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Identification
HMDB Protein ID HMDBP10936
Secondary Accession Numbers
  • 17243
Name Kinase suppressor of Ras 2
Synonyms
  1. hKSR2
Gene Name KSR2
Protein Type Enzyme
Biological Properties
General Function Involved in intracellular signaling pathway
Specific Function Location-regulated scaffold connecting MEK to RAF. Blocks MAP3K8 kinase activity and MAP3K8-mediated signaling. Acts as a negative regulator of MAP3K3-mediated activation of ERK, JNK and NF-kappa-B pathways, inhibiting MAP3K3-mediated interleukin-8 production
Pathways Not Available
Reactions Not Available
GO Classification
Function
binding
catalytic activity
transferase activity
transferase activity, transferring phosphorus-containing groups
kinase activity
nucleoside binding
purine nucleoside binding
adenyl nucleotide binding
adenyl ribonucleotide binding
atp binding
protein kinase activity
protein serine/threonine kinase activity
Process
phosphorus metabolic process
phosphate metabolic process
metabolic process
cellular metabolic process
protein amino acid phosphorylation
intracellular signaling pathway
signaling
signaling pathway
phosphorylation
Cellular Location
  1. Cytoplasm
  2. Peripheral membrane protein
  3. Membrane
Gene Properties
Chromosome Location Chromosome:1
Locus 12q24.22-q24.23
SNPs KSR2
Gene Sequence
>2766 bp
ATGATAGACTTGAGCATCTCCAACCTGGAAGGGCTTAGGACCAAATGTGCTACCTCCAAC
GACCTCACACAAAAAGAAATCCGGACCCTGGAGAGCAAGCTGGTGAAGTACTTCAGCCGG
CAGCTGTCCTGCAAAAAGAAGGTAGCCTTGCAGGAGCGCAACGCGGAGCTGGACGGCTTC
CCCCAGCTACGGCACTGGTTCCGAATCGTCGATGTGCGCAAGGAGGTCCTGGAGGAAATC
TCCCCCGGCCAGCTGAGCCTGGAGGACCTCTTGGAGATGACGGATGAACAGGTGTGCGAG
ACTGTGGAGAAATACGGAGCCAACCGGGAGGAGTGTGCCCGCCTCAACGCCTCCCTCTCC
TGCCTCAGGAATGTCCACATGTCAGGAGGCAACCTTTCCAAACAAGACTGGACCATCCAG
TGGCCCACGACAGAGACGGGGAAGGAGAACAATCCCGTGTGCCCCCCGGAGCCCACCCCG
TGGATCCGCACCCATCTCTCCCAGAGCCCCAGGGTCCCGTCCAAGTGCGTCCAGCACTAT
TGTCACACCAGCCCCACTCCCGGGGCCCCTGTGTACACCCACGTGGACAGGCTTACCGTG
GACGCCTACCCGGGCTTGTGCCCGCCCCCGCCACTGGAGTCGGGCCACCGTTCCCTGCCC
CCATCGCCCCGGCAGCGGCACGCGGTCCGCACCCCGCCGCGCACCCCCAACATCGTCACC
ACCGTGACCCCGCCGGGCACGCCGCCCATGAGGAAGAAGAACAAGCTGAAGCCCCCGGGG
ACCCCACCGCCCTCCTCCCGAAAACTGATACACTTGATCCCGGGATTCACCGCGCTGCAT
CGGAGCAAATCCCACGAGTTCCAGCTGGGGCACCGCGTGGACGAGGCCCACACGCCCAAA
GCCAAGAAGAAGAGCAAACCCTTGAACCTCAAGATCCACAGCAGCGTAGGCAGCTGCGAG
AACATCCCCTCTCAGCAGCGCTCCCCGCTGCTGTCCGAGCGCTCCCTCCGCTCCTTCTTT
GTGGGACACGCACCTTTCCTGCCTTCCACCCCTCCTGTTCACACTGAGGCCAACTTCTCT
GCAAACACACTGTCAGTGCCACGCTGGTCCCCGCAGATCCCTCGCAGAGATCTCGGCAAC
TCCATCAAGCACAGGTTTTCCACCAAGTACTGGATGTCTCAGACGTGCACAGTCTGTGGG
AAAGGGATGCTTTTTGGCCTCAAGTGTAAAAACTGCAAGTTAAAGTGCCACAACAAATGC
ACCAAAGAAGCCCCACCCTGTCATCTTCTGATCATCCACCGAGGAGATCCAGCAAGGTTA
GTCCGGACAGAGTCCGTTCCGTGTGACATCAACAACCCTCTACGGAAGCCACCTCGCTAT
TCAGACCTGCACATCAGTCAGACGCTCCCCAAAACCAACAAAATCAACAAGGACCACATC
