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Identification
HMDB Protein ID HMDBP10795
Secondary Accession Numbers
  • 17069
Name Choline transporter-like protein 2
Synonyms
  1. Solute carrier family 44 member 2
Gene Name SLC44A2
Protein Type Transporter
Biological Properties
General Function Involved in choline transmembrane transporter activity
Specific Function Isoform 1, but not isoform 3, exhibits some choline transporter activity.
Pathways
  • Sarcosine Oncometabolite Pathway
Reactions Not Available
GO Classification
Biological Process
phosphatidylcholine biosynthetic process
positive regulation of I-kappaB kinase/NF-kappaB cascade
Cellular Component
plasma membrane
integral to membrane
Molecular Function
signal transducer activity
choline transmembrane transporter activity
Cellular Location
  1. Membrane
  2. Multi-pass membrane protein
Gene Properties
Chromosome Location 19
Locus 19p13.1
SNPs SLC44A2
Gene Sequence
>2121 bp
ATGGGGGACGAGCGGCCCCACTACTACGGGAAACACGGAACGCCACAGAAGTATGATCCC
ACTTTCAAAGGACCCATTTACAATAGGGGCTGCACGGATATCATATGCTGTGTGTTCCTG
CTCCTGGCCATTGTGGGCTACGTGGCTGTAGGCATCATAGCCTGGACTCATGGAGACCCT
CGAAAGGTGATCTACCCCACTGATAGCCGGGGCGAGTTCTGCGGGCAGAAGGGCACAAAA
AACGAGAACAAACCCTATCTGTTTTATTTCAACATTGTGAAATGTGCCAGCCCCCTGGTT
CTGCTGGAATTCCAATGTCCCACTCCCCAGATCTGCGTGGAAAAATGCCCCGACCGCTAC
CTCACGTACCTGAATGCTCGCAGCTCCCGGGACTTTGAGTACTATAAGCAGTTCTGTGTT
CCTGGCTTCAAGAACAATAAAGGAGTGGCTGAGGTGCTTCGAGATGGTGACTGCCCTGCT
GTCCTCATCCCCAGCAAACCCTTGGCCCGGAGATGCTTCCCCGCTATCCACGCCTACAAG
GGTGTCCTGATGGTGGGCAATGAGACGACCTATGAGGATGGGCATGGCTCCCGGAAAAAC
ATCACAGACCTGGTGGAGGGCGCCAAGAAAGCCAATGGAGTCCTAGAGGCGCGGCAACTC
GCCATGCGCATATTTGAAGATTACACCGTCTCTTGGTACTGGATTATCATAGGCCTGGTC
ATTGCCATGGCGATGAGCCTCCTGTTCATCATCCTGCTTCGCTTCCTGGCTGGTATTATG
GTCTGGGTGATGATCATCATGGTGATTCTGGTGCTGGGCTACGGAATATTTCACTGCTAC
ATGGAGTACTCCCGACTGCGTGGTGAGGCCGGCTCTGATGTCTCTTTGGTGGACCTCGGC
TTTCAGACGGATTTCCGGGTGTACCTGCACTTACGGCAGACCTGGTTGGCCTTTATGATC
ATTCTGAGTATCCTTGAAGTCATTATCATCTTGCTGCTCATCTTTCTCCGGAAGAGAATT
CTCATCGCGATTGCACTCATCAAAGAAGCCAGCAGGGCTGTGGGATACGTCATGTGCTCC
TTGCTCTACCCACTGGTCACCTTCTTCTTGCTGTGCCTCTGCATCGCCTACTGGGCCAGC
ACTGCTGTCTTCCTGTCCACTTCCAACGAAGCGGTCTATAAGATCTTTGATGACAGCCCC
TGCCCATTTACTGCGAAAACCTGCAACCCAGAGACCTTCCCCTCCTCCAATGAGTCCCGC
CAATGCCCCAATGCCCGTTGCCAGTTCGCCTTCTACGGTGGTGAGTCGGGCTACCACCGG
GCCCTGCTGGGCCTGCAGATCTTCAATGCCTTCATGTTCTTCTGGTTGGCCAACTTCGTG
CTGGCGCTGGGCCAGGTCACGCTGGCCGGGGCCTTTGCCTCCTATTACTGGGCCCTGCGC
AAGCCGGACGACCTGCCGGCCTTCCCGCTCTTCTCTGCCTTTGGCCGGGCGCTCAGGTAC
CACACAGGCTCCCTGGCCTTTGGNGCGCTCATCCTGGCCATTGTGCAGATCATCCGTGTG
ATACTCGAGTACCTGGATCAGCGGCTGAAAGGTGCAGAGAACAAGTTTGCCAAGTGCCTC
ATGACCTGTCTCAAATGCTGCTTCTGGTGCCTGGAGAAGTTCATCAAATTCCTTAATAGG
AATGCCTACATCATGATTGCCATCTACGGCACCAATTTCTGCACCTCGGCCAGGAATGCC
TTCTTCCTGCTCATGAGAAACATCATCAGAGTGGCTGTCCTGGATAAAGTTACTGACTTC
CTCTTCCTGTTGGGCAAACTTCTGATCGTTGGTAGTGTGGGGATCCTGGCTTTCTTCTTC
TTCACCCACCGTATCAGGATCGTGCAGGATACAGCACCACCCCTCAATTATTACTGGGTT
CCTATACTGACGGTGATCGTTGGCTCCTACTTGATTGCACACGGTTTCTTCAGCGTCTAT
GGCATGTGTGTGGACACGCTGTTCCTCTGCTTCTTGGAGGACCTGGAGAGGAATGACGGC
TCGGCCGAGAGGCCTTACTTCATGTCTTCCACCCTCAAGAAACTCTTGAACAAGACCAAC
AAGAAGGCAGCGGAGTCCTGA
Protein Properties
Number of Residues 706
Molecular Weight 79845.355
Theoretical pI 8.53
Pfam Domain Function
Signals Not Available
Transmembrane Regions Not Available
Protein Sequence
