Hmdb loader
Identification
HMDB Protein ID HMDBP11474
Secondary Accession Numbers
  • 17823
Name Switch-associated protein 70
Synonyms
  1. SWAP-70
Gene Name SWAP70
Protein Type Unknown
Biological Properties
General Function Involved in calcium ion binding
Specific Function Phosphatidylinositol 3,4,5-trisphosphate-dependent guanine nucleotide exchange factor (GEF) which, independently of RAS, transduces signals from tyrosine kinase receptors to RAC. It also mediates signaling of membrane ruffling. Regulates the actin cytoskeleton as an effector or adapter protein in response to agonist stimulated phosphatidylinositol (3,4)-bisphosphate production and cell protrusion
Pathways Not Available
Reactions Not Available
GO Classification Not Available
Cellular Location
  1. Cell membrane
  2. Nucleus
  3. Cytoplasm
  4. Cell projection
  5. lamellipodium
Gene Properties
Chromosome Location Chromosome:1
Locus 11p15
SNPs SWAP70
Gene Sequence
>1758 bp
ATGGGGAGCTTGAAGGAGGAGCTGCTCAAAGCCATCTGGCACGCCTTCACCGCACTCGAC
CAGGACCACAGCGGCAAGGTCTCCAAGTCCCAGCTCAAGGTCCTTTCCCATAACCTGTGC
ACGGTGCTGAAGGTTCCTCATGACCCAGTTGCCCTTGAAGAGCACTTCAGGGATGATGAT
GAGGGTCCAGTGTCCAACCAGGGCTACATGCCTTATTTAAACAGGTTCATTTTGGAAAAG
GTCCAAGACAACTTTGACAAGATTGAATTCAATAGGATGTGTTGGACCCTCTGTGTCAAA
AAAAACCTCACAAAGAATCCCCTGCTCATTACAGAAGAAGATGCATTTAAAATATGGGTT
ATTTTCAACTTTTTATCTGAGGACAAGTATCCATTAATTATTGTGTCAGAAGAGATTGAA
TACCTGCTTAAGAAGCTTACAGAAGCTATGGGAGGAGGTTGGCAGCAAGAACAATTTGAA
CATTATAAAATCAACTTTGATGACAGTAAAAATGGCCTTTCTGCATGGGAACTTATTGAG
CTTATTGGAAATGGACAGTTTAGCAAAGGCATGGACCGGCAGACTGTGTCTATGGCAATT
AATGAAGTCTTTAATGAACTTATATTAGATGTGTTAAAGCAGGGTTACATGATGAAAAAG
GGCCACAGACGGAAAAACTGGACTGAAAGATGGTTTGTACTAAAACCCAACATAATTTCT
TACTATGTGAGTGAGGATCTGAAGGATAAGAAAGGAGACATTCTCTTGGATGAAAATTGC
TGTGTAGAGTCCTTGCCTGACAAAGATGGAAAGAAATGCCTTTTTCTCGTAAAATGTTTT
GATAAGACTTTTGAAATCAGTGCTTCAGATAAGAAGAAGAAACAGGAGTGGATTCAAGCC
ATTCATTCTACTATTCATCTGTTGAAGCTGGGCAGCCCTCCACCACACAAAGAAGCCCGC
CAGCGTCGGAAAGAACTCCGGAAGAAGCAGCTGGCTGAACAAGAGGAACTGGAGCGACAA
ATGAAGGAACTCCAGGCCGCCAACGAAAGCAAGCAGCAGGAGCTGGAGGCCGTGCGGAAG
AAACTGGAGGAAGCAGCATCTCGTGCAGCAGAAGAGGAAAAGAAACGCCTTCAGACTCAA
GTGGAACTTCAGGCCAGGTTCAGCACAGAGCTGGAAAGAGAGAAGCTTATCAGACAGCAG
ATGGAAGAACAGGTTGCTCAAAAGTCCTCTGAACTGGAACAGTATTTACAGCGAGTACGG
GAGCTGGAAGACATGTACCTAAAGCTGCAGGAGGCTCTTGAAGATGAGAGACAGGCCCGG
CAAGATGAAGAGACAGTGCGGAAGCTTCAGGCCAGGTTGTTGGAGGAAGAGTCTTCCAAG
AGGGCTGAACTAGAAAAGTGGCACTTGGAGCAGCAGCAGGCCATTCAGACAACCGAGGCG
GAGAAGCAGGAGTTGGAGAATCAGCGTGTCCTGAAGGAACAGGCCCTGCAGGAGGCCATG
GAGCAGCTGGAGCAGCTTGAGTTAGAACGGAAGCAAGCACTTGAGCAGTACGAGGAAGTT
AAAAAGAAGCTGGAGATGGCAACTAATAAGACCAAGAGCTGGAAGGACAAAGTGGCCCAT
CATGAAGGATTAATTCGACTGATAGAACCAGGTTCAAAGAACCCTCACCTGATCACTAAC
TGGGGACCTGCAGCTTTCACTGAGGCAGAACTTGAAGAGAGAGAGAAGAACTGGAAAGAG
AAAAAGACCACGGAGTGA
Protein Properties
Number of Residues 585
Molecular Weight 68997.2
Theoretical pI 5.65
Pfam Domain Function
Signals
  • None
Transmembrane Regions
  • None
Protein Sequence
>Switch-associated protein 70
MGSLKEELLKAIWHAFTALDQDHSGKVSKSQLKVLSHNLCTVLKVPHDPVALEEHFRDDD
EGPVSNQGYMPYLNRFILEKVQDNFDKIEFNRMCWTLCVKKNLTKNPLLITEEDAFKIWV
