Hmdb loader
Identification
HMDB Protein ID HMDBP11004
Secondary Accession Numbers
  • 17328
Name Long-chain-fatty-acid--CoA ligase ACSBG2
Synonyms
  1. Acyl-CoA synthetase bubblegum family member 2
  2. Bubblegum-related protein
  3. PRTD-NY3
Gene Name ACSBG2
Protein Type Enzyme
Biological Properties
General Function Involved in catalytic activity
Specific Function Mediates activation of long-chain fatty acids for both synthesis of cellular lipids, and degradation via beta-oxidation. Able to activate long-chain fatty acids. Also able to activate very long-chain fatty acids; however, the relevance of such activity is unclear in vivo. Has increased ability to activate oleic and linoleic acid. May play a role in spermatogenesis.
Pathways
  • Adipocytokine signaling pathway
  • fatty acid metabolism
  • PPAR signaling pathway
Reactions
Adenosine triphosphate + a long-chain fatty acid + Coenzyme A → Adenosine monophosphate + Pyrophosphate + an acyl-CoA details
Adenosine triphosphate + Palmitic acid + Coenzyme A → Adenosine monophosphate + Palmityl-CoA + Pyrophosphate details
GO Classification
Biological Process
multicellular organismal development
spermatogenesis
cell differentiation
Cellular Component
mitochondrion
membrane
Function
catalytic activity
Molecular Function
acyl-CoA hydrolase activity
ATP binding
long-chain fatty acid-CoA ligase activity
Process
metabolic process
Cellular Location
  1. Cytoplasm
  2. Peripheral membrane protein
  3. Membrane
Gene Properties
Chromosome Location 19
Locus 19p13.3
SNPs ACSBG2
Gene Sequence
>2001 bp
ATGACTGGAACCCCAAAGACTCAAGAAGGAGCTAAAGATCTTGAAGTAGACATGAATAAA
ACAGAAGTTACTCCCAGGCTGTGGACCACCTGTCGAGATGGAGAAGTCCTTCTGAGGCTA
TCCAAACACGGACCAGGCCATGAGACCCCGATGACCATCCCTGAATTTTTTCGAGAGTCA
GTCAACCGATTTGGAACTTATCCAGCCCTCGCATCCAAGAATGGCAAAAAGTGGGAAATT
CTGAATTTCAACCAGTACTATGAGGCTTGTCGGAAGGCTGCAAAATCCTTGATCAAGCTG
GGTTTGGAGCGTTTCCACGGAGTTGGTATCCTGGGGTTTAACTCTGCAGAGTGGTTTATC
ACTGCTGTTGGTGCCATCCTAGCCGGGGGTCTTTGTGTTGGTATTTATGCCACCAACTCT
GCCGAGGCTTGTCAATATGTCATCACTCATGCCAAAGTGAACATCTTGCTGGTTGAGAAT
GATCAACAGTTACAGAAAATCCTTTCGATTCCACAGAGCAGCCTAGAGCCCCTAAAAGCG
ATCATCCAGTACAGACTGCCAATGAAGAAGAACAACAACTTGTACTCTTGGGATGATTTC
ATGGAACTTGGCAGAAGTATCCCTGACACCCAACTGGAGCAGGTCATCGAGAGCCAGAAG
GCGAATCAATGCGCAGTGCTCATCTACACTTCAGGGACCACAGGCATACCCAAGGGAGTG
ATGCTCAGTCATGACAACATCACGTGGATTGCAGGAGCAGTGACAAAGGACTTTAAACTG
ACAGACAAGCATGAGACGGTGGTTAGCTACCTCCCACTCAGCCATATTGCAGCACAGATG
