Hmdb loader
Identification
HMDB Protein ID HMDBP11463
Secondary Accession Numbers
  • 17811
Name Pleckstrin homology domain-containing family G member 6
Synonyms
  1. MyoGEF
  2. Myosin-interacting guanine nucleotide exchange factor
  3. PH domain-containing family G member 6
Gene Name PLEKHG6
Protein Type Unknown
Biological Properties
General Function Involved in Rho guanyl-nucleotide exchange factor activity
Specific Function Guanine nucleotide exchange factor activating the small GTPase RHOA, which, in turn, induces myosin filament formation. Also activates RHOG. Does not activate RAC1, or to a much lower extent than RHOA and RHOG. Part of a functional unit, involving PLEKHG6, MYH10 and RHOA, at the cleavage furrow to advance furrow ingression during cytokinesis. In epithelial cells, required for the formation of microvilli and membrane ruffles on the apical pole. Along with EZR, required for normal macropinocytosis
Pathways Not Available
Reactions Not Available
GO Classification
Component
cell part
intracellular
Function
small gtpase regulator activity
ras guanyl-nucleotide exchange factor activity
rho guanyl-nucleotide exchange factor activity
enzyme regulator activity
nucleoside-triphosphatase regulator activity
gtpase regulator activity
Process
regulation of ras protein signal transduction
regulation of rho protein signal transduction
biological regulation
regulation of biological process
regulation of cellular process
regulation of cell communication
regulation of signal transduction
regulation of small gtpase mediated signal transduction
Cellular Location
  1. Cytoplasm
  2. Cytoplasm
  3. Cytoplasm
  4. cytoskeleton
  5. cytoskeleton
  6. spindle
  7. spindle pole
  8. Cleavage furrow
Gene Properties
Chromosome Location Chromosome:1
Locus 12p13.31
SNPs PLEKHG6
Gene Sequence
>2373 bp
ATGAAGGCCTTTGGTCCTCCACATGAGGGCCCCCTCCAAGGACTCGTGGCCTCCCGCATT
GAGACTTATGGGGGCCGGCATCGAGCCTCTGCTCAGAGCACTGCTGGCAGACTCTATCCC
CGAGGATACCCTGTGCTGGATCCCAGTCGCCGACGCCTCCAGCAGTATGTCCCCTTTGCC
AGGGGTTCTGGCCAGGCCCGAGGCCTGTCACCCATGAGACTGCGAGATCCAGAGCCCGAG
AAGAGGCACGGGGGCCATGTGGGGGCTGGCCTGCTTCACTCCCCCAAACTCAAGGAACTC
ACCAAGGCCCATGAGCTGGAGGTGAGGCTGCACACTTTCAGCATGTTTGGGATGCCCCGG
CTGCCCCCTGAGGACCGGCGGCACTGGGAGATAGGAGAGGGTGGCGACAGTGGCCTGACC
ATCGAGAAGTCCTGGAGGGAGCTGGTGCCTGGGCACAAGGAGATGAGCCAGGAGCTCTGC
CACCAACAGGAGGCCCTGTGGGAGCTCCTGACCACCGAGCTGATCTACGTGAGAAAGCTC
