Hmdb loader
Identification
HMDB Protein ID HMDBP11503
Secondary Accession Numbers
  • 17857
Name IQ motif and SEC7 domain-containing protein 3
Synonyms Not Available
Gene Name IQSEC3
Protein Type Unknown
Biological Properties
General Function Involved in ARF guanyl-nucleotide exchange factor activity
Specific Function Acts as a guanine nucleotide exchange factor (GEF) for ARF1
Pathways Not Available
Reactions Not Available
GO Classification
Component
cell part
intracellular
Function
small gtpase regulator activity
enzyme regulator activity
arf guanyl-nucleotide exchange factor activity
nucleoside-triphosphatase regulator activity
gtpase regulator activity
Process
regulation of ras protein signal transduction
biological regulation
regulation of biological process
regulation of arf protein signal transduction
regulation of cellular process
regulation of cell communication
regulation of signal transduction
regulation of small gtpase mediated signal transduction
Cellular Location
  1. Cytoplasm
Gene Properties
Chromosome Location Chromosome:1
Locus 12p13.33
SNPs IQSEC3
Gene Sequence
>3549 bp
ATGGAGAGCCTGCTGGAGAATCCGGTGCGCGCCGTGCTCTACCTCAAGGAGCTCACGGCC
ATCGTGCAGAACCAGCAGAGCCTCATCCACACCCAGCGAGAGCGTATCGACGAGCTGGAG
CGGCGGCTGGACGAGCTGAGCGCTGAGAACCGCAGCCTGTGGGAGCACCAGCAGCTGCTG
CAAGCCCAGCCTCCGCCCGGGCTCGTCCCCCCGTCATCGGCCCCGCTGCCGGCCGCTCCG
GCCACCGCTCCTGCCGCCGCCGCCAGGGCCCAGGAACCTCTCCAGGACCAGGGACAGCGC
TCAGCAGCCGCGCCGCATCCCGCGCCCGATCGGCCGCCGCGTCAGCACCACGGACAGCTC
CTGGAGCAGCCCCAGCGGGGCCCTGGCAGCAGGGCTCACACACCCCAGTCGCCCCACAAG
CATCTGGGGACACAAGGGGCCGTGACTGACAAGGAGAAGGAGCGTCCCCCGAGTTGCTGC
GCTGCTGCCGGAGCCCTCCTTCAGCACAAATCCCCCTCCGCCCTCGGCAAGGGCGTCCTG
AGCAGGAGACCTGAGAATGAGACCGTGCTGCACCAGTTCTGCTGCCCAGCCGCCGACGCC
TGCTCCGACCTGGCCTCCCAAAGTGATGGCTCCTGCACCCAGGCCGGTGGGGGCATGGAG
GACTCCGTGGTGGCAGCGGCGGCGGTGGCAGCCGGCAGACCCAGTGCCCATGCCCCGAAG
GCTCAAGCCCAGGAGCTGCAGGAGGAGGAGGAGCGGCCGGGGGCAGGGGCTGCCTCCCCA
AGGGCTGGCCCCCAGCACAAGGCCTCCCCCGGCCGGCAGCAGCCTGCCCTGGCGACGGCG
CTGTGCCCCCACGCCCCTGCCGCCTCCGATTACGAACTCTCCCTTGACCTAAAGAATAAA
CAGATTGAAATGCTAGAACATAAGTACGGCGGTCACCTGGTGTCCCGGCGCGCCGCTTGC
ACCATCCAAACCGCCTTCCGCCAATACCAGCTCAGCAAGAACTTCGAGAAAATCCGCAAC
TCGCTTCTGGAGAGCCGCCTGCCACGGCGGATCTCCCTGCGCAAGGTGCGGTCACCCACG
GCCGAGAGCCTGGCGGCCGAGAAAGCGCTCATGGAGGGCTACGGCCTCGTGGGGCTGCCG
CTGGTGCGCTCGCCCTCCCTGCCGCCCACCTTCGCAGGCACCCTCACCGAGCTGGAGGAC
TCCTTCACCGAGCAGGTGCAATCCCTGGCCAAGTCCATCGACGACGCGCTCAGCACGTGG
AGCCTCAAGACCATGTGCTCCCTGCGGGAGAGTGGCGCTTACCAGCTCCACCAGGCCCTG
CAGGCGGCCGCGGGGCCCCCAGGCCTGGAGGCCGAGGGGCGGGCGCCGGAGAGCGCGGGC
CCCGGGCCCGGGGATGACGCCGCGGAGACCCCCGGCCTGCCCCCGGCCCACAGCGGGACC