ATGGACATCTGGGTACCCATAAAGATTGGGGCGCTCACATACTTTGCTCAAGCAGATGCT
CTCAAGGGCACCTTGGTAAGTACTCTAAAGGAGGTAAAACCTACTGTCTTCATTGGAGTG
CCTCAAATTTGGGAGAAGATACATGAGATGGTGAAGAAAAATAGTGCCAAGTCCATGGGC
TTGAAGAAGAAGGCATTCGTGTGGGCAAGAAACATTGGCTTCAAGGTCAACTCAAAAAAG
ATGTTGGGGAAATATAATACTCCCGTGAGCTACCGCATGGCTAAGACTCTCGTGTTCAGC
AAAGTCAAGACATCCCTTGGCTTGGATCACTGTCACTCTTTTATCAGTGGGACTGCGCCC
CTCAACCAAGAGACTGCCGAGTTCTTTCTAAGCTTGGACATACCTATAGGCGAGTTGTAT
GGGTTGAGTGAGAGCTCGGGACCCCACACGATATCCAACCAGAATAACTACAGGCTTCTA
AGCTGTGGCAAGATCTTGACTGGGTGTAAGAATATGCTGTTCCAGCAGAACAAGGATGGC
ATTGGGGAGATCTGCCTCTGGGGTAGGCACATCTTCATGGGCTATCTGGAAAGTGAGACT
GAAACTACAGAGGCCATCGATGATGAAGGCTGGCTACACTCTGGGGATCTGGGCCAGCTG
GACGGTCTGGGTTTCCTCTATGTCACCGGCCACATCAAAGAAATCCTTATCACTGCTGGT
GGTGAAAATGTGCCCCCCATTCCTGTTGAGACCTTGGTTAAGAAGAAGATCCCCATCATC
AGTAACGCCATGTTAGTAGGAGATAAACTGAAGTTTCTGAGCATGTTGCTGACGCTGAAG
TGTGAGATGAATCAGATGAGCGGAGAACCTCTGGACAAGCTGAACTTCGAGGCCATCAAC
TTCTGTCGGGGTCTGGGCAGCCAGGCATCCACCGTGACTGAGATGGTGAAGCAGCAAGAC
CCCCTGGTCTACAAGGCCATCCAGCAAGGCATCAATGCTGTGAACCAGGAAGCCATGAAC
AATGCACAGAGGATTGAAAAGTGGGTCATCTTGGAGAAGGACTTTTCCATCTATGGTGGA
GAGCTAGGTCCAATGATGAAACTTAAGAGACATTTTGTAGCCCAGAAATACAAAAAACAA
ATTGATCACATGTACCACTGA
Protein Properties
Number of Residues 666
Molecular Weight 74353.835
Theoretical pI 8.461
Pfam Domain Function
Signals Not Available
Transmembrane Regions Not Available
Protein Sequence
>Long-chain-fatty-acid--CoA ligase ACSBG2
MTGTPKTQEGAKDLEVDMNKTEVTPRLWTTCRDGEVLLRLSKHGPGHETPMTIPEFFRES
VNRFGTYPALASKNGKKWEILNFNQYYEACRKAAKSLIKLGLERFHGVGILGFNSAEWFI
TAVGAILAGGLCVGIYATNSAEVCQYVITHAKVNILLVENDQQLQKILSIPQSSLEPLKA
IIQYRLPMKKNNNLYSWDDFMELGRSIPDTQLEQVIESQKANQCAVLIYTSGTTGIPKGV
MLSHDNITWIAGAVTKDFKLTDKHETVVSYLPLSHIAAQMMDIWVPIKIGALTYFAQADA
LKGTLVSTLKEVKPTVFIGVPQIWEKIHEMVKKNSAKSMGLKKKAFVWARNIGFKVNSKK
MLGKYNTPVSYRMAKTLVFSKVKTSLGLDHCHSFISGTAPLNQETAEFFLSLDIPIGELY
GLSESSGPHTISNQNNYRLLSCGKILTGCKNMLFQQNKDGIGEICLWGRHIFMGYLESET
ETTEAIDDEGWLHSGDLGQLDGLGFLYVTGHIKEILITAGGENVPPIPVETLVKKKIPII
SNAMLVGDKLKFLSMLLTLKCEMNQMSGEPLDKLNFEAINFCRGLGSQASTVTEIVKQQD
PLVYKAIQQGINAVNQEAMNNAQRIEKWVILEKDFSIYGGELGPMMKLKRHFVAQKYKKQ
IDHMYH
GenBank ID Protein 32968194
UniProtKB/Swiss-Prot ID Q5FVE4
UniProtKB/Swiss-Prot Entry Name ACBG2_HUMAN
PDB IDs Not Available
GenBank Gene ID AJ577571
GeneCard ID ACSBG2
GenAtlas ID ACSBG2
HGNC ID HGNC:24174
References
General References
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