Hmdb loader
Identification
HMDB Protein ID HMDBP11469
Secondary Accession Numbers
  • 17818
Name PH and SEC7 domain-containing protein 1
Synonyms
  1. Exchange factor for ARF6
  2. Pleckstrin homology and SEC7 domain-containing protein 1
Gene Name PSD
Protein Type Unknown
Biological Properties
General Function Involved in ARF guanyl-nucleotide exchange factor activity
Specific Function Guanine nucleotide exchange factor for ARF6
Pathways Not Available
Reactions Not Available
GO Classification
Component
cell part
intracellular
Function
small gtpase regulator activity
enzyme regulator activity
arf guanyl-nucleotide exchange factor activity
nucleoside-triphosphatase regulator activity
gtpase regulator activity
Process
regulation of ras protein signal transduction
biological regulation
regulation of biological process
regulation of arf protein signal transduction
regulation of cellular process
regulation of cell communication
regulation of signal transduction
regulation of small gtpase mediated signal transduction
Cellular Location Not Available
Gene Properties
Chromosome Location Chromosome:1
Locus 10q24
SNPs PSD
Gene Sequence
>3075 bp
ATGGCCCAGGGTGCCATGCGCTTCTGCTCGGAAGGCGACTGTGCCATCTCCCCACCACGA
TGCCCACGCCGCTGGCTCCCCGAAGGCCCGGTGCCCCAGAGCCCCCCAGCCAGCATGTAT
GGCAGCACAGGCTCCTTGCTACGGCGAGTGGCAGGTCCAGGTCCTCGAGGCCGGGAACTG
GGACGTGTGACAGCACCCTGTACACCTCTGCGTGGCCCCCCCTCACCCCGTGTTGCTCCC
TCACCCTGGGCACCCTCTTCACCCACTGGGCAGCCCCCACCCGGGGCCCAGAGCTCTGTG
GTCATCTTCCGCTTTGTGGAGAAGGCCAGTGTGAGGCCACTGAATGGGCTACCTGCTCCA
GGGGGCTTGAGTCGGAGCTGGGATCTGGGTGGGGTTTCTCCTCCCAGGCCCACCCCAGCC
CTTGGGCCTGGCTCCAACCGGAAGTTACGGCTGGAAGCATCCACATCAGACCCACTCCCC
GCCAGAGGAGGCTCGGCCCTACCTGGCAGCCGGAACCTTGTACATGGGCCGCCAGCCCCA
CCCCAGGTTGGAGCAGATGGCCTTTACTCCTCTCTCCCCAATGGGCTGGGGGGCCCCCCT
GAGCGCCTGGCCACACTCTTCGGAGGACCTGCTGACACTGGATTCCTGAACCAGGGGGAT
ACCTGGTCCTCCCCCCGGGAAGTCTCCTCTCATGCCCAGAGAATCGCTAGAGCCAAATGG
GAATTCTTCTATGGCTCCTTGGACCCCCCCAGCTCAGGTGCTAAGCCCCCAGAGCAGGCC
CCCCCATCTCCACCTGGGGTGGGCTCAAGGCAGGGCTCTGGGGTGGCTGTGGGGCGAGCA
GCCAAGTACTCCGAGACAGACCTGGACACGGTGCCCCTGAGGTGCTACCGCGAGACTGAC
ATCGATGAGGTGCTGGCTGAGCGGGAGGAGGCCGACTCGGCCATCGAAAGTCAGCCCAGC
TCTGAGGGCCCACCAGGCACTGCCTACCCACCTGCCCCACGGCCCGGCCCACTCCCTGGC
CCTCATCCCAGCCTCGGCAGTGGCAATGAGGATGAGGACGACGATGAGGCAGGTGGGGAA
