Hmdb loader
Identification
HMDB Protein ID HMDBP11480
Secondary Accession Numbers
  • 17829
Name Probable guanine nucleotide exchange factor MCF2L2
Synonyms
  1. Dbs-related Rho family guanine nucleotide exchange factor
  2. MCF2-transforming sequence-like protein 2
Gene Name MCF2L2
Protein Type Unknown
Biological Properties
General Function Involved in Rho guanyl-nucleotide exchange factor activity
Specific Function Probably functions as a guanine nucleotide exchange factor
Pathways Not Available
Reactions Not Available
GO Classification
Component
cell part
intracellular
Function
small gtpase regulator activity
ras guanyl-nucleotide exchange factor activity
rho guanyl-nucleotide exchange factor activity
enzyme regulator activity
nucleoside-triphosphatase regulator activity
gtpase regulator activity
Process
regulation of ras protein signal transduction
regulation of rho protein signal transduction
biological regulation
regulation of biological process
regulation of cellular process
regulation of cell communication
regulation of signal transduction
regulation of small gtpase mediated signal transduction
Cellular Location Not Available
Gene Properties
Chromosome Location Chromosome:3
Locus 3q27.1
SNPs MCF2L2
Gene Sequence
>3345 bp
ATGCTGTCTTGCTTAAAAGAAGAGATGCCTCCCCAGGAGCTCACCCGGCGACTGGCCACA
GTGATCACTCATGTCGATGAAATTATGCAGCAGGAAGTCAGACCCCTGATGGCGGTGGAG
ATAATAGAACAACTTCACAGACAATTTGCCATTCTTTCAGGAGGCCGAGGGGAGGATGGC
GCCCCCATCATCACGTTCCCAGAGTTTTCGGGGTTCAAACACATCCCAGATGAAGACTTC
CTGAATGTCATGACCTACCTGACTAGCATCCCCAGTGTGGAGGCTGCCAGCATTGGATTC
ATTGTTGTTATCGACAGACGAAGAGACAAGTGGAGCTCCGTAAAGGCATCCTTGACACGA
ATAGCTGTGGCATTTCCAGGAAACTTACAGCTCATATTCATCCTTCGTCCATCTCGCTTT
ATCCAGAGGACATTCACTGACATTGGCATTAAATACTATCGAAATGAGTTTAAAACGAAA
GTGCCGATCATCATGGTAAACTCTGTCTCTGACCTTCACGGCTACATCGACAAAAGCCAA
CTGACCCGGGAATTAGGGGGGACTTTGGAATATCGCCACGGTCAGTGGGTAAATCACCGC
ACTGCCATCGAAAACTTTGCCTTGACCTTGAAGACCACTGCCCAGATGCTGCAGACGTTT
GGGTCCTGCCTGGCCACAGCAGAGCTGCCCAGAAGCATGCTATCCACGGAAGACCTTCTC
ATGTCCCACACAAGGCAGCGGGACAAGCTGCAGGATGAGCTGAAATTACTTGGAAAGCAG
GGGACCACATTGCTGTCATGCATCCAAGAACCAGCAACCAAATGTCCCAACAGCAAACTC
AATCTCAACCAACTTGAGAATGTAACTACCATGGAAAGGTTATTAGTTCAACTGGATGAA
ACAGAAAAAGCCTTTAGTCACTTTTGGTCTGAGCATCATCTGAAGCTTAACCAGTGCCTA
CAACTACAGCATTTTGAGCACGATTTTTGTAAGGCTAAGCTTGCCCTGGATAATTTGCTG
GAAGAGCAAGCAGAGTTTACAGGCATTGGAGACAGCGTGATGCACGTGGAGCAGATTCTT