AAGATCATGACTGATCTGCTAGCCGCCGGCCTGCTGAACCTGCAGCGAGTGGGACTGCTG
ATGGAAGTGTCAGCTGAGACCCTGTTTGGAAATGTCCCCAGCCTGATTCGAACCCACCGG
AGCTTTTGGGATGAGGTGCTGGGGCCCACCCTGGAGGAGACTCGGGCCTCGGGCCAGCCT
CTGGACCCCATTGGTCTGCAAAGTGGCTTCCTGACGTTTGGCCAGCGGTTCCACCCCTAT
GTCCAGTACTGCCTCCGAGTGAAGCAGACCATGGCTTACGCCCGAGAACAGCAAGAAACT
AACCCTCTCTTCCATGCCTTCGTGCAGTGGTGTGAGAAGCACAAGCGCTCTGGGAGGCAG
ATGCTCTGTGACTTGCTTATCAAGCCCCACCAGCGCATCACCAAGTACCCACTGCTGCTC
CATGCTGTGCTCAAGAGGAGCCCCGAGGCACGAGCCCAAGAGGCCCTGAATGCCATGATT
GAAGCCGTGGAGTCATTCCTGCGACACATCAATGGGCAGGTCCGCCAGGGCGAAGAGCAA
GAGAGCTTGGCGGCTGCAGCACAACGCATCGGGCCCTACGAGGTGCTGGAGCCACCCAGT
GATGAGGTGGAGAAGAACCTGCGCCCATTCTCCACCCTGGACCTGACGTCCCCCATGCTG
GGGGTTGCATCTGAGCACACCAGACAGCTGCTGCTGGAGGGGCCTGTGCGAGTGAAGGAG
GGACGAGAAGGGAAGCTGGACGTGTACCTGTTCCTCTTCTCTGATGTGCTCCTTGTGACC
AAGCCCCAGCGCAAGGCGGACAAAGCCAAGGTCATCCGACCCCCTCTCATGCTGGAGAAG
CTCGTGTGCCAACCCCTGCGAGACCCCAACAGCTTCCTGCTGATCCACCTCACTGAATTC
CAGTGTGTCTCCAGCGCCCTCCTTGTGCACTGTCCCAGTCCTACAGACCGTGCCCAGTGG
CTGGAGAAGACCCAGCAGGCCCAGGCCGCCCTACAGAAGCTGAAGGCAGAGGAGTATGTT
CAACAGAAGAGGGAGCTCCTGACCCTCTATCGGGACCAGGACAGGGAGTCCCCCAGCACC
AGGCCCTCCACGCCTTCCCTGGAGGGCTCTCAGAGCAGCGCAGAGGGGAGGACTCCTGAG
TTCTCGACCATTATCCCCCACCTGGTGGTGACAGAAGACACAGATGAAGATGCTCCCCTT
GTGCCAGATGATACCTCAGACTCTGGCTACGGCACTTTGATCCCAGGCACCCCCACGGGG
TCCCGCTCCCCACTGAGCCGTCTACGCCAAAGAGCCCTTCGGCGGGACCCTCGCCTCACC
TTCTCCACCCTGGAACTCCGGGACATCCCTCTGCGTCCCCACCCTCCCGACCCCCAAGCT
CCTCAACGCCGAAGCGCCCCCGAACTGCCGGAAGGAATCCTAAAAGGAGGCAGTCTTCCC
CAGGAAGACCCACCAACCTGGTCTGAGGAAGAAGATGGGGCCTCCGAGCGAGGGAATGTG
GTGGTGGAAACACTCCACAGGGCCCGGCTTCGGGGCCAGCTTCCCTCCTCCCCAACCCAT
GCTGACTCTGCCGGGGAAAGCCCCTGGGAGTCCTCAGGGGAGGAGGAAGAAGAGGGGCCT
CTGTTCCTGAAAGCTGGCCACACATCCCTGCGCCCAATGCGGGCTGAGGACATGCTCAGA
GAGATCCGGGAGGAGCTGGCCAGCCAAAGGATTGAGGGGGCCGAGGAGCCCCGGGACAGC
AGGCCACGGAAGCTGACTCGGGCCCAGCTGCAGAGGATGCGGGGGCCCCACATCATTCAG
CTGGACACCCCTCTGTCCGCATCAGAGGTATGA
Protein Properties
Number of Residues 790
Molecular Weight 88960.3
Theoretical pI 7.01
Pfam Domain Function
Signals
  • None
Transmembrane Regions
  • None
Protein Sequence
>Pleckstrin homology domain-containing family G member 6
MKAFGPPHEGPLQGLVASRIETYGGRHRASAQSTAGRLYPRGYPVLDPSRRRLQQYVPFA
RGSGQARGLSPMRLRDPEPEKRHGGHVGAGLLHSPKLKELTKAHELEVRLHTFSMFGMPR
LPPEDRRHWEIGEGGDSGLTIEKSWRELVPGHKEMSQELCHQQEALWELLTTELIYVRKL
KIMTDLLAAGLLNLQRVGLLMEVSAETLFGNVPSLIRTHRSFWDEVLGPTLEETRASGQP
LDPIGLQSGFLTFGQRFHPYVQYCLRVKQTMAYAREQQETNPLFHAFVQWCEKHKRSGRQ
MLCDLLIKPHQRITKYPLLLHAVLKRSPEARAQEALNAMIEAVESFLRHINGQVRQGEEQ