CTCATGATGGCTTTCCGGGACGTCACGGTGCAGATCGCCAACCAGAACATATCCGTCTCC
TCCTCCACGGCTCTGTCGGTGGCCAACTGCCTGGGCGCTCAGACGGTCCAGGCCCCCGCA
GAGCCCGCGGCGGGCAAGGCCGAGCAGGGCGAGACCTCTGGGCGGGAGGCCCCGGAAGCC
CCCGCCGTGGGCCGGGAGGACGCGTCAGCCGAGGACTCATGCGCAGAGGCTGCGGCTAGT
GGGGCGGCGGATGGGGCCACAGCCCCCAAAACAGAGGAGGAAGAGGAGGAGGAGGAGACG
GCGGAGGTGGGGAGAGGGGCCGAGGCCGAGGCAGGCGACTTGGAGCAGCTGAGCAGCAGC
AGCACGTCCACCAAGTCCGCCAAGTCAGGCTCGGAGGCGTCGGCCTCCGCCTCCAAGGAC
GCCCTGCAGGCCATGATCCTGAGCCTGCCGCGCTACCACTGCGAGAACCCAGCCAGCTGC
AAGTCGCCCACGCTCTCCACCGACACCCTGCGCAAGCGGCTCTACCGCATCGGCCTCAAC
CTCTTCAACATAAACCCCGACAAGGGCATCCAGTTCCTGATCTCACGCGGCTTCATCCCG
GACACCCCCATCGGTGTGGCCCATTTCCTCCTCCAGCGAAAGGGCCTCAGCCGCCAGATG
ATTGGAGAGTTCCTGGGCAACAGCAAGAAGCAGTTCAACCGCGACGTGCTGGACTGCGTG
GTGGACGAGATGGACTTCTCCAGCATGGAGCTGGACGAGGCCCTGCGCAAGTTCCAGGCA
CACATCCGTGTGCAGGGGGAGGCTCAGAAGGTGGAGCGGCTCATTGAGGCCTTCAGCCAG
CGCTACTGCATGTGCAACCCCGAAGTGGTTCAGCAGTTCCACAACCCCGACACCATCTTC
ATCCTCGCCTTCGCCATCATCCTCCTCAACACCGACATGTACAGCCCCAACATCAAGCCT
GACCGGAAGATGATGCTGGAGGACTTCATCCGAAACCTTCGAGGTGTGGACGATGGCGCT
GACATCCCCAGGGAGCTGGTGGTAGGCATCTATGAGAGGATACAGCAGAAGGAGCTCAAG
TCCAATGAGGACCACGTCACGTACGTCACCAAGGTGGAGAAGTCCATTGTGGGCATGAAG
ACAGTGCTGTCCGTGCCCCACCGCCGCCTGGTGTGCTGCAGCCGGCTCTTCGAGGTGACG
GATGTGAACAAGCTGCAGAAGCAGGCAGCGCATCAGAGGGAGGTGTTCCTCTTCAATGAC
CTGCTGGTGATTCTCAAACTTTGCCCGAAGAAGAAGAGCTCCTCCACGTACACCTTTTGC
AAGTCAGTTGGCCTGCTGGGCATGCAGTTCCAGCTCTTTGAGAACGAGTATTACTCTCAT
GGCATCACACTGGTGACCCCGCTCTCGGGCTCCGAGAAGAAGCAGGTGCTGCATTTCTGT
GCCCTGGGCTCGGACGAGATGCAGAAGTTCGTGGAGGACCTGAAGGAGTCCATTGCTGAG
GTGACGGAGCTGGAGCAGATCCGAATAGAGTGGGAGCTGGAGAAGCAGCAGGGAACAAAG
ACACTCTCCTTCAAGCCCTGCGGAGCCCAGGGGGACCCACAGTCAAAGCAAGGATCGCCG
ACAGCCAAAAGGGAAGCCGCGCTCAGGGAGAGGCCGGCGGAGAGCACGGTGGAGGTGTCA
ATTCACAACAGGCTTCAAACGTCCCAGCACAACTCCGGGCTGGGGGCCGAGAGGGGAGCG
CCGGTGCCGCCGCCAGACCTGCAGCCTAGCCCCCCGAGACAGCAGACCCCACCACTGCCG
CCGCCGCCACCCACGCCCCCGGGCACCCTGGTGCAGTGCCAGCAAATTGTCAAGGTCATT
GTCCTGGACAAGCCCTGCCTGGCCCGCATGGAGCCCCTGCTGAGCCAGGCTCTCTCCTGC
TACACCTCGTCGTCCTCTGACTCCTGCGGCTCCACACCCCTGGGCGGTCCCGGCTCTCCG
GTCAAGGTCACCCACCAGCCTCCGCTGCCCCCGCCCCCACCCCCCTACAACCACCCTCAC
CAGTTCTGTCCCCCAGGCTCCCTGCTGCACGGGCACCGCTACTCCAGTGGCTCAAGGAGC
CTGGTGTAG
Protein Properties
Number of Residues 1182
Molecular Weight 127619.9
Theoretical pI 6.49
Pfam Domain Function
Signals
  • None
Transmembrane Regions
  • None
Protein Sequence
>IQ motif and SEC7 domain-containing protein 3
MESLLENPVRAVLYLKELTAIVQNQQSLIHTQRERIDELERRLDELSAENRSLWEHQQLL
QAQPPPGLVPPSSAPLPAAPATAPAAAARAQEPLQDQGQRSAAAPHPAPDRPPRQHHGQL
LEQPQRGPGSRAHTPQSPHKHLGTQGAVTDKEKERPPSCCAAAGALLQHKSPSALGKGVL