AAGGAACACAAAAAACTGGAGGAAAAAAGCCAGGAGCCCCTGGAAAAGGCCCAGCTGCTG
GCACTGGTTGGGGACCAGCTCATCCAAAGCCACCATTATGCAGCAGATGCCATCAGGCCC
CGGTGTGTGGAGCTCAGGCACCTCTGTGACGATTTCATCAATGGAAACAAGAAAAAATGG
GACATTTTAGGAAAGTCCTTAGAGTTTCATAGACAGCTGGACAAGGTCAGCCAATGGTGT
GAGGCAGGAATCTACCTCTTGGCTTCCCAAGCTGTAGACAAGTGCCAGTCTCGAGAAGGG
GTTGATATCGCCTTGAACGACATTGCGACATTCCTGGGCACAGTCAAGGAGTACCCGTTG
CTCAGCCCCAAGGAGTTTTACAACGAGTTTGAGTTGCTGCTCACCCTCGATGCAAAGGCC
AAAGCCCAGAAAGTTTTGCAGAGGCTGGATGATGTCCAGGAAATATTTCACAAGAGGCAA
GTGAGTCTGATGAAACTGGCAGCCAAACAGACTCGTCCAGTGCAACCTGTGGCCCCACAT
CCTGAGTCTTCACCAAAATGGGTGTCATCAAAAACCAGCCAGCCCTCCACCTCGGTCCCT
CTAGCTCGTCCTCTGAGAACGTCTGAGGAACCTTATACGGAGACAGAGTTGAACTCCCGG
GGAAAGGAAGATGATGAGACTAAATTTGAAGTCAAGAGTGAAGAAATCTTTGAAAGCCAT
CATGAAAGGGGGAACCCTGAGCTGGAGCAGCAGGCCAGGCTCGGAGACCTTTCCCCCCGC
AGGCGCATTATACGTGACTTGCTTGAGACTGAAGAGATTTACATAAAAGAGATTAAAAGC
ATAATTGATGGATATATCACTCCAATGGATTTTATTTGGCTAAAGCATCTAATTCCAGAT
GTTCTTCAGAATAACAAGGACTTTCTCTTTGGGAATATTAGAGAACTTTACGAATTTCAC
AACAGGACTTTTCTAAAAGAGTTGGAAAAGTGTGCTGAGAACCCTGAACTTCTGGCACAT
TGCTTTCTCAAGAGAAAAGAAGATCTTCAGATATATTTTAAATACCATAAGAATCTGCCC
CGAGCTAGGGCAATCTGGCAAGAGTGTCAAGACTGCGCCTACTTTGGGGTATGCCAGCGC
CAACTGGATCACAATCTCCCTCTTTTTAAGTATCTCAAAGGACCAAGCCAGAGACTTATA
AAATACCAGATGCTGTTGAAGGGTCTGCTGGATTTCGAGTCTCCTGAAGATATGGAGATA
GACCCAGGTGAACTAGGAGGCTCGGCTAAGGATGGGCCAAAGAGAACCAAAGATTCAGCA
TTCTCAACTGAACTACAACAAGCTTTGGCAGTGATAGAGGATTTGATCAAGTCCTGTGAG
TTGGCTGTGGACCTAGCAGCAGTGACTGAATGTCCGGACGATATTGGAAAACTAGGCAAG
CTGTTGCTGCACGGCCCTTTCAGCGTCTGGACAATTCACAAGGATCGTTATAAAATGAAG
GATTTGATTCGATTTAAACCCAGCCAGAGGCAAATCTACCTATTTGAAAGGGGAATAGTG
TTCTGTAAGATACGAATGGAGCCTGGGGACCAGGGATTATCTCCTCATTACAGCTTCAAG
AAGACCATGAAGCTGATGACACTTTCAATTCGCCAGCTTGGAAGGGGGAGCCATAGAAAG
TTTGAGATTGCCAGTCGAAATGGACTTGAGAAATACATCCTGCAGGCAGCTTCAAAAGAA
ATCAGAGACTGTTGGTTTTCAGAAATAAGTAAATTATTGATGGAACAACAAAATAATATC
AAAGACCAAGGAAATCCACAGTTTGAAATGAGCACGAGCAAAGGCAGTGGAGCAGGATCC
GGACCATGGATTAAAAATATGGAAAGAGCTACCACTAGCAAGGAAGACCCGGCCTCCAGC
ACAGGAGGGATTAAAGGCTGCTCCAGCAGGGAGTTTAGCTCCATGGACACCTTTGAAGAC
TGTGAAGGCGCAGAAGACATGGAAAAGGAGAGCAGTGCTCTGAGTCTCGCGGGCCTTTTC
CAGTCGGACGACAGTCACGAAACCTGTTCCTCCAAATCTGCTTTCCTGGAGAGGGGAGAA
AGCAGCCAGGGAGAAAAAGAAGAACGCGATGAGGAGGAAACGGCGACCCGCAGCACCGAG
GAGGAGCGCGCTGGGGCGTCCACGGGCCGGCTGGCTCCTGCGGGGGCGACGGCTGGTTTC
CAGGCGAGGGCGCTGCGCCCGAGGACCTCCGCCCAGGAGAGCTGA
Protein Properties
Number of Residues 1114
Molecular Weight 126961.6