ESLAAAAQRIGPYEVLEPPSDEVEKNLRPFSTLDLTSPMLGVASEHTRQLLLEGPVRVKE
GREGKLDVYLFLFSDVLLVTKPQRKADKAKVIRPPLMLEKLVCQPLRDPDSFLLIHLTEF
QCVSSALLVHCPSPTDRAQWLEKTQQAQAALQKLKAEEYVQQKRELLTLYRDQDRESPST
RPSTPSLEGSQSSAEGRTPEFSTIIPHLVVTEDTDEDAPLVPDDTSDSGYGTLIPGTPTG
SRSPLSRLRQRALRRDPRLTFSTLELRDIPLRPHPPDPQAPQRRSAPELPEGILKGGSLP
QEDPPTWSEEEDGASERGNVVVETLHRARLRGQLPSSPTHADSAGESPWESSGEEEEEGP
LFLKAGHTSLRPMRAEDMLREIREELASQRIEGAEEPRDSRPRKLTRAQLQRMRGPHIIQ
LDTPLSASEV
GenBank ID Protein 222080068
UniProtKB/Swiss-Prot ID Q3KR16
UniProtKB/Swiss-Prot Entry Name PKHG6_HUMAN
PDB IDs Not Available
GenBank Gene ID NM_001144856.1
GeneCard ID PLEKHG6
GenAtlas ID PLEKHG6
HGNC ID HGNC:25562
References
General References
  1. Ota T, Suzuki Y, Nishikawa T, Otsuki T, Sugiyama T, Irie R, Wakamatsu A, Hayashi K, Sato H, Nagai K, Kimura K, Makita H, Sekine M, Obayashi M, Nishi T, Shibahara T, Tanaka T, Ishii S, Yamamoto J, Saito K, Kawai Y, Isono Y, Nakamura Y, Nagahari K, Murakami K, Yasuda T, Iwayanagi T, Wagatsuma M, Shiratori A, Sudo H, Hosoiri T, Kaku Y, Kodaira H, Kondo H, Sugawara M, Takahashi M, Kanda K, Yokoi T, Furuya T, Kikkawa E, Omura Y, Abe K, Kamihara K, Katsuta N, Sato K, Tanikawa M, Yamazaki M, Ninomiya K, Ishibashi T, Yamashita H, Murakawa K, Fujimori K, Tanai H, Kimata M, Watanabe M, Hiraoka S, Chiba Y, Ishida S, Ono Y, Takiguchi S, Watanabe S, Yosida M, Hotuta T, Kusano J, Kanehori K, Takahashi-Fujii A, Hara H, Tanase TO, Nomura Y, Togiya S, Komai F, Hara R, Takeuchi K, Arita M, Imose N, Musashino K, Yuuki H, Oshima A, Sasaki N, Aotsuka S, Yoshikawa Y, Matsunawa H, Ichihara T, Shiohata N, Sano S, Moriya S, Momiyama H, Satoh N, Takami S, Terashima Y, Suzuki O, Nakagawa S, Senoh A, Mizoguchi H, Goto Y, Shimizu F, Wakebe H, Hishigaki H, Watanabe T, Sugiyama A, Takemoto M, Kawakami B, Yamazaki M, Watanabe K, Kumagai A, Itakura S, Fukuzumi Y, Fujimori Y, Komiyama M, Tashiro H, Tanigami A, Fujiwara T, Ono T, Yamada K, Fujii Y, Ozaki K, Hirao M, Ohmori Y, Kawabata A, Hikiji T, Kobatake N, Inagaki H, Ikema Y, Okamoto S, Okitani R, Kawakami T, Noguchi S, Itoh T, Shigeta K, Senba T, Matsumura K, Nakajima Y, Mizuno T, Morinaga M, Sasaki M, Togashi T, Oyama M, Hata H, Watanabe M, Komatsu T, Mizushima-Sugano J, Satoh T, Shirai Y, Takahashi Y, Nakagawa K, Okumura K, Nagase T, Nomura N, Kikuchi H, Masuho Y, Yamashita R, Nakai K, Yada T, Nakamura Y, Ohara O, Isogai T, Sugano S: Complete sequencing and characterization of 21,243 full-length human cDNAs. Nat Genet. 2004 Jan;36(1):40-5. Epub 2003 Dec 21. [PubMed:14702039 ]