GAAGATGTGGACGACGAGGTGTTTGAGGCCTCTGAAGGGGCCCGGCCAGGGAGCCGGATG
CCTCTCAAGTCACCTGTGCCCTTTCTACCTGGGACGAGCCCCTCGGCTGATGGGCCTGAC
TCTTTCAGTTGTGTGTTCGAAGCCATCCTGGAGTCACACCGGGCCAAAGGCACCTCCTAT
ACCAGCCTCGCCTCGCTGGAGGCCTTGGCCTCACCTGGCCCAACCCAGAGCCCCTTCTTC
ACCTTTGAGCTGCCTCCCCAACCCCCTGCACCCCGGCCCGACCCACCAGCTCCCGCCCCA
CTTGCCCCTCTTGAACCGGATTCTGGTACCAGCTCTGCTGCTGATGGTCCTTGGACACAG
AGAGGGGAGGAGGAGGAGGCAGAGGCCAGAGCCAAGCTGGCCCCAGGGAGGGAGCCCCCT
AGTCCCTGCCACTCAGAGGACAGCCTTGGGCTGGGGGCAGCACCCCTTGGCAGCGAACCA
CCCCTGAGCCAGCTGGTGTCCGACTCAGACTCAGAGCTGGACAGCACAGAGCGGCTGGCC
CTGGGAAGCACAGACACCTTGTCCAATGGGCAGAAAGCGGACCTGGAGGCTGCGCAGCGC
CTGGCCAAGAGGCTGTACCGACTAGATGGCTTCAGGAAGGCCGATGTGGCCCGGCACCTG
GGCAAGAACAATGACTTCAGCAAACTGGTGGCTGGGGAGTACCTCAAGTTCTTTGTCTTC
ACGGGCATGACTCTGGACCAAGCTCTCAGGGTGTTTCTGAAGGAGCTGGCCTTAATGGGT
GAGACCCAGGAACGAGAGCGCGTGCTGGCCCACTTCTCCCAGCGATACTTCCAGTGCAAT
CCTGAAGCCCTGTCCTCAGAGGACGGCGCCCACACGCTGACCTGTGCGCTCATGCTGCTC
AACACGGATCTCCACGGCCATAACATCGGGAAGCGCATGACCTGCGGGGACTTCATCGGG
AACCTGGAGGGCCTCAATGATGGCGGCGACTTCCCTAGGGAGCTGCTCAAGGCCTTGTAC
AGCTCCATCAAGAATGAGAAGCTGCAGTGGGCCATAGACGAGGAGGAGCTGAGACGCTCT
CTGTCTGAGTTGGCCGACCCCAACCCCAAGGTCATCAAGCGGATCAGCGGGGGCAGTGGC
AGTGGCTCCAGCCCTTTCCTGGACCTGACTCCCGAGCCTGGGGCTGCCGTCTACAAGCAC
GGGGCCCTGGTGCGAAAGGTGCACGCAGACCCTGACTGCAGGAAGACACCTCGGGGCAAG
CGGGGCTGGAAGAGCTTCCACGGGATCCTCAAGGGCATGATCCTCTACCTGCAGAAGGAG
GAGTACAAGCCTGGGAAGGCCCTTTCAGAGACGGAGCTCAAGAATGCCATCAGCATCCAC
CATGCCCTGGCCACTCGTGCCAGTGACTACAGCAAGAGGCCCCACGTCTTCTACCTGCGC
ACAGCTGACTGGCGGGTCTTCCTCTTCCAGGCCCCGAGCCTGGAGCAGATGCAGTCCTGG
ATCACTCGCATCAATGTAGTAGCCGCTATGTTCTCTGCGCCCCCCTTCCCAGCTGCTGTT
AGCTCCCAAAAGAAGTTCAGCCGCCCTCTCCTGCCCAGCGCTGCCACCCGCCTCTCCCAG
GAGGAGCAGGTGCGGACCCACGAGGCCAAGCTGAAGGCCATGGCAAGTGAGCTGCGGGAG
CACCGGGCCGCCCAGCTGGGCAAGAAGGGCCGGGGCAAGGAGGCTGAAGAGCAGCGGCAG
AAGGAGGCCTACCTGGAGTTTGAGAAATCCCGCTACAGCACCTATGCAGCGCTGCTTCGG
GTCAAGCTGAAGGCAGGCAGTGAGGAGCTGGATGCAGTGGAGGCAGCACTGGCCCAGGCC
GGGAGCACAGAGGATGGACTCCCTCCTTCTCACTCCAGTCCCTCCCTGCAGCCCAAACCC
TCCAGCCAGCCCCGGGCTCAGCGTCACAGCTCAGAGCCTCGGCCAGGGGCAGGCAGTGGG
CGGCGGAAGCCCTGA
Protein Properties
Number of Residues 1024
Molecular Weight 109541.6
Theoretical pI 6.86
Pfam Domain Function
Signals
  • None
Transmembrane Regions
  • None
Protein Sequence
>PH and SEC7 domain-containing protein 1
