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Identification
HMDB Protein ID HMDBP10846
Secondary Accession Numbers
  • 17136
Name Potassium voltage-gated channel subfamily A member 4
Synonyms
  1. HPCN2
  2. Voltage-gated K(+) channel HuKII
  3. Voltage-gated potassium channel HBK4
  4. Voltage-gated potassium channel HK1
  5. Voltage-gated potassium channel subunit Kv1.4
Gene Name KCNA4
Protein Type Unknown
Biological Properties
General Function Involved in protein binding
Specific Function Mediates the voltage-dependent potassium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a potassium-selective channel through which potassium ions may pass in accordance with their electrochemical gradient
Pathways Not Available
Reactions Not Available
GO Classification
Component
membrane
cell part
membrane part
ion channel complex
cation channel complex
potassium channel complex
voltage-gated potassium channel complex
macromolecular complex
intrinsic to membrane
protein complex
integral to membrane
Function
ion binding
cation binding
metal ion binding
binding
protein binding
transmembrane transporter activity
substrate-specific transmembrane transporter activity
ion transmembrane transporter activity
transporter activity
alkali metal ion binding
potassium ion binding
ion channel activity
cation channel activity
potassium channel activity
voltage-gated potassium channel activity
Process
establishment of localization
transport
transmembrane transport
monovalent inorganic cation transport
potassium ion transport
ion transport
cation transport
Cellular Location
  1. Membrane
  2. Multi-pass membrane protein
Gene Properties
Chromosome Location Chromosome:1
Locus 11p14
SNPs KCNA4
Gene Sequence
>1962 bp
ATGGAGGTTGCAATGGTGAGTGCGGAGAGCTCAGGGTGCAACAGTCACATGCCTTATGGT
TATGCTGCCCAGGCCCGGGCCCGGGAGCGGGAGAGGCTTGCTCACTCCAGGCGAGCTGCA
GCACGTGCTGTTGCAGCGGCCACAGCTGCTGTCGAAGGTAGCGGGGGTTCTGGTGGGGGC
TCCCACCACCACCACCAGTCACGCGGGGCCTGTACCTCCCATGACCCTCAGAGCAGCCGG
GGTAGTCGGGAGGAGGAGGCGACACGGTCTGAGAAGAAGAAAGCCCACTACCGGCAGAGC
AGCTTCCCTCATTGCTCTGACCTGATGCCCAGTGGCTCTGAGGAGAAGATCCTGAGGGAG
CTGAGTGAGGAGGAGGAAGATGAGGAGGAGGAGGAAGAGGAGGAAGAGGAGGGAAGGTTT
TACTATAGTGAAGATGACCATGGTGATGAGTGTTCCTACACGGATCTGCTGCCTCAGGAT
GAGGGCGGTGGCGGCTACAGTTCAGTCCGCTACAGTGACTGTTGTGAACGTGTGGTGATA
AATGTGTCAGGCCTACGCTTTGAGACCCAAATGAAAACTCTGGCCCAGTTTCCAGAGACT
TTGTTGGGAGACCCTGAAAAGAGGACTCAGTACTTTGACCCTTTGCGCAATGAGTATTTT
TTTGACAGGAACCGCCCCAGCTTTGATGCCATCTTGTATTATTATCAATCAGGAGGCCGC
CTGAAGAGGCCAGTCAATGTCCCCTTTGATATCTTCACTGAGGAGGTGAAGTTCTATCAG
TTGGGGGAGGAGGCCCTGTTGAAGTTTCGGGAGGACGAGGGCTTTGTGAGAGAAGAGGAA
GACAGGGCCCTCCCCGAGAATGAATTTAAAAAGCAGATTTGGCTCCTCTTTGAATATCCA
GAGAGCTCCGATCCTGCAAGGGGCATAGCCATTGTGTCCGTCCTGGTCATCTTAATCTCC
ATTGTCATCTTTTGCCTGGAAACCTTGCCTGAGTTTAGGGACGACAGGGATCTCGTCATG
GCACTGAGTGCTGGCGGGCATGGTGGGTTGTTGAATGATACTTCAGCACCCCATCTGGAG
AACTCAGGGCACACAATATTCAATGACCCCTTCTTCATCGTGGAAACAGTCTGTATTGTA
TGGTTTTCCTTTGAGTTTGTGGTTCGCTGCTTTGCTTGTCCCAGCCAAGCACTCTTCTTC
AAAAACATCATGAACATCATTGACATTGTCTCCATTTTGCCTTACTTCATCACACTGGGC
ACTGACCTGGCCCAGCAACAGGGGGGTGGCAATGGTCAGCAGCAGCAGGCCATGTCCTTT
GCCATCCTCAGAATCATTCGTCTGGTCCGAGTATTCCGGATCTTCAAACTCTCCAGGCAC
TCCAAAGGCCTGCAGATCCTGGGCCACACCCTCAGAGCCAGCATGCGGGAACTGGGCCTT
CTGATCTTCTTCCTCTTCATTGGGGTCATCCTCTTTTCTAGTGCTGTGTATTTTGCAGAG
GCGGATGAACCTACTACCCATTTCCAAAGCATCCCAGATGCATTTTGGTGGGCTGTGGTG
ACCATGACAACTGTGGGCTATGGGGACATGAAGCCCATCACTGTAGGGGGCAAGATTGTC
GGGGTCCTGTGTGCCATTGCGGGTGTCTTAACCATTGCTTTGCCAGTGCCAGTGATTGTC
TCTAACTTTAACTATTTCTACCACAGAGAGACTGAAAATGAGGAACAGACACAGCTAACG
CAGAATGCAGTCAGTTGTCCATACCTCCCCTCTAATTTGCTCAAGAAATTTCGGAGCTCT
ACTTCTTCTTCCCTGGGGGACAAGTCAGAGTATCTAGAGATGGAAGAAGGAGTTAAGGAA
TCTCTGTGTGCCAAGGAGGAGAAGTGTCAGGCCAAGGGGGATGACAGTGAGACAGATAAA
AACAACTGTTCTAATGCAAAGGCTGTGGAGACTGATGTGTGA
Protein Properties
Number of Residues 653
Molecular Weight 73287.6
Theoretical pI 4.67
Pfam Domain Function
Signals
  • None
Transmembrane Regions
  • 308-326
  • 371-392
  • 404-424
  • 443-461
  • 478-497
  • 539-561
Protein Sequence
>Potassium voltage-gated channel subfamily A member 4
MEVAMVSAESSGCNSHMPYGYAAQARARERERLAHSRRAAARAVAAATAAVEGSGGSGGG
SHHHHQSRGACTSHDPQSSRGSREEEATRSEKKKAHYRQSSFPHCSDLMPSGSEEKILRE
LSEEEEDEEEEEEEEEEGRFYYSEDDHGDECSYTDLLPQDEGGGGYSSVRYSDCCERVVI
NVSGLRFETQMKTLAQFPETLLGDPEKRTQYFDPLRNEYFFDRNRPSFDAILYYYQSGGR
LKRPVNVPFDIFTEEVKFYQLGEEALLKFREDEGFVREEEDRALPENEFKKQIWLLFEYP
ESSDPARGIAIVSVLVILISIVIFCLETLPEFRDDRDLVMALSAGGHGGLLNDTSAPHLE
NSGHTIFNDPFFIVETVCIVWFSFEFVVRCFACPSQALFFKNIMNIIDIVSILPYFITLG
TDLAQQQGGGNGQQQQAMSFAILRIIRLVRVFRIFKLSRHSKGLQILGHTLRASMRELGL
LIFFLFIGVILFSSAVYFAEADEPTTHFQSIPDAFWWAVVTMTTVGYGDMKPITVGGKIV
GVLCAIAGVLTIALPVPVIVSNFNYFYHRETENEEQTQLTQNAVSCPYLPSNLLKKFRSS
TSSSLGDKSEYLEMEEGVKESLCAKEEKCQAKGDDSETDKNNCSNAKAVETDV
GenBank ID Protein Not Available
UniProtKB/Swiss-Prot ID P22459
UniProtKB/Swiss-Prot Entry Name KCNA4_HUMAN
PDB IDs
GenBank Gene ID M55514
GeneCard ID KCNA4
GenAtlas ID KCNA4
HGNC ID HGNC:6222
References
General References
  1. Philipson LH, Hice RE, Schaefer K, LaMendola J, Bell GI, Nelson DJ, Steiner DF: Sequence and functional expression in Xenopus oocytes of a human insulinoma and islet potassium channel. Proc Natl Acad Sci U S A. 1991 Jan 1;88(1):53-7. [PubMed:1986382 ]
  2. Philipson LH, Schaefer K, LaMendola J, Bell GI, Steiner DF: Sequence of a human fetal skeletal muscle potassium channel cDNA related to RCK4. Nucleic Acids Res. 1990 Dec 11;18(23):7160. [PubMed:2263489 ]
  3. Tamkun MM, Knoth KM, Walbridge JA, Kroemer H, Roden DM, Glover DM: Molecular cloning and characterization of two voltage-gated K+ channel cDNAs from human ventricle. FASEB J. 1991 Mar 1;5(3):331-7. [PubMed:2001794 ]
  4. Antz C, Geyer M, Fakler B, Schott MK, Guy HR, Frank R, Ruppersberg JP, Kalbitzer HR: NMR structure of inactivation gates from mammalian voltage-dependent potassium channels. Nature. 1997 Jan 16;385(6613):272-5. [PubMed:9000078 ]