IFNFLSEDKYPLIIVSEEIEYLLKKLTEAMGGGWQQEQFEHYKINFDDSKNGLSAWELIE
LIGNGQFSKGMDRQTVSMAINEVFNELILDVLKQGYMMKKGHRRKNWTERWFVLKPNIIS
YYVSEDLKDKKGDILLDENCCVESLPDKDGKKCLFLVKCFDKTFEISASDKKKKQEWIQA
IHSTIHLLKLGSPPPHKEARQRRKELRKKQLAEQEELERQMKELQAANESKQQELEAVRK
KLEEAASRAAEEEKKRLQTQVELQARFSTELEREKLIRQQMEEQVAQKSSELEQYLQRVR
ELEDMYLKLQEALEDERQARQDEETVRKLQARLLEEESSKRAELEKWHLEQQQAIQTTEA
EKQELENQRVLKEQALQEAMEQLEQLELERKQALEQYEEVKKKLEMATNKTKSWKDKVAH
HEGLIRLIEPGSKNPHLITNWGPAAFTEAELEEREKNWKEKKTTE
GenBank ID Protein 93102364
UniProtKB/Swiss-Prot ID Q9UH65
UniProtKB/Swiss-Prot Entry Name SWP70_HUMAN
PDB IDs Not Available
GenBank Gene ID NM_015055.2
GeneCard ID SWAP70
GenAtlas ID SWAP70
HGNC ID HGNC:17070
References
General References
  1. Gerhard DS, Wagner L, Feingold EA, Shenmen CM, Grouse LH, Schuler G, Klein SL, Old S, Rasooly R, Good P, Guyer M, Peck AM, Derge JG, Lipman D, Collins FS, Jang W, Sherry S, Feolo M, Misquitta L, Lee E, Rotmistrovsky K, Greenhut SF, Schaefer CF, Buetow K, Bonner TI, Haussler D, Kent J, Kiekhaus M, Furey T, Brent M, Prange C, Schreiber K, Shapiro N, Bhat NK, Hopkins RF, Hsie F, Driscoll T, Soares MB, Casavant TL, Scheetz TE, Brown-stein MJ, Usdin TB, Toshiyuki S, Carninci P, Piao Y, Dudekula DB, Ko MS, Kawakami K, Suzuki Y, Sugano S, Gruber CE, Smith MR, Simmons B, Moore T, Waterman R, Johnson SL, Ruan Y, Wei CL, Mathavan S, Gunaratne PH, Wu J, Garcia AM, Hulyk SW, Fuh E, Yuan Y, Sneed A, Kowis C, Hodgson A, Muzny DM, McPherson J, Gibbs RA, Fahey J, Helton E, Ketteman M, Madan A, Rodrigues S, Sanchez A, Whiting M, Madari A, Young AC, Wetherby KD, Granite SJ, Kwong PN, Brinkley CP, Pearson RL, Bouffard GG, Blakesly RW, Green ED, Dickson MC, Rodriguez AC, Grimwood J, Schmutz J, Myers RM, Butterfield YS, Griffith M, Griffith OL, Krzywinski MI, Liao N, Morin R, Palmquist D, Petrescu AS, Skalska U, Smailus DE, Stott JM, Schnerch A, Schein JE, Jones SJ, Holt RA, Baross A, Marra MA, Clifton S, Makowski KA, Bosak S, Malek J: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). Genome Res. 2004 Oct;14(10B):2121-7. [PubMed:15489334 ]
  2. Ishikawa K, Nagase T, Suyama M, Miyajima N, Tanaka A, Kotani H, Nomura N, Ohara O: Prediction of the coding sequences of unidentified human genes. X. The complete sequences of 100 new cDNA clones from brain which can code for large proteins in vitro. DNA Res. 1998 Jun 30;5(3):169-76. [PubMed:9734811 ]
  3. Masat L, Caldwell J, Armstrong R, Khoshnevisan H, Jessberger R, Herndier B, Wabl M, Ferrick D: Association of SWAP-70 with the B cell antigen receptor complex. Proc Natl Acad Sci U S A. 2000 Feb 29;97(5):2180-4. [PubMed:10681448 ]
  4. Rapalus L, Minegishi Y, Lavoie A, Cunningham-Rundles C, Conley ME: Analysis of SWAP-70 as a candidate gene for non-X-linked hyper IgM syndrome and common variable immunodeficiency. Clin Immunol. 2001 Dec;101(3):270-5. [PubMed:11726218 ]
  5. Hilpela P, Oberbanscheidt P, Hahne P, Hund M, Kalhammer G, Small JV, Bahler M: SWAP-70 identifies a transitional subset of actin filaments in motile cells. Mol Biol Cell. 2003 Aug;14(8):3242-53. Epub 2003 Apr 17. [PubMed:12925760 ]