CCTGTCCCTTACCAGCCAGACTCCAGCAGCAACCCCTCCTCCACGACGTCCTCCACGCCC
TCCTCGCCAGCACCCCCCCTCCCTCCTAGTGCCACGCCGCCTTCTCCCCTACACCCTTCC
CCACAGTGCACACGGCAGCAGAAGAACTTCAACCTGCCAGCATCCCACTACTACAAATAC
AAGCAGCAGTTCATCTTCCCAGATGTGGTGCCGGTGCCGGAGACGCCGACCCGGGCGCCC
CAGGTCATCCTGCATCCGGTGACCTCGAATCCAATCTTGGAAGGAAATCCATTACTTCAA
ATTGAAGTGGAGCCAACGTCGGAGAATGAAGAGGTCCATGATGAGGCCGAAGAGTCAGAG
GATGACTTCGAGGAGATGAACCTGTCCCTCCTCTCGGCCCGGAGCTTCCCACGCAAGGCC
AGCCAGACCAGCATCTTCCTTCAGGAGTGGGACATCCCCTTTGAGCAGCTGGAGATCGGC
GAGCTCATTGGAAAGGGCCGCTTTGGGCAAGTGTACCACGGCCGCTGGCATGGCGAGGTG
GCCATCCGGCTGATTGACATTGAGAGGGACAACGAGGACCAGCTCAAGGCCTTCAAGCGG
GAGGTGATGGCCTACAGGCAGACACGGCATGAGAACGTGGTGCTTTTCATGGGTGCCTGC
ATGAGCCCGCCTCACCTGGCCATCATCACCAGCCTCTGTAAGGGACGGACGCTCTATTCC
GTTGTGAGGGATGCCAAAATCGTTTTGGATGTCAACAAAACCAGGCAGATTGCTCAAGAA
ATTGTGAAGGGCATGGGCTACCTCCACGCCAAGGGAATCCTACACAAGGACCTCAAGTCA
AAGAACGTCTTCTATGACAACGGCAAAGTGGTCATCACGGACTTTGGACTCTTCAGCATT
TCTGGGGTGCTGCAGGCTGGCAGGCGGGAGGACAAACTGCGCATCCAGAATGGCTGGCTA
TGCCACCTGGCACCAGAGATCATCCGCCAGCTGTCCCCCGACACAGAGGAGGATAAGCTC
CCCTTCTCCAAGCACTCTGACGTCTTTGCCCTTGGCACAATCTGGTATGAACTCCACGCC
AGGGAATGGCCTTTCAAGACCCAACCAGCAGAGGCAATAATCTGGCAAATGGGCACAGGC
ATGAAACCCAACCTCAGCCAGATTGGCATGGGAAAAGAAATCTCGGACATTCTTCTCTTC
TGCTGGGCCTTTGAACAAGAAGAGAGACCTACCTTCACCAAGCTCATGGACATGCTGGAG
AAACTGCCAAAGCGAAACCGTCGCCTGTCTCACCCTGGACATTTCTGGAAGTCTGCAGAG
CTGTGA
Protein Properties
Number of Residues 950
Molecular Weight 107631.4
Theoretical pI 8.87
Pfam Domain Function
Signals
  • None
Transmembrane Regions
  • None
Protein Sequence
>Kinase suppressor of Ras 2
MDEENMTKSEEQQPLSLQKALQQCELVQNMIDLSISNLEGLRTKCATSNDLTQKEIRTLE
SKLVKYFSRQLSCKKKVALQERNAELDGFPQLRHWFRIVDVRKEVLEEISPGQLSLEDLL
EMTDEQVCETVEKYGANREECARLNASLSCLRNVHMSGGNLSKQDWTIQWPTTETGKENN
PVCPPEPTPWIRTHLSQSPRVPSKCVQHYCHTSPTPGAPVYTHVDRLTVDAYPGLCPPPP
LESGHRSLPPSPRQRHAVRTPPRTPNIVTTVTPPGTPPMRKKNKLKPPGTPPPSSRKLIH
LIPGFTALHRSKSHEFQLGHRVDEAHTPKAKKKSKPLNLKIHSSVGSCENIPSQQRSPLL
SERSLRSFFVGHAPFLPSTPPVHTEANFSANTLSVPRWSPQIPRRDLGNSIKHRFSTKYW
MSQTCTVCGKGMLFGLKCKNCKLKCHNKCTKEAPPCHLLIIHRGDPARLVRTESVPCDIN
NPLRKPPRYSDLHISQTLPKTNKINKDHIPVPYQPDSSSNPSSTTSSTPSSPAPPLPPSA
TPPSPLHPSPQCTRQQKNFNLPASHYYKYKQQFIFPDVVPVPETPTRAPQVILHPVTSNP
ILEGNPLLQIEVEPTSENEEVHDEAEESEDDFEEMNLSLLSARSFPRKASQTSIFLQEWD
IPFEQLEIGELIGKGRFGQVYHGRWHGEVAIRLIDIERDNEDQLKAFKREVMAYRQTRHE
NVVLFMGACMSPPHLAIITSLCKGRTLYSVVRDAKIVLDVNKTRQIAQEIVKGMGYLHAK
GILHKDLKSKNVFYDNGKVVITDFGLFSISGVLQAGRREDKLRIQNGWLCHLAPEIIRQL
SPDTEEDKLPFSKHSDVFALGTIWYELHAREWPFKTQPAEAIIWQMGTGMKPNLSQIGMG
KEISDILLFCWAFEQEERPTFTKLMDMLEKLPKRNRRLSHPGHFWKSAEL
GenBank ID Protein 167621456
UniProtKB/Swiss-Prot ID Q6VAB6
UniProtKB/Swiss-Prot Entry Name KSR2_HUMAN
PDB IDs Not Available
GenBank Gene ID Not Available
GeneCard ID KSR2
GenAtlas ID KSR2
HGNC ID HGNC:18610
References
General References
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