Theoretical pI 6.37
Pfam Domain Function
Signals
  • None
Transmembrane Regions
  • None
Protein Sequence
>Probable guanine nucleotide exchange factor MCF2L2
MLSCLKEEMPPQELTRRLATVITHVDEIMQQEVRPLMAVEIIEQLHRQFAILSGGRGEDG
APIITFPEFSGFKHIPDEDFLNVMTYLTSIPSVEAASIGFIVVIDRRRDKWSSVKASLTR
IAVAFPGNLQLIFILRPSRFIQRTFTDIGIKYYRNEFKTKVPIIMVNSVSDLHGYIDKSQ
LTRELGGTLEYRHGQWVNHRTAIENFALTLKTTAQMLQTFGSCLATAELPRSMLSTEDLL
MSHTRQRDKLQDELKLLGKQGTTLLSCIQEPATKCPNSKLNLNQLENVTTMERLLVQLDE
TEKAFSHFWSEHHLKLNQCLQLQHFEHDFCKAKLALDNLLEEQAEFTGIGDSVMHVEQIL
KEHKKLEEKSQEPLEKAQLLALVGDQLIQSHHYAADAIRPRCVELRHLCDDFINGNKKKW
DILGKSLEFHRQLDKVSQWCEAGIYLLASQAVDKCQSREGVDIALNDIATFLGTVKEYPL
LSPKEFYNEFELLLTLDAKAKAQKVLQRLDDVQEIFHKRQVSLMKLAAKQTRPVQPVAPH
PESSPKWVSSKTSQPSTSVPLARPLRTSEEPYTETELNSRGKEDDETKFEVKSEEIFESH
HERGNPELEQQARLGDLSPRRRIIRDLLETEEIYIKEIKSIIDGYITPMDFIWLKHLIPD
VLQNNKDFLFGNIRELYEFHNRTFLKELEKCAENPELLAHCFLKRKEDLQIYFKYHKNLP
RARAIWQECQDCAYFGVCQRQLDHNLPLFKYLKGPSQRLIKYQMLLKGLLDFESPEDMEI
DPGELGGSAKDGPKRTKDSAFSTELQQALAVIEDLIKSCELAVDLAAVTECPDDIGKLGK
LLLHGPFSVWTIHKDRYKMKDLIRFKPSQRQIYLFERGIVFCKIRMEPGDQGLSPHYSFK
KAMKLMTLSIRQLGRGSHRKFEIASRNGLEKYILQAASKEIRDCWFSEISKLLMEQQNNI
KDQGNPQFEMSTSKGSGAGSGPWIKNMERATTSKEDPASSTGGIKGCSSREFSSMDTFED
CEGAEDMEKESSALSLAGLFQSDDSHETCSSKSAFLERGESSQGEKEERDEEETATRSTE
EERAGASTGRLAPAGATAGFQARALRPRTSAQES
GenBank ID Protein 31742505
UniProtKB/Swiss-Prot ID Q86YR7
UniProtKB/Swiss-Prot Entry Name MF2L2_HUMAN
PDB IDs Not Available
GenBank Gene ID NM_015078.2
GeneCard ID MCF2L2
GenAtlas ID MCF2L2
HGNC ID HGNC:30319
References
General References
  1. Ota T, Suzuki Y, Nishikawa T, Otsuki T, Sugiyama T, Irie R, Wakamatsu A, Hayashi K, Sato H, Nagai K, Kimura K, Makita H, Sekine M, Obayashi M, Nishi T, Shibahara T, Tanaka T, Ishii S, Yamamoto J, Saito K, Kawai Y, Isono Y, Nakamura Y, Nagahari K, Murakami K, Yasuda T, Iwayanagi T, Wagatsuma M, Shiratori A, Sudo H, Hosoiri T, Kaku Y, Kodaira H, Kondo H, Sugawara M, Takahashi M, Kanda K, Yokoi T, Furuya T, Kikkawa E, Omura Y, Abe K, Kamihara K, Katsuta N, Sato K, Tanikawa M, Yamazaki M, Ninomiya K, Ishibashi T, Yamashita H, Murakawa K, Fujimori K, Tanai H, Kimata M, Watanabe M, Hiraoka S, Chiba Y, Ishida S, Ono Y, Takiguchi S, Watanabe S, Yosida M, Hotuta T, Kusano J, Kanehori K, Takahashi-Fujii A, Hara H, Tanase TO, Nomura Y, Togiya S, Komai F, Hara R, Takeuchi K, Arita M, Imose N, Musashino K, Yuuki H, Oshima