MAQGAMRFCSEGDCAISPPRCPRRWLPEGPVPQSPPASMYGSTGSLLRRVAGPGPRGREL
GRVTAPCTPLRGPPSPRVAPSPWAPSSPTGQPPPGAQSSVVIFRFVEKASVRPLNGLPAP
GGLSRSWDLGGVSPPRPTPALGPGSNRKLRLEASTSDPLPARGGSALPGSRNLVHGPPAP
PQVGADGLYSSLPNGLGGPPERLATLFGGPADTGFLNQGDTWSSPREVSSHAQRIARAKW
EFFYGSLDPPSSGAKPPEQAPPSPPGVGSRQGSGVAVGRAAKYSETDLDTVPLRCYRETD
IDEVLAEREEADSAIESQPSSEGPPGTAYPPAPRPGPLPGPHPSLGSGNEDEDDDEAGGE
EDVDDEVFEASEGARPGSRMPLKSPVPFLPGTSPSADGPDSFSCVFEAILESHRAKGTSY
TSLASLEALASPGPTQSPFFTFELPPQPPAPRPDPPAPAPLAPLEPDSGTSSAADGPWTQ
RGEEEEAEARAKLAPGREPPSPCHSEDSLGLGAAPLGSEPPLSQLVSDSDSELDSTERLA
LGSTDTLSNGQKADLEAAQRLAKRLYRLDGFRKADVARHLGKNNDFSKLVAGEYLKFFVF
TGMTLDQALRVFLKELALMGETQERERVLAHFSQRYFQCNPEALSSEDGAHTLTCALMLL
NTDLHGHNIGKRMTCGDFIGNLEGLNDGGDFPRELLKALYSSIKNEKLQWAIDEEELRRS
LSELADPNPKVIKRISGGSGSGSSPFLDLTPEPGAAVYKHGALVRKVHADPDCRKTPRGK
RGWKSFHGILKGMILYLQKEEYKPGKALSETELKNAISIHHALATRASDYSKRPHVFYLR
TADWRVFLFQAPSLEQMQSWITRINVVAAMFSAPPFPAAVSSQKKFSRPLLPSAATRLSQ
EEQVRTHEAKLKAMASELREHRAAQLGKKGRGKEAEEQRQKEAYLEFEKSRYSTYAALLR
VKLKAGSEELDAVEAALAQAGSTEDGLPPSHSSPSLQPKPSSQPRAQRHSSEPRPGAGSG
RRKP
GenBank ID Protein 56790299
UniProtKB/Swiss-Prot ID A5PKW4
UniProtKB/Swiss-Prot Entry Name PSD1_HUMAN
PDB IDs Not Available
GenBank Gene ID NM_002779.3
GeneCard ID PSD
GenAtlas ID PSD
HGNC ID HGNC:9507
References
General References
  1. Gerhard DS, Wagner L, Feingold EA, Shenmen CM, Grouse LH, Schuler G, Klein SL, Old S, Rasooly R, Good P, Guyer M, Peck AM, Derge JG, Lipman D, Collins FS, Jang W, Sherry S, Feolo M, Misquitta L, Lee E, Rotmistrovsky K, Greenhut SF, Schaefer CF, Buetow K, Bonner TI, Haussler D, Kent J, Kiekhaus M, Furey T, Brent M, Prange C, Schreiber K, Shapiro N, Bhat NK, Hopkins RF, Hsie F, Driscoll T, Soares MB, Casavant TL, Scheetz TE, Brown-stein MJ, Usdin TB, Toshiyuki S, Carninci P, Piao Y, Dudekula DB, Ko MS, Kawakami K, Suzuki Y, Sugano S, Gruber CE, Smith MR, Simmons B, Moore T, Waterman R, Johnson SL, Ruan Y, Wei CL, Mathavan S, Gunaratne PH, Wu J, Garcia AM, Hulyk SW, Fuh E, Yuan Y, Sneed A, Kowis C, Hodgson A, Muzny DM, McPherson J, Gibbs RA, Fahey J, Helton E, Ketteman M, Madan A, Rodrigues S, Sanchez A, Whiting M, Madari A, Young AC, Wetherby KD, Granite SJ, Kwong PN, Brinkley CP, Pearson RL, Bouffard GG, Blakesly RW, Green ED, Dickson MC, Rodriguez