| Identification |
|---|
| HMDB Protein ID
| HMDBP11470 |
| Secondary Accession Numbers
| |
| Name
| Guanine nucleotide-binding protein G(o) subunit alpha |
| Synonyms
|
Not Available
|
| Gene Name
| GNAO1 |
| Protein Type
| Unknown |
| Biological Properties |
|---|
| General Function
| Involved in signal transducer activity |
| Specific Function
| Guanine nucleotide-binding proteins (G proteins) are involved as modulators or transducers in various transmembrane signaling systems. The G(o) protein function is not clear |
| Pathways
|
Not Available
|
| Reactions
| Not Available |
| GO Classification
|
| Function |
| purine nucleotide binding |
| binding |
| nucleotide binding |
| guanyl nucleotide binding |
| guanyl ribonucleotide binding |
| gtp binding |
| molecular transducer activity |
| signal transducer activity |
| Process |
| biological regulation |
| regulation of biological process |
| regulation of cellular process |
| signal transduction |
| signaling |
| signaling pathway |
| cell surface receptor linked signaling pathway |
| g-protein coupled receptor protein signaling pathway |
|
| Cellular Location
|
Not Available
|
| Gene Properties |
|---|
| Chromosome Location
| Chromosome:1 |
| Locus
| 16q13 |
| SNPs
| GNAO1 |
| Gene Sequence
|
>1065 bp
ATGGGATGTACTCTGAGCGCAGAGGAGAGAGCCGCCCTCGAGCGGAGCAAGGCGATTGAG
AAAAACCTCAAAGAGGATGGCATCAGCGCCGCCAAAGACGTGAAATTACTCCTGCTCGGG
GCTGGAGAATCAGGAAAAAGCACCATTGTGAAGCAGATGAAGATCATCCATGAAGATGGC
TTCTCCGGAGAAGACGTGAAACAGTACAAGCCTGTTGTCTACAGCAACACTATCCAGTCC
CTGGCAGCCATCGTCCGGGCCATGGACACTTTGGGCATCGAATATGGTGATAAGGAGAGA
AAGGCTGACGCCAAGATGGTGTGTGATGTGGTGAGTCGGATGGAAGACACCGAGCCCTTC
TCTGCAGAGCTGCTTTCTGCCATGATGCGGCTCTGGGGCGACTCAGGAATCCAAGAGTGC
TTCAACCGGTCCCGGGAGTATCAGCTCAACGACTCTGCCAAATACTACCTGGACAGCCTG
GATCGGATTGGGGCCGCCGACTACCAGCCCACCGAGCAGGACATCCTCCGAACCAGGGTC
AAAACCACTGGCATCGTAGAAACCCACTTCACATTCAAGAACCTCCACTTCAGGCTGTTT
GACGTCGGAGGCCAGCGATCTGAACGCAAGAAGTGGATCCATTGCTTCGAGGACGTCACG
GCCATCATTTTCTGTGTCGCGCTCAGCGGCTATGACCAGGTGCTCCACGAAGACGAAACC
ACGAACCGCATGCACGAGTCTCTCATGCTCTTCGACTCCATCTGTAACAACAAGTTCTTC
ATCGATACCTCCATCATTCTCTTCCTCAACAAGAAAGATCTCTTTGGCGAGAAGATCAAG
AAGTCACCTTTGACCATCTGCTTTCCTGAATACACAGGCCCCAATACCTATGAAGACGCA
GCCGCCTACATCCAAGCACAATTTGAAAGCAAAAACCGCTCACCCAACAAAGAAATATAT
TGTCACATGACTTGTGCCACAGACACGAATAACATCCAGGTGGTGTTCGACGCCGTCACC
GACATCATCATTGCCAACAACCTCCGGGGCTGCGGCTTGTACTGA
|
| Protein Properties |
|---|
| Number of Residues
| 354 |
| Molecular Weight
| 40050.2 |
| Theoretical pI
| 5.19 |
| Pfam Domain Function
|
|
| Signals
|
|
|
Transmembrane Regions
|
|
| Protein Sequence
|
>Guanine nucleotide-binding protein G(o) subunit alpha
MGCTLSAEERAALERSKAIEKNLKEDGISAAKDVKLLLLGAGESGKSTIVKQMKIIHEDG
FSGEDVKQYKPVVYSNTIQSLAAIVRAMDTLGIEYGDKERKADAKMVCDVVSRMEDTEPF
SAELLSAMMRLWGDSGIQECFNRSREYQLNDSAKYYLDSLDRIGAADYQPTEQDILRTRV
KTTGIVETHFTFKNLHFRLFDVGGQRSERKKWIHCFEDVTAIIFCVALSGYDQVLHEDET
TNRMHESLMLFDSICNNKFFIDTSIILFLNKKDLFGEKIKKSPLTICFPEYTGPNTYEDA
AAYIQAQFESKNRSPNKEIYCHMTCATDTNNIQVVFDAVTDIIIANNLRGCGLY
|
| External Links |
|---|
| GenBank ID Protein
| 20147681 |
| UniProtKB/Swiss-Prot ID
| P09471 |
| UniProtKB/Swiss-Prot Entry Name
| GNAO_HUMAN |
| PDB IDs
|
Not Available |
| GenBank Gene ID
| AF493894 |
| GeneCard ID
| GNAO1 |
| GenAtlas ID
| GNAO1 |
| HGNC ID
| HGNC:4389 |
| References |
|---|
| General References
| - Tsukamoto T, Toyama R, Itoh H, Kozasa T, Matsuoka M, Kaziro Y: Structure of the human gene and two rat cDNAs encoding the alpha chain of GTP-binding regulatory protein Go: two different mRNAs are generated by alternative splicing. Proc Natl Acad Sci U S A. 1991 Apr 15;88(8):2974-8. [PubMed:1901650 ]
- Lavu S, Clark J, Swarup R, Matsushima K, Paturu K, Moss J, Kung HF: Molecular cloning and DNA sequence analysis of the human guanine nucleotide-binding protein Go alpha. Biochem Biophys Res Commun. 1988 Jan 29;150(2):811-5. [PubMed:3124840 ]
- Duc-Goiran P, Bourgeois C, Mignot TM, Robert B, Tanguy G, Ferre F: Identification and expression of Go1 and Go2 alpha-subunit transcripts in human myometrium in relation to pregnancy. Biol Reprod. 1999 Jun;60(6):1528-35. [PubMed:10330115 ]
|
