Hmdb loader
Identification
HMDB Protein ID HMDBP11438
Secondary Accession Numbers
  • 17781
Name Elongation of very long chain fatty acids protein 1
Synonyms
  1. 3-keto acyl-CoA synthase ELOVL1
  2. ELOVL fatty acid elongase 1
  3. Very-long-chain 3-oxoacyl-CoA synthase 1
  4. ELOVL FA elongase 1
Gene Name ELOVL1
Protein Type Unknown
Biological Properties
General Function Involved in protein binding
Specific Function Condensing enzyme that catalyzes the synthesis of both saturated and monounsaturated very long chain fatty acids. Exhibits activity toward saturated C18 to C26 acyl-CoA substrates, with the highest activity towards C22:0 acyl-CoA. Important for saturated C24:0 and monounsaturated C24:1 sphingolipid synthesis.
Pathways
  • Fatty acid elongation
Reactions
A very-long-chain acyl-CoA + Malonyl-CoA → Coenzyme A + a very-long-chain 3-oxoacyl-CoA + CO(2) details
Malonyl-CoA + Acyl-CoA → 3-Oxoacyl-CoA + Coenzyme A + Carbon dioxide details
GO Classification
Biological Process
fatty acid elongation, monounsaturated fatty acid
fatty acid elongation, saturated fatty acid
very long-chain fatty acid biosynthetic process
sphingolipid biosynthetic process
long-chain fatty-acyl-CoA biosynthetic process
triglyceride biosynthetic process
Cellular Component
integral to endoplasmic reticulum membrane
Component
cell part
membrane part
intrinsic to membrane
integral to membrane
Molecular Function
fatty acid elongase activity
Cellular Location
  1. Multi-pass membrane protein (Potential)
  2. Endoplasmic reticulum membrane
Gene Properties
Chromosome Location 1
Locus 1p34.2
SNPs ELOVL1
Gene Sequence
>840 bp
ATGGAGGCTGTTGTGAACTTGTACCAAGAGGTGATGAAGCACGCAGATCCCCGGATCCAG
GGCTACCCTCTGATGGGGTCCCCCTTGCTAATGACCTCCATTCTCCTGACCTACGTGTAC
TTCGTTCTCTCACTTGGGCCTCGCATCATGGCTAATCGGAAGCCCTTCCAGCTCCGTGGC
TTCATGATTGTCTACAACTTCTCACTGGTGGCACTCTCCCTCTACATTGTCTATGAGTTC
CTGATGTCGGGCTGGCTGAGCACCTATACCTGGCGCTGTGACCCTGTGGACTATTCCAAC
AGCCCTGAGGCACTTAGGATGGTTCGGGTGGCCTGGCTCTTCCTCTTCTCCAAGTTCATT
GAGCTGATGGACACAGTGATCTTTATTCTCCGAAAGAAAGACGGGCAGGTGACCTTCCTA
CATGTCTTCCATCACTCTGTGCTTCCCTGGAGCTGGTGGTGGGGGGTAAAGATTGCCCCG
GGAGGAATGGGCTCTTTCCATGCCATGATAAACTCTTCCGTGCATGTCATAATGTACCTG
TACTACGGATTATCTGCCTTTGGCCCTGTGGCACAACCCTACCTTTGGTGGAAAAAGCAC
ATGACAGCCATTCAGCTGATCCAGTTTGTCCTGGTCTCACTGCACATCTCCCAGTACTAC
TTTATGTCCAGCTGTAACTACCAGTACCCAGTCATTATTCACCTCATCTGGATGTATGGC
ACCATCTTCTTCATGCTGTTCTCCAACTTCTGGTATCACTCTTATACCAAGGGCAAGCGG
CTGCCCCGTGCACTTCAGCAAAATGGAGCTCCAGGTATTGCCAAGGTCAAGGCCAACTGA
Protein Properties
Number of Residues 279
Molecular Weight 32662.49
Theoretical pI 9.602
Pfam Domain Function
Signals Not Available
Transmembrane Regions Not Available
Protein Sequence
>Elongation of very long chain fatty acids protein 1
MEAVVNLYQEVMKHADPRIQGYPLMGSPLLMTSILLTYVYFVLSLGPRIMANRKPFQLRG
FMIVYNFSLVALSLYIVYEFLMSGWLSTYTWRCDPVDYSNSPEALRMVRVAWLFLFSKFI
ELMDTVIFILRKKDGQVTFLHVFHHSVLPWSWWWGVKIAPGGMGSFHAMINSSVHVIMYL
YYGLSAFGPVAQPYLWWKKHMTAIQLIQFVLVSLHISQYYFMSSCNYQYPVIIHLIWMYG
TIFFMLFSNFWYHSYTKGKRLPRALQQNGAPGIAKVKAN
GenBank ID Protein 13489093
UniProtKB/Swiss-Prot ID Q9BW60
UniProtKB/Swiss-Prot Entry Name ELOV1_HUMAN
PDB IDs Not Available
GenBank Gene ID NM_022821.2
GeneCard ID ELOVL1
GenAtlas ID ELOVL1
HGNC ID HGNC:14418
References
General References
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