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Showing Protein Abl interactor 1 (HMDBP11450)

IdentificationBiological propertiesGene propertiesProtein propertiesExternal linksReferencesXMLShow 3 metabolites
Identification
HMDB Protein ID HMDBP11450
Secondary Accession Numbers
  • 17795
Name Abl interactor 1
Synonyms
  1. Abelson interactor 1
  2. Abi-1
  3. Abl-binding protein 4
  4. AblBP4
  5. Eps8 SH3 domain-binding protein
  6. Eps8-binding protein
  7. Nap1-binding protein
  8. Nap1BP
  9. Spectrin SH3 domain-binding protein 1
  10. e3B1
Gene Name ABI1
Protein Type Unknown
Biological Properties
General Function Transcription
Specific Function May act in negative regulation of cell growth and transformation by interacting with nonreceptor tyrosine kinases ABL1 and/or ABL2. May play a role in regulation of EGF-induced Erk pathway activation. Involved in cytoskeletal reorganization and EGFR signaling. Together with EPS8 participates in transduction of signals from Ras to Rac. In vitro, a trimeric complex of ABI1, EPS8 and SOS1 exhibits Rac specific guanine nucleotide exchange factor (GEF) activity and ABI1 seems to act as an adapter in the complex. Regulates ABL1/c-Abl-mediated phosphorylation of MENA. Recruits WASF1 to lamellipodia and there seems to regulate WASF1 protein level
Pathways Not Available
Reactions Not Available
GO Classification
Component
cell part
intracellular part
cytoplasm
Cellular Location
  1. Nucleus
  2. Cytoplasm
  3. Cytoplasm
  4. cytoskeleton
  5. Cell junction
  6. synapse
  7. Cell projection
  8. Cell projection
  9. Cell projection
  10. lamellipodium
  11. growth cone
  12. synaptosome
  13. filopodium
Gene Properties
Chromosome Location Chromosome:1
Locus 10p11.2
SNPs ABI1
Gene Sequence 
>1527 bp
ATGGCAGAGCTGCAGATGTTACTAGAGGAGGAGATCCCGTCTGGCAAGAGGGCGCTGATC
GAGAGTTACCAGAACCTGACTCGGGTGGCAGACTACTGTGAAAACAACTACATACAGGCT
ACAGACAAGAGAAAAGCTTTAGAGGAGACCAAAGCCTATACAACCCAATCTCTAGCTAGT
GTTGCTTATCAAATAAATGCATTGGCCAACAATGTACTCCAGTTGCTGGATATCCAAGCC
TCTCAGCTTCGGAGAATGGAGTCTTCCATCAATCATATCTCACAGACTGTGGATATTCAT
AAGGAGAAAGTGGCACGAAGAGAGATTGGTATTTTGACAACAAATAAGAATACATCAAGA
ACTCACAAAATAATAGCACCTGCGAATATGGAGCGCCCTGTAAGGTATATTCGGAAACCT
ATCGATTACACAGTTCTGGATGATGTGGGCCATGGTGTCAAGTGGCTAAAAGCCAAGCAT
GGAAATAACCAGCCTGCAAGAACTGGCACACTGTCGAGAACAAATCCTCCTACTCAGAAA
CCGCCAAGTCCTCCCATGTCAGGCCGGGGAACACTGGGACGGAATACTCCTTATAAAACC
CTGGAACCTGTTAAACCCCCAACAGTTCCTAATGACTATATGACCAGTCCTGCTAGGCTT
GGAAGTCAGCATAGTCCAGGCAGGACAGCATCTTTAAATCAGAGACCAAGGACACACAGT
GGAAGTAGTGGAGGAAGTGGAAGTCGAGAAAACAGTGGTAGCAGTAGTATTGGCATTCCC
ATTGCTGTGCCTACACCTTCGCCACCCACTATTGGACCAGAAAACATTTCTGTCCCTCCT
CCTTCTGGAGCTCCACCAGCACCACCTCTGGCACCACTTCTCCCAGTGAGCACTGTGATA
GCAGCCCCGGGCTCAGCTCCTGGTTCCCAGTATGGCACAATGACCAGGCAGATATCTCGA
CACAACTCTACTACTTCTTCGACATCTTCTGGTGGATACAGACGAACTCCCTCTGTGACT
GCTCAATTTTCTGCTCAGCCTCATGTTAATGGAGGTCCACTTTATTCTCAAAATTCAATT