SRRPENETVLHQFCCPAADACSDLASQSDGSCTQAGGGMEDSVVAAAAVAAGRPSAHAPK
AQAQELQEEEERPGAGAASPRAGPQHKASPGRQQPALATALCPHAPAASDYELSLDLKNK
QIEMLEHKYGGHLVSRRAACTIQTAFRQYQLSKNFEKIRNSLLESRLPRRISLRKVRSPT
AESLAAEKALMEGYGLVGLPLVRSPSLPPTFAGTLTELEDSFTEQVQSLAKSIDDALSTW
SLKTMCSLRESGAYQLHQALQAAAGPPGLEAEGRAPESAGPGPGDDAAETPGLPPAHSGT
LMMAFRDVTVQIANQNISVSSSTALSVANCLGAQTVQAPAEPAAGKAEQGETSGREAPEA
PAVGREDASAEDSCAEAAASGAADGATAPKTEEEEEEEETAEVGRGAEAEAGDLEQLSSS
STSTKSAKSGSEASASASKDALQAMILSLPRYHCENPASCKSPTLSTDTLRKRLYRIGLN
LFNINPDKGIQFLISRGFIPDTPIGVAHFLLQRKGLSRQMIGEFLGNSKKQFNRDVLDCV
VDEMDFSSMELDEALRKFQAHIRVQGEAQKVERLIEAFSQRYCMCNPEVVQQFHNPDTIF
ILAFAIILLNTDMYSPNIKPDRKMMLEDFIRNLRGVDDGADIPRELVVGIYERIQQKELK
SNEDHVTYVTKVEKSIVGMKTVLSVPHRRLVCCSRLFEVTDVNKLQKQAAHQREVFLFND
LLVILKLCPKKKSSSTYTFCKSVGLLGMQFQLFENEYYSHGITLVTPLSGSEKKQVLHFC
ALGSDEMQKFVEDLKESIAEVTELEQIRIEWELEKQQGTKTLSFKPCGAQGDPQSKQGSP
TAKREAALRERPAESTVEVSIHNRLQTSQHNSGLGAERGAPVPPPDLQPSPPRQQTPPLP
PPPPTPPGTLVQCQQIVKVIVLDKPCLARMEPLLSQALSCYTSSSSDSCGSTPLGGPGSP
VKVTHQPPLPPPPPPYNHPHQFCPPGSLLHGHRYSSGSRSLV
GenBank ID Protein 282721018
UniProtKB/Swiss-Prot ID Q9UPP2
UniProtKB/Swiss-Prot Entry Name IQEC3_HUMAN
PDB IDs Not Available
GenBank Gene ID NM_001170738.1
GeneCard ID IQSEC3
GenAtlas ID IQSEC3
HGNC ID HGNC:29193
References
General References
  1. Ota T, Suzuki Y, Nishikawa T, Otsuki T, Sugiyama T, Irie R, Wakamatsu A, Hayashi K, Sato H, Nagai K, Kimura K, Makita H, Sekine M, Obayashi M, Nishi T, Shibahara T, Tanaka T, Ishii S, Yamamoto J, Saito K, Kawai Y, Isono Y, Nakamura Y, Nagahari K, Murakami K, Yasuda T, Iwayanagi T, Wagatsuma M, Shiratori A, Sudo H, Hosoiri T, Kaku Y, Kodaira H, Kondo H, Sugawara M, Takahashi M, Kanda K, Yokoi T, Furuya T, Kikkawa E, Omura Y, Abe K, Kamihara K, Katsuta N, Sato K, Tanikawa M, Yamazaki M, Ninomiya K, Ishibashi T, Yamashita H, Murakawa K, Fujimori K, Tanai H, Kimata M, Watanabe M, Hiraoka S, Chiba Y, Ishida S, Ono Y, Takiguchi S, Watanabe S, Yosida M, Hotuta T, Kusano J, Kanehori K, Takahashi-Fujii A, Hara H, Tanase TO, Nomura Y, Togiya S, Komai F, Hara R, Takeuchi K, Arita M, Imose N, Musashino K, Yuuki H, Oshima A, Sasaki N, Aotsuka S, Yoshikawa Y, Matsunawa H, Ichihara T, Shiohata N, Sano S, Moriya S, Momiyama H, Satoh N, Takami S, Terashima Y, Suzuki O, Nakagawa S, Senoh A, Mizoguchi H, Goto Y, Shimizu F, Wakebe H, Hishigaki H, Watanabe T, Sugiyama A, Takemoto M, Kawakami B, Yamazaki M, Watanabe K, Kumagai A, Itakura S, Fukuzumi Y, Fujimori Y, Komiyama M, Tashiro H, Tanigami A, Fujiwara T, Ono T, Yamada K, Fujii Y, Ozaki K, Hirao M, Ohmori