A, Sasaki N, Aotsuka S, Yoshikawa Y, Matsunawa H, Ichihara T, Shiohata N, Sano S, Moriya S, Momiyama H, Satoh N, Takami S, Terashima Y, Suzuki O, Nakagawa S, Senoh A, Mizoguchi H, Goto Y, Shimizu F, Wakebe H, Hishigaki H, Watanabe T, Sugiyama A, Takemoto M, Kawakami B, Yamazaki M, Watanabe K, Kumagai A, Itakura S, Fukuzumi Y, Fujimori Y, Komiyama M, Tashiro H, Tanigami A, Fujiwara T, Ono T, Yamada K, Fujii Y, Ozaki K, Hirao M, Ohmori Y, Kawabata A, Hikiji T, Kobatake N, Inagaki H, Ikema Y, Okamoto S, Okitani R, Kawakami T, Noguchi S, Itoh T, Shigeta K, Senba T, Matsumura K, Nakajima Y, Mizuno T, Morinaga M, Sasaki M, Togashi T, Oyama M, Hata H, Watanabe M, Komatsu T, Mizushima-Sugano J, Satoh T, Shirai Y, Takahashi Y, Nakagawa K, Okumura K, Nagase T, Nomura N, Kikuchi H, Masuho Y, Yamashita R, Nakai K, Yada T, Nakamura Y, Ohara O, Isogai T, Sugano S: Complete sequencing and characterization of 21,243 full-length human cDNAs. Nat Genet. 2004 Jan;36(1):40-5. Epub 2003 Dec 21. [PubMed:14702039 ]
  2. Gerhard DS, Wagner L, Feingold EA, Shenmen CM, Grouse LH, Schuler G, Klein SL, Old S, Rasooly R, Good P, Guyer M, Peck AM, Derge JG, Lipman D, Collins FS, Jang W, Sherry S, Feolo M, Misquitta L, Lee E, Rotmistrovsky K, Greenhut SF, Schaefer CF, Buetow K, Bonner TI, Haussler D, Kent J, Kiekhaus M, Furey T, Brent M, Prange C, Schreiber K, Shapiro N, Bhat NK, Hopkins RF, Hsie F, Driscoll T, Soares MB, Casavant TL, Scheetz TE, Brown-stein MJ, Usdin TB, Toshiyuki S, Carninci P, Piao Y, Dudekula DB, Ko MS, Kawakami K, Suzuki Y, Sugano S, Gruber CE, Smith MR, Simmons B, Moore T, Waterman R, Johnson SL, Ruan Y, Wei CL, Mathavan S, Gunaratne PH, Wu J, Garcia AM, Hulyk SW, Fuh E, Yuan Y, Sneed A, Kowis C, Hodgson A, Muzny DM, McPherson J, Gibbs RA, Fahey J, Helton E, Ketteman M, Madan A, Rodrigues S, Sanchez A, Whiting M, Madari A, Young AC, Wetherby KD, Granite SJ, Kwong PN, Brinkley CP, Pearson RL, Bouffard GG, Blakesly RW, Green ED, Dickson MC, Rodriguez AC, Grimwood J, Schmutz J, Myers RM, Butterfield YS, Griffith M, Griffith OL, Krzywinski MI, Liao N, Morin R, Palmquist D, Petrescu AS, Skalska U, Smailus DE, Stott JM, Schnerch A, Schein JE, Jones SJ, Holt RA, Baross A, Marra MA, Clifton S, Makowski KA, Bosak S, Malek J: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). Genome Res. 2004 Oct;14(10B):2121-7. [PubMed:15489334 ]
  3. Sjoblom T, Jones S, Wood LD, Parsons DW, Lin J, Barber TD, Mandelker D, Leary RJ, Ptak J, Silliman N, Szabo S, Buckhaults P, Farrell C, Meeh P, Markowitz SD, Willis J, Dawson D, Willson JK, Gazdar AF, Hartigan J, Wu L, Liu C, Parmigiani G, Park BH, Bachman KE, Papadopoulos N, Vogelstein B, Kinzler KW, Velculescu VE: The consensus coding sequences of human breast and colorectal cancers. Science. 2006 Oct 13;314(5797):268-74. Epub 2006 Sep 7. [PubMed:16959974 ]
  4. Muzny DM, Scherer SE, Kaul R, Wang J, Yu J, Sudbrak R, Buhay CJ, Chen R, Cree A, Ding Y, Dugan-Rocha S, Gill R, Gunaratne P, Harris RA, Hawes AC, Hernandez J, Hodgson AV, Hume J, Jackson A, Khan ZM, Kovar-Smith C, Lewis LR, Lozado RJ, Metzker ML, Milosavljevic A, Miner GR, Morgan MB, Nazareth LV, Scott G, Sodergren E, Song XZ, Steffen D, Wei S, Wheeler DA, Wright MW, Worley KC, Yuan Y, Zhang Z, Adams CQ, Ansari-Lari MA, Ayele M, Brown MJ, Chen G, Chen Z, Clendenning J, Clerc-Blankenburg KP, Chen R, Chen Z, Davis C, Delgado O, Dinh HH, Dong W, Draper H, Ernst S, Fu G, Gonzalez-Garay ML, Garcia DK, Gillett W, Gu J, Hao B, Haugen E, Havlak P, He X, Hennig S, Hu S, Huang W, Jackson LR, Jacob LS, Kelly SH, Kube M, Levy R, Li Z, Liu B, Liu J, Liu W, Lu J, Maheshwari M, Nguyen BV, Okwuonu GO, Palmeiri A, Pasternak S, Perez LM, Phelps KA, Plopper FJ, Qiang B, Raymond C, Rodriguez R, Saenphimmachak C, Santibanez J, Shen H, Shen Y, Subramanian S, Tabor PE, Verduzco D, Waldron L, Wang J, Wang J, Wang Q, Williams GA, Wong GK, Yao Z, Zhang J, Zhang X, Zhao G, Zhou J, Zhou Y, Nelson D, Lehrach H, Reinhardt R, Naylor SL, Yang H, Olson M, Weinstock G, Gibbs RA: The DNA sequence, annotation and analysis of human chromosome 3. Nature. 2006 Apr 27;440(7088):1194-8. [PubMed:16641997 ]
  5. Nagase T, Ishikawa K, Suyama M, Kikuno R, Hirosawa M, Miyajima N, Tanaka A, Kotani H, Nomura N, Ohara O: Prediction of the coding sequences of unidentified human genes. XII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. DNA Res. 1998 Dec 31;5(6):355-64. [PubMed:10048485 ]
  6. Takeuchi F, Ochiai Y, Serizawa M, Yanai K, Kuzuya N, Kajio H, Honjo S, Takeda N, Kaburagi Y, Yasuda K, Shirasawa S, Sasazuki T, Kato N: Search for type 2 diabetes susceptibility genes on chromosomes 1q, 3q and 12q. J Hum Genet. 2008;53(4):314-24. doi: 10.1007/s10038-008-0254-6. Epub 2008 Feb 8. [PubMed:18259684 ]