>Choline transporter-like protein 2
MGDERPHYYGKHGTPQKYDPTFKGPIYNRGCTDIICCVFLLLAIVGYVAVGIIAWTHGDP
RKVIYPTDSRGEFCGQKGTKNENKPYLFYFNIVKCASPLVLLEFQCPTPQICVEKCPDRY
LTYLNARSSRDFEYYKQFCVPGFKNNKGVAEVLRDGDCPAVLIPSKPLARRCFPAIHAYK
GVLMVGNETTYEDGHGSRKNITDLVEGAKKANGVLEARQLAMRIFEDYTVSWYWIIIGLV
IAMAMSLLFIILLRFLAGIMVWVMIIMVILVLGYGIFHCYMEYSRLRGEAGSDVSLVDLG
FQTDFRVYLHLRQTWLAFMIILSILEVIIILLLIFLRKRILIAIALIKEASRAVGYVMCS
LLYPLVTFFLLCLCIAYWASTAVFLSTSNEAVYKIFDDSPCPFTAKTCNPETFPSSNESR
QCPNARCQFAFYGGESGYHRALLGLQIFNAFMFFWLANFVLALGQVTLAGAFASYYWALR
KPDDLPAFPLFSAFGRALRYHTGSLAFGALILAIVQIIRVILEYLDQRLKAAENKFAKCL
MTCLKCCFWCLEKFIKFLNRNAYIMIAIYGTNFCTSARNAFFLLMRNIIRVAVLDKVTDF
LFLLGKLLIVGSVGILAFFFFTHRIRIVQDTAPPLNYYWVPILTVIVGSYLIAHGFFSVY
GMCVDTLFLCFLEDLERNDGSAERPYFMSSTLKKLLNKTNKKAAES
GenBank ID Protein 6996444
UniProtKB/Swiss-Prot ID Q8IWA5
UniProtKB/Swiss-Prot Entry Name CTL2_HUMAN
PDB IDs Not Available
GenBank Gene ID AJ245621
GeneCard ID SLC44A2
GenAtlas ID SLC44A2
HGNC ID HGNC:17292
References
General References
  1. Chen R, Jiang X, Sun D, Han G, Wang F, Ye M, Wang L, Zou H: Glycoproteomics analysis of human liver tissue by combination of multiple enzyme digestion and hydrazide chemistry. J Proteome Res. 2009 Feb;8(2):651-61. doi: 10.1021/pr8008012. [PubMed:19159218 ]
  2. Wollscheid B, Bausch-Fluck D, Henderson C, O'Brien R, Bibel M, Schiess R, Aebersold R, Watts JD: Mass-spectrometric identification and relative quantification of N-linked cell surface glycoproteins. Nat Biotechnol. 2009 Apr;27(4):378-86. doi: 10.1038/nbt.1532. Epub 2009 Apr 6. [PubMed:19349973 ]
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  5. Bechtel S, Rosenfelder H, Duda A, Schmidt CP, Ernst U, Wellenreuther R, Mehrle A, Schuster C, Bahr A, Blocker H, Heubner D, Hoerlein A, Michel G, Wedler H, Kohrer K, Ottenwalder B, Poustka A, Wiemann S, Schupp I: The full-ORF clone resource of the German cDNA Consortium. BMC Genomics. 2007 Oct 31;8:399. [PubMed:17974005 ]
  6. Otsuki T, Ota T, Nishikawa T, Hayashi K, Suzuki Y, Yamamoto J, Wakamatsu A, Kimura K, Sakamoto K, Hatano N, Kawai Y, Ishii S, Saito K, Kojima S, Sugiyama T, Ono T, Okano K, Yoshikawa Y, Aotsuka S, Sasaki N, Hattori A, Okumura K, Nagai K, Sugano S, Isogai T: Signal sequence and keyword trap in silico for selection of full-length human cDNAs encoding secretion or membrane proteins from oligo-capped cDNA libraries. DNA Res. 2005;12(2):117-26. [PubMed:16303743 ]
  7. O'Regan S, Traiffort E, Ruat M, Cha N, Compaore D, Meunier FM: An electric lobe suppressor for a yeast choline transport mutation belongs to a new family of transporter-like proteins. Proc Natl Acad Sci U S A. 2000 Feb 15;97(4):1835-40. [PubMed:10677542 ]
  8. Nair TS, Kozma KE, Hoefling NL, Kommareddi PK, Ueda Y, Gong TW, Lomax MI, Lansford CD, Telian SA, Satar B, Arts HA, El-Kashlan HK, Berryhill WE, Raphael Y, Carey TE: Identification and characterization of choline transporter-like protein 2, an inner ear glycoprotein of 68 and 72 kDa that is the target of antibody-induced hearing loss. J Neurosci. 2004 Feb 18;24(7):1772-9. [PubMed:14973250 ]
  9. Kommareddi PK, Nair TS, Raphael Y, Telian SA, Kim AH, Arts HA, El-Kashlan HK, Carey TE: Cochlin isoforms and their interaction with CTL2 (SLC44A2) in the inner ear. J Assoc Res Otolaryngol. 2007 Dec;8(4):435-46. Epub 2007 Oct 10. [PubMed:17926100 ]