Y, Kawabata A, Hikiji T, Kobatake N, Inagaki H, Ikema Y, Okamoto S, Okitani R, Kawakami T, Noguchi S, Itoh T, Shigeta K, Senba T, Matsumura K, Nakajima Y, Mizuno T, Morinaga M, Sasaki M, Togashi T, Oyama M, Hata H, Watanabe M, Komatsu T, Mizushima-Sugano J, Satoh T, Shirai Y, Takahashi Y, Nakagawa K, Okumura K, Nagase T, Nomura N, Kikuchi H, Masuho Y, Yamashita R, Nakai K, Yada T, Nakamura Y, Ohara O, Isogai T, Sugano S: Complete sequencing and characterization of 21,243 full-length human cDNAs. Nat Genet. 2004 Jan;36(1):40-5. Epub 2003 Dec 21. [PubMed:14702039 ]
  2. Gerhard DS, Wagner L, Feingold EA, Shenmen CM, Grouse LH, Schuler G, Klein SL, Old S, Rasooly R, Good P, Guyer M, Peck AM, Derge JG, Lipman D, Collins FS, Jang W, Sherry S, Feolo M, Misquitta L, Lee E, Rotmistrovsky K, Greenhut SF, Schaefer CF, Buetow K, Bonner TI, Haussler D, Kent J, Kiekhaus M, Furey T, Brent M, Prange C, Schreiber K, Shapiro N, Bhat NK, Hopkins RF, Hsie F, Driscoll T, Soares MB, Casavant TL, Scheetz TE, Brown-stein MJ, Usdin TB, Toshiyuki S, Carninci P, Piao Y, Dudekula DB, Ko MS, Kawakami K, Suzuki Y, Sugano S, Gruber CE, Smith MR, Simmons B, Moore T, Waterman R, Johnson SL, Ruan Y, Wei CL, Mathavan S, Gunaratne PH, Wu J, Garcia AM, Hulyk SW, Fuh E, Yuan Y, Sneed A, Kowis C, Hodgson A, Muzny DM, McPherson J, Gibbs RA, Fahey J, Helton E, Ketteman M, Madan A, Rodrigues S, Sanchez A, Whiting M, Madari A, Young AC, Wetherby KD, Granite SJ, Kwong PN, Brinkley CP, Pearson RL, Bouffard GG, Blakesly RW, Green ED, Dickson MC, Rodriguez AC, Grimwood J, Schmutz J, Myers RM, Butterfield YS, Griffith M, Griffith OL, Krzywinski MI, Liao N, Morin R, Palmquist D, Petrescu AS, Skalska U, Smailus DE, Stott JM, Schnerch A, Schein JE, Jones SJ, Holt RA, Baross A, Marra MA, Clifton S, Makowski KA, Bosak S, Malek J: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). Genome Res. 2004 Oct;14(10B):2121-7. [PubMed:15489334 ]
  3. Scherer SE, Muzny DM, Buhay CJ, Chen R, Cree A, Ding Y, Dugan-Rocha S, Gill R, Gunaratne P, Harris RA, Hawes AC, Hernandez J, Hodgson AV, Hume J, Jackson A, Khan ZM, Kovar-Smith C, Lewis LR, Lozado RJ, Metzker ML, Milosavljevic A, Miner GR, Montgomery KT, Morgan MB, Nazareth LV, Scott G, Sodergren E, Song XZ, Steffen D, Lovering RC, Wheeler DA, Worley KC, Yuan Y, Zhang Z, Adams CQ, Ansari-Lari MA, Ayele M, Brown MJ, Chen G, Chen Z, Clerc-Blankenburg KP, Davis C, Delgado O, Dinh HH, Draper H, Gonzalez-Garay ML, Havlak P, Jackson LR, Jacob LS, Kelly SH, Li L, Li Z, Liu J, Liu W, Lu J, Maheshwari M, Nguyen BV, Okwuonu GO, Pasