACAGCCAACAAGATGAACGGAGCTTTGGATCACTCAGACCAACCAGACCCAGATGCCATT
AAGATGTTTGTCGGACAGATCCCCCGGTCATGGTCGGAAAAGGAGCTGAAAGAACTTTTT
GAGCCTTACGGAGCCGTCTACCAGATCAACGTCCTCCGGGACCGGAGTCAGAACCCTCCG
CAGAGTAAAGGTTGTTGTTTCGTAACATTTTATACAAGAAAAGCTGCACTTGAGGCCCAG
AATGCACTGCACAATATTAAAACTTTACCTGGGATGCATCATCCCATTCAGATGAAACCT
GCAGATAGTGAAAAGTCCAACGCTGTGGAAGACAGAAAATTGTTCATAGGAATGGTATCG
AAGAAATGTAATGAGAACGACATCAGGGTGATGTTCTCTCCATTTGGCCAGATAGAAGAA
TGCCGGATCCTCCGGGGACCTGATGGGCTGAGTCGAGGCTGTGCGTTTGTCACATTTTCT
ACAAGGGCAATGGCACAGAATGCAATCAAAGCCATGCATCAGTCTCAGACCATGGAGGGC
TGCTCTTCACCTATCGTGGTGAAGTTTGCTGACACTCAGAAGGACAAAGAGCAAAGGCGC
CTCCAGCAGCAGCTCGCTCAGCAGATGCAGCAGCTCAACACTGCCACCTGGGGGAACCTG
ACAGGGCTGGGCGGACTGACCCCACAGTATCTGGCGCTCCTGCAGCAGGCCACCTCCTCC
AGCAACCTGGGTGCGTTCAGCGGCATTCAACAAATGGCAGGCATGAATGCTTTACAGTTG
CAGAACCTGGCGACGCTGGCTGCTGCTGCAGCTGCGGCCCAGACCTCAGCCACCAGCACC
AATGCAAACCCTCTCTCTACCACGAGCAGCGCCCTGGGAGCCCTCACGAGTCCCGTGGCT
GCTTCAACCCCCAACTCCACTGCTGGTGCAGCCATGAACTCCTTGACCTCTCTCGGGACT
CTGCAAGGACTGGCTGGAGCCACTGTTGGACTGAATAATATTAATGCACTAGCAGGTATG
GCGGCTCTGAATGGAGGACTTGGCGCCACAGGCTTGACGAATGGCACGGCTGGCACCATG
GACGCCCTCACCCAGGCCTACTCAGGAATTCAACAGTACGCAGCCGCCGCGCTGCCCACT
CTGTACAGCCAGAGCCTGCTGCAGCAGCAGAGCGCTGCAGGCAGCCAGAAGGAAGGTCCA
GAGGGGGCAAACCTCTTTATTTACCACCTTCCACAGGAATTTGGAGACCAGGACATTCTG
CAGATGTTCATGCCTTTTGGAAATGTTATCTCTGCTAAAGTCTTCATTGACAAACAGACC
AATCTGAGCAAGTGCTTTGGTTTTGTTAGCTACGACAATCCAGTCTCTGCACAAGCTGCT
ATCCAAGCTATGAATGGCTTTCAGATCGGCATGAAACGCTTGAAGGTGCAGCTGAAGCGT
TCCAAAAACGACAGCAAACCTTACTGA
Protein Properties
Number of Residues 508
Molecular Weight 54284.4
Theoretical pI 9.01
Pfam Domain Function
Signals
  • None
Transmembrane Regions
  • None
Protein Sequence 
>CUGBP Elav-like family member 2
MRCPKSAVTMRNEELLLSNGTANKMNGALDHSDQPDPDAIKMFVGQIPRSWSEKELKELF
EPYGAVYQINVLRDRSQNPPQSKGCCFVTFYTRKAALEAQNALHNIKTLPGMHHPIQMKP
ADSEKSNAVEDRKLFIGMVSKKCNENDIRVMFSPFGQIEECRILRGPDGLSRGCAFVTFS
TRAMAQNAIKAMHQSQTMEGCSSPIVVKFADTQKDKEQRRLQQQLAQQMQQLNTATWGNL
TGLGGLTPQYLALLQQATSSSNLGAFSGIQQMAGMNALQLQNLATLAAAAAAAQTSATST
NANPLSTTSSALGALTSPVAASTPNSTAGAAMNSLTSLGTLQGLAGATVGLNNINALAGM
AALNGGLGATGLTNGTAGTMDALTQAYSGIQQYAAAALPTLYSQSLLQQQSAAGSQKEGP
EGANLFIYHLPQEFGDQDILQMFMPFGNVISAKVFIDKQTNLSKCFGFVSYDNPVSAQAA
IQAMNGFQIGMKRLKVQLKRSKNDSKPY
GenBank ID Protein 68303647
UniProtKB/Swiss-Prot ID O95319
UniProtKB/Swiss-Prot Entry Name CELF2_HUMAN
PDB IDs Not Available
GenBank Gene ID NM_001025077.2
GeneCard ID CELF2
GenAtlas ID CELF2
HGNC ID HGNC:2550
References
General References
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