AC, Grimwood J, Schmutz J, Myers RM, Butterfield YS, Griffith M, Griffith OL, Krzywinski MI, Liao N, Morin R, Palmquist D, Petrescu AS, Skalska U, Smailus DE, Stott JM, Schnerch A, Schein JE, Jones SJ, Holt RA, Baross A, Marra MA, Clifton S, Makowski KA, Bosak S, Malek J: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). Genome Res. 2004 Oct;14(10B):2121-7. [PubMed:15489334 ]
  2. Deloukas P, Earthrowl ME, Grafham DV, Rubenfield M, French L, Steward CA, Sims SK, Jones MC, Searle S, Scott C, Howe K, Hunt SE, Andrews TD, Gilbert JG, Swarbreck D, Ashurst JL, Taylor A, Battles J, Bird CP, Ainscough R, Almeida JP, Ashwell RI, Ambrose KD, Babbage AK, Bagguley CL, Bailey J, Banerjee R, Bates K, Beasley H, Bray-Allen S, Brown AJ, Brown JY, Burford DC, Burrill W, Burton J, Cahill P, Camire D, Carter NP, Chapman JC, Clark SY, Clarke G, Clee CM, Clegg S, Corby N, Coulson A, Dhami P, Dutta I, Dunn M, Faulkner L, Frankish A, Frankland JA, Garner P, Garnett J, Gribble S, Griffiths C, Grocock R, Gustafson E, Hammond S, Harley JL, Hart E, Heath PD, Ho TP, Hopkins B, Horne J, Howden PJ, Huckle E, Hynds C, Johnson C, Johnson D, Kana A, Kay M, Kimberley AM, Kershaw JK, Kokkinaki M, Laird GK, Lawlor S, Lee HM, Leongamornlert DA, Laird G, Lloyd C, Lloyd DM, Loveland J, Lovell J, McLaren S, McLay KE, McMurray A, Mashreghi-Mohammadi M, Matthews L, Milne S, Nickerson T, Nguyen M, Overton-Larty E, Palmer SA, Pearce AV, Peck AI, Pelan S, Phillimore B, Porter K, Rice CM, Rogosin A, Ross MT, Sarafidou T, Sehra HK, Shownkeen R, Skuce CD, Smith M, Standring L, Sycamore N, Tester J, Thorpe A, Torcasso W, Tracey A, Tromans A, Tsolas J, Wall M, Walsh J, Wang H, Weinstock K, West AP, Willey DL, Whitehead SL, Wilming L, Wray PW, Young L, Chen Y, Lovering RC, Moschonas NK, Siebert R, Fechtel K, Bentley D, Durbin R, Hubbard T, Doucette-Stamm L, Beck S, Smith DR, Rogers J: The DNA sequence and comparative analysis of human chromosome 10. Nature. 2004 May 27;429(6990):375-81. [PubMed:15164054 ]
  3. Perletti L, Talarico D, Trecca D, Ronchetti D, Fracchiolla NS, Maiolo AT, Neri A: Identification of a novel gene, PSD, adjacent to NFKB2/lyt-10, which contains Sec7 and pleckstrin-homology domains. Genomics. 1997 Dec 1;46(2):251-9. [PubMed:9417912 ]