Hmdb loader

Showing Protein Hyaluronan and proteoglycan link protein 2 (HMDBP10899)

IdentificationBiological propertiesGene propertiesProtein propertiesExternal linksReferencesXMLShow 1 metabolite
Identification
HMDB Protein ID HMDBP10899
Secondary Accession Numbers
  • 17199
Name Hyaluronan and proteoglycan link protein 2
Synonyms
  1. Brain link protein 1
Gene Name HAPLN2
Protein Type Unknown
Biological Properties
General Function Involved in binding
Specific Function Mediates a firm binding of versican V2 to hyaluronic acid. May play a pivotal role in the formation of the hyaluronan- associated matrix in the central nervous system (CNS) which facilitates neuronal conduction and general structural stabilization. Binds to hyaluronic acid
Pathways Not Available
Reactions Not Available
GO Classification
Function
binding
pattern binding
polysaccharide binding
glycosaminoglycan binding
hyaluronic acid binding
Process
cell adhesion
cellular process
Cellular Location
  1. Secreted
  2. extracellular space
  3. extracellular matrix
Gene Properties
Chromosome Location Chromosome:1
Locus 1q23.1
SNPs HAPLN2
Gene Sequence 
>1023 bp
ATGCCAGGCTGGCTCACCCTCCCCACACTCTGCCGCTTCCTTCTTTGGGCCTTCACCATC
TTCCACAAAGCCCAAGGAGACCCAGCATCCCACCCGGGCCCCCACTACCTCCTGCCCCCC
ATCCACGAGGTCATTCACTCTCATCGTGGGGCCACGGCCACGCTGCCCTGCGTCCTGGGC
ACCACGCCTCCCAGCTACAAGGTGCGCTGGAGCAAGGTGGAGCCTGGGGAGCTCCGGGAA
ACGCTGATCCTCATCACCAACGGACTGCACGCCCGGGGGTATGGGCCCCTGGGAGGGCGC
GCCAGGATGCGGAGGGGGCATCGACTAGACGCCTCCCTGGTCATCGCGGGCGTGCGCCTG
GAGGACGAGGGCCGGTACCGCTGCGAGCTCATCAACGGCATCGAGGACGAGAGCGTGGCG
CTGACCTTGAGCTTGGAGGGTGTGGTGTTTCCGTACCAACCCAGCCGGGGCCGGTACCAG
TTCAATTACTACGAGGCGAAGCAGGCGTGCGAGGAGCAGGACGGACGCCTGGCCACCTAC
TCCCAGCTCTACCAGGCTTGGACCGAGGGTCTGGACTGGTGTAACGCGGGCTGGCTGCTC
GAGGGCTCCGTGCGCTACCCTGTGCTCACCGCACGCGCCCCGTGCGGCGGCCGAGGCCGG
CCCGGGATCCGCAGCTACGGACCCCGCGACCGGATGCGCGACCGCTACGACGCCTTCTGC
TTCACCTCCGCGCTGGCGGGCCAAGTGTTCTTCGTGCCCGGGCGGCTGACGCTGTCTGAA
GCCCACGCGGCGTGCCGGCGACGCGGCGCCGTGGTGGCCAAGGTTGGGCACCTCTACGCC
GCCTGGAAGTTTTCGGGGCTAGACCAGTGCGACGGCGGCTGGCTGGCTGACGGCAGTGTG
CGCTTCCCAATCACCACGCCGAGGCCGCGCTGCGGGGGGCTCCCGGATCCCGGAGTGCGC
AGTTTCGGCTTCCCCAGGCCCCAACAGGCAGCCTATGGGACCTACTGCTACGCCGAGAAT
TAG
Protein Properties
Number of Residues 340
Molecular Weight 37774.7
Theoretical pI 8.95
Pfam Domain Function
Signals
  • 1-26
Transmembrane Regions
  • None
Protein Sequence 
>Hyaluronan and proteoglycan link protein 2
MPGWLTLPTLCRFLLWAFTIFHKAQGDPASHPGPHYLLPPIHEVIHSHRGATATLPCVLG
TTPPSYKVRWSKVEPGELRETLILITNGLHARGYGPLGGRARMRRGHRLDASLVIAGVRL
EDEGRYRCELINGIEDESVALTLSLEGVVFPYQPSRGRYQFNYYEAKQACEEQDGRLATY
SQLYQAWTEGLDWCNAGWLLEGSVRYPVLTARAPCGGRGRPGIRSYGPRDRMRDRYDAFC
FTSALAGQVFFVPGRLTLSEAHAACRRRGAVVAKVGHLYAAWKFSGLDQCDGGWLADGSV
RFPITTPRPRCGGLPDPGVRSFGFPRPQQAAYGTYCYAEN
GenBank ID Protein 11094293
UniProtKB/Swiss-Prot ID Q9GZV7
UniProtKB/Swiss-Prot Entry Name HPLN2_HUMAN
PDB IDs Not Available
GenBank Gene ID AB049054
GeneCard ID HAPLN2
GenAtlas ID HAPLN2
HGNC ID HGNC:17410
References
General References
  1. Gerhard DS, Wagner L, Feingold EA, Shenmen CM, Grouse LH, Schuler G, Klein SL, Old S, Rasooly R, Good P, Guyer M, Peck AM, Derge JG, Lipman D, Collins FS, Jang W, Sherry S, Feolo M, Misquitta L, Lee E, Rotmistrovsky K, Greenhut SF, Schaefer CF, Buetow K, Bonner TI, Haussler D, Kent J, Kiekhaus M, Furey T, Brent M, Prange C, Schreiber K, Shapiro N, Bhat NK, Hopkins RF, Hsie F, Driscoll T, Soares MB, Casavant TL, Scheetz TE, Brown-stein MJ, Usdin TB, Toshiyuki S, Carninci P, Piao Y, Dudekula DB, Ko MS, Kawakami K, Suzuki Y, Sugano S, Gruber CE, Smith MR, Simmons B, Moore T, Waterman R, Johnson SL, Ruan Y, Wei CL, Mathavan S, Gunaratne PH, Wu J, Garcia AM, Hulyk SW, Fuh E, Yuan Y, Sneed A, Kowis C, Hodgson A, Muzny DM, McPherson J, Gibbs RA, Fahey J, Helton E, Ketteman M, Madan A, Rodrigues S, Sanchez A, Whiting M, Madari A, Young AC, Wetherby KD, Granite SJ, Kwong PN, Brinkley CP, Pearson RL, Bouffard GG, Blakesly RW, Green ED, Dickson MC, Rodriguez AC, Grimwood J, Schmutz J, Myers RM, Butterfield YS, Griffith M, Griffith OL, Krzywinski MI, Liao N, Morin R, Palmquist D, Petrescu AS, Skalska U, Smailus DE, Stott JM, Schnerch A, Schein JE, Jones SJ, Holt RA, Baross A, Marra MA, Clifton S, Makowski KA, Bosak S, Malek J: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). Genome Res. 2004 Oct;14(10B):2121-7. [PubMed:15489334 ]
  2. Hirakawa S, Oohashi T, Su WD, Yoshioka H, Murakami T, Arata J, Ninomiya Y: The brain link protein-1 (BRAL1): cDNA cloning, genomic structure, and characterization as a novel link protein expressed in adult brain. Biochem Biophys Res Commun. 2000 Oct 5;276(3):982-9. [PubMed:11027579 ]