  2. Gerhard DS, Wagner L, Feingold EA, Shenmen CM, Grouse LH, Schuler G, Klein SL, Old S, Rasooly R, Good P, Guyer M, Peck AM, Derge JG, Lipman D, Collins FS, Jang W, Sherry S, Feolo M, Misquitta L, Lee E, Rotmistrovsky K, Greenhut SF, Schaefer CF, Buetow K, Bonner TI, Haussler D, Kent J, Kiekhaus M, Furey T, Brent M, Prange C, Schreiber K, Shapiro N, Bhat NK, Hopkins RF, Hsie F, Driscoll T, Soares MB, Casavant TL, Scheetz TE, Brown-stein MJ, Usdin TB, Toshiyuki S, Carninci P, Piao Y, Dudekula DB, Ko MS, Kawakami K, Suzuki Y, Sugano S, Gruber CE, Smith MR, Simmons B, Moore T, Waterman R, Johnson SL, Ruan Y, Wei CL, Mathavan S, Gunaratne PH, Wu J, Garcia AM, Hulyk SW, Fuh E, Yuan Y, Sneed A, Kowis C, Hodgson A, Muzny DM, McPherson J, Gibbs RA, Fahey J, Helton E, Ketteman M, Madan A, Rodrigues S, Sanchez A, Whiting M, Madari A, Young AC, Wetherby KD, Granite SJ, Kwong PN, Brinkley CP, Pearson RL, Bouffard GG, Blakesly RW, Green ED, Dickson MC, Rodriguez AC, Grimwood J, Schmutz J, Myers RM, Butterfield YS, Griffith M, Griffith OL, Krzywinski MI, Liao N, Morin R, Palmquist D, Petrescu AS, Skalska U, Smailus DE, Stott JM, Schnerch A, Schein JE, Jones SJ, Holt RA, Baross A, Marra MA, Clifton S, Makowski KA, Bosak S, Malek J: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). Genome Res. 2004 Oct;14(10B):2121-7. [PubMed:15489334 ]
  3. Scherer SE, Muzny DM, Buhay CJ, Chen R, Cree A, Ding Y, Dugan-Rocha S, Gill R, Gunaratne P, Harris RA, Hawes AC, Hernandez J, Hodgson AV, Hume J, Jackson A, Khan ZM, Kovar-Smith C, Lewis LR, Lozado RJ, Metzker ML, Milosavljevic A, Miner GR, Montgomery KT, Morgan MB, Nazareth LV, Scott G, Sodergren E, Song XZ, Steffen D, Lovering RC, Wheeler DA, Worley KC, Yuan Y, Zhang Z, Adams CQ, Ansari-Lari MA, Ayele M, Brown MJ, Chen G, Chen Z, Clerc-Blankenburg KP, Davis C, Delgado O, Dinh HH, Draper H, Gonzalez-Garay ML, Havlak P, Jackson LR, Jacob LS, Kelly SH, Li L, Li Z, Liu J, Liu W, Lu J, Maheshwari M, Nguyen BV, Okwuonu GO, Pasternak S, Perez LM, Plopper FJ, Santibanez J, Shen H, Tabor PE, Verduzco D, Waldron L, Wang Q, Williams GA, Zhang J, Zhou J, Allen CC, Amin AG, Anyalebechi V, Bailey M, Barbaria JA, Bimage KE, Bryant NP, Burch PE, Burkett CE, Burrell KL, Calderon E, Cardenas V, Carter K, Casias K, Cavazos I, Cavazos SR, Ceasar H, Chacko J, Chan SN, Chavez D, Christopoulos C, Chu J, Cockrell R, Cox CD, Dang M, Dathorne SR, David R, Davis CM, Davy-Carroll L, Deshazo DR, Donlin JE, D'Souza L, Eaves KA, Egan A, Emery-Cohen AJ, Escotto M, Flagg N, Forbes LD, Gabisi AM, Garza M, Hamilton C, Henderson N, Hernandez O, Hines S, Hogues ME, Huang M, Idlebird DG, Johnson R, Jolivet A, Jones S, Kagan R, King LM, Leal B, Lebow H, Lee S, LeVan JM, Lewis LC, London P, Lorensuhewa LM, Loulseged H, Lovett DA, Lucier A, Lucier RL, Ma J, Madu RC, Mapua P, Martindale AD, Martinez E, Massey E, Mawhiney S, Meador MG, Mendez S, Mercado C, Mercado IC, Merritt CE, Miner ZL, Minja E, Mitchell T, Mohabbat F, Mohabbat K, Montgomery B, Moore N, Morris S, Munidasa M, Ngo RN, Nguyen NB, Nickerson E, Nwaokelemeh OO, Nwokenkwo S, Obregon M, Oguh M, Oragunye N, Oviedo RJ, Parish BJ, Parker DN, Parrish J, Parks KL, Paul HA, Payton BA, Perez A, Perrin W, Pickens A, Primus EL, Pu LL, Puazo M, Quiles MM, Quiroz JB, Rabata D, Reeves K, Ruiz SJ, Shao H, Sisson I, Sonaike T, Sorelle RP, Sutton AE, Svatek AF, Svetz LA, Tamerisa KS, Taylor TR, Teague B, Thomas N, Thorn RD, Trejos ZY, Trevino BK, Ukegbu ON, Urban JB, Vasquez LI, Vera VA, Villasana DM, Wang L, Ward-Moore S, Warren JT, Wei X, White F, Williamson AL, Wleczyk R, Wooden HS, Wooden SH, Yen J, Yoon L, Yoon V, Zorrilla SE, Nelson D, Kucherlapati R, Weinstock G, Gibbs RA: The finished DNA sequence of human chromosome 12. Nature. 2006 Mar 16;440(7082):346-51. [PubMed:16541075 ]
  4. Wan D, Gong Y, Qin W, Zhang P, Li J, Wei L, Zhou X, Li H, Qiu X, Zhong F, He L, Yu J, Yao G, Jiang H, Qian L, Yu Y, Shu H, Chen X, Xu H, Guo M, Pan Z, Chen Y, Ge C, Yang S, Gu J: Large-scale cDNA transfection screening for genes related to cancer development and progression. Proc Natl Acad Sci U S A. 2004 Nov 2;101(44):15724-9. Epub 2004 Oct 21. [PubMed:15498874 ]
  5. Wu D, Asiedu M, Adelstein RS, Wei Q: A novel guanine nucleotide exchange factor MyoGEF is required for cytokinesis. Cell Cycle. 2006 Jun;5(11):1234-9. Epub 2006 Jun 1. [PubMed:16721066 ]
  6. D'Angelo R, Aresta S, Blangy A, Del Maestro L, Louvard D, Arpin M: Interaction of ezrin with the novel guanine nucleotide exchange factor PLEKHG6 promotes RhoG-dependent apical cytoskeleton rearrangements in epithelial cells. Mol Biol Cell. 2007 Dec;18(12):4780-93. Epub 2007 Sep 19. [PubMed:17881735 ]