TCTATTGCTCCACCCCCTCCCCCTATGCCTCAGTTGACTCCACAGATACCTCTCACAGGC
TTCGTGGCCAGGGTGCAGGAAAACATTGCTGATAGTCCAACTCCACCGCCACCACCTCCA
CCAGATGACATTCCCATGTTTGATGACTCTCCACCTCCCCCACCACCACCACCAGTGGAT
TATGAAGATGAGGAGGCTGCAGTAGTTCAGTATAATGATCCATATGCAGATGGGGATCCT
GCTTGGGCCCCCAAGAATTATATTGAGAAAGTTGTTGCAATATATGATTATACAAAAGAC
AAGGATGATGAGCTGTCATTTATGGAGGGTGCAATCATTTATGTTATAAAGAAGAATGAT
GATGGCTGGTATGAAGGAGTCTGCAATCGAGTGACTGGTCTGTTCCCTGGGAACTATGTT
GAATCAATCATGCACTATACTGATTAA
Protein Properties
Number of Residues 508
Molecular Weight 55080.4
Theoretical pI 7.08
Pfam Domain Function
Signals
  • None
Transmembrane Regions
  • None
Protein Sequence 
>Abl interactor 1
MAELQMLLEEEIPSGKRALIESYQNLTRVADYCENNYIQATDKRKALEETKAYTTQSLAS
VAYQINALANNVLQLLDIQASQLRRMESSINHISQTVDIHKEKVARREIGILTTNKNTSR
THKIIAPANMERPVRYIRKPIDYTVLDDVGHGVKWLKAKHGNNQPARTGTLSRTNPPTQK
PPSPPMSGRGTLGRNTPYKTLEPVKPPTVPNDYMTSPARLGSQHSPGRTASLNQRPRTHS
GSSGGSGSRENSGSSSIGIPIAVPTPSPPTIGPENISVPPPSGAPPAPPLAPLLPVSTVI
AAPGSAPGSQYGTMTRQISRHNSTTSSTSSGGYRRTPSVTAQFSAQPHVNGGPLYSQNSI
SIAPPPPPMPQLTPQIPLTGFVARVQENIADSPTPPPPPPPDDIPMFDDSPPPPPPPPVD
YEDEEAAVVQYNDPYADGDPAWAPKNYIEKVVAIYDYTKDKDDELSFMEGAIIYVIKKND
DGWYEGVCNRVTGLFPGNYVESIMHYTD
GenBank ID Protein 61743942
UniProtKB/Swiss-Prot ID Q8IZP0
UniProtKB/Swiss-Prot Entry Name ABI1_HUMAN
PDB IDs Not Available
GenBank Gene ID NM_005470.3
GeneCard ID ABI1
GenAtlas ID ABI1
HGNC ID HGNC:11320
References
General References
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  10. Gevaert K, Goethals M, Martens L, Van Damme J, Staes A, Thomas GR, Vandekerckhove J: Exploring proteomes and analyzing protein processing by mass spectrometric identification of sorted N-terminal peptides. Nat Biotechnol. 2003 May;21(5):566-9. Epub 2003 Mar 31. [PubMed:12665801 ]
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  14. Taki T, Shibuya N, Taniwaki M, Hanada R, Morishita K, Bessho F, Yanagisawa M, Hayashi Y: ABI-1, a human homolog to mouse Abl-interactor 1, fuses the MLL gene in acute myeloid leukemia with t(10;11)(p11.2;q23). Blood. 1998 Aug 15;92(4):1125-30. [PubMed:9694699 ]
  15. Biesova Z, Piccoli C, Wong WT: Isolation and characterization of e3B1, an eps8 binding protein that regulates cell growth. Oncogene. 1997 Jan 16;14(2):233-41. [PubMed:9010225 ]
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  17. Yamamoto A, Suzuki T, Sakaki Y: Isolation of hNap1BP which interacts with human Nap1 (NCKAP1) whose expression is down-regulated in Alzheimer's disease. Gene. 2001 Jun 27;271(2):159-69. [PubMed:11418237 ]
  18. Gu Y, Souza RF, Wu RF, Xu YC, Terada LS: Induction of colonic epithelial cell apoptosis by p47-dependent oxidants. FEBS Lett. 2003 Apr 10;540(1-3):195-200. [PubMed:12681507 ]
  19. Fan PD, Goff SP: Abl interactor 1 binds to sos and inhibits epidermal growth factor- and v-Abl-induced activation of extracellular signal-regulated kinases. Mol Cell Biol. 2000 Oct;20(20):7591-601. [PubMed:11003655 ]