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Identification
HMDB Protein ID HMDBP11437
Secondary Accession Numbers
  • 17780
Name Elongation of very long chain fatty acids protein 2
Synonyms
  1. 3-keto acyl-CoA synthase ELOVL2
  2. ELOVL fatty acid elongase 2
  3. Very-long-chain 3-oxoacyl-CoA synthase 2
  4. ELOVL FA elongase 2
Gene Name ELOVL2
Protein Type Unknown
Biological Properties
General Function Involved in fatty acid biosynthetic process
Specific Function Condensing enzyme that catalyzes the synthesis of polyunsaturated very long chain fatty acid (C20- and C22-PUFA). Acts specifically toward polyunsaturated acyl-CoA with the higher activity toward C20:4(n-6) acyl-CoA.
Pathways
  • Biosynthesis of unsaturated fatty acids
  • Fatty acid elongation
Reactions
A very-long-chain acyl-CoA + Malonyl-CoA → Coenzyme A + a very-long-chain 3-oxoacyl-CoA + CO(2) details
Malonyl-CoA + Acyl-CoA → 3-Oxoacyl-CoA + Coenzyme A + Carbon dioxide details
GO Classification
Biological Process
very long-chain fatty acid biosynthetic process
fatty acid elongation, polyunsaturated fatty acid
alpha-linolenic acid metabolic process
linoleic acid metabolic process
long-chain fatty-acyl-CoA biosynthetic process
triglyceride biosynthetic process
Cellular Component
endoplasmic reticulum membrane
integral to membrane
Component
cell part
membrane part
intrinsic to membrane
integral to membrane
Molecular Function
fatty acid elongase activity
Cellular Location
  1. Multi-pass membrane protein (Potential)
  2. Endoplasmic reticulum membrane
Gene Properties
Chromosome Location 6
Locus 6p24.2
SNPs ELOVL2
Gene Sequence
>891 bp
ATGGAACATCTAAAGGCCTTTGATGATGAAATCAATGCTTTTTTGGACAATATGTTTGGA
CCGCGAGATTCTCGAGTCAGAGGGTGGTTCACGTTGGACTCTTACCTTCCTACCTTTTTT
CTTACTGTCATGTATCTGCTCTCAATATGGCTGGGTAACAAGTATATGAAGAACAGACCT
GCTCTTTCTCTCAGGGGTATCCTCACCTTGTATAATCTTGGAATCACACTTCTCTCCGCG
TACATGCTGGCAGAGCTCATTCTCTCCACTTGGGAAGGAGGCTACAACTTACAGTGTCAA
GATCTTACCAGCGCAGGGGAAGCTGACATCCGGGTAGCCAAGGTGCTTTGGTGGTACTAT
TTCTCCAAATCAGTAGAGTTCCTGGACACAATTTTCTTCGTTTTGCGGAAAAAAACGAGT
CAGATTACTTTTCTTCATGTATATCATCATGCTTCTATGTTTAACATCTGGTGGTGTGTC
TTGAACTGGATACCTTGTGGACAAAGTTTCTTTGGACCAACACTGAACAGTTTTGTCCAC
ATTCTTATGTACTCCTACTATGGACTTTCTGTGTTTCCATCTATGCACAAGTATCTTTGG
TGGAAGAAATATCTCACACAGGCTCAGCTGGTGCAGTTCGTGCTCACCATCACGCACACC
ATGAGCGCCGTCGTGAAACCGTGTGGCTTCCCCTTCGGTTGTCTCATCTTCCAGTCATCT
TATATGCTAACGTTAGTCATCCTCTTCTTAAATTTTTATGTTCAGACATACCGAAAAAAG
CCAATGAAGAAAGATATGCAAGAGCCACCTGCAGGGAAAGAAGTGAAGAATGGTTTTTCC
AAAGCCTACTTCACTGCAGCAAATGGAGTGATGAACAAGAAAGCACAATAA
Protein Properties
Number of Residues 296
Molecular Weight 34584.435
Theoretical pI 9.255
Pfam Domain Function
Signals Not Available
Transmembrane Regions Not Available
Protein Sequence
>Elongation of very long chain fatty acids protein 2
MEHLKAFDDEINAFLDNMFGPRDSRVRGWFMLDSYLPTFFLTVMYLLSIWLGNKYMKNRP
ALSLRGILTLYNLGITLLSAYMLAELILSTWEGGYNLQCQDLTSAGEADIRVAKVLWWYY
FSKSVEFLDTIFFVLRKKTSQITFLHVYHHASMFNIWWCVLNWIPCGQSFFGPTLNSFIH
ILMYSYYGLSVFPSMHKYLWWKKYLTQAQLVQFVLTITHTMSAVVKPCGFPFGCLIFQSS
YMLTLVILFLNFYVQTYRKKPMKKDMQEPPAGKEVKNGFSKAYFTAANGVMNKKAQ
GenBank ID Protein 7020361
UniProtKB/Swiss-Prot ID Q9NXB9
UniProtKB/Swiss-Prot Entry Name ELOV2_HUMAN
PDB IDs Not Available
GenBank Gene ID AK000341
GeneCard ID ELOVL2
GenAtlas ID ELOVL2
HGNC ID HGNC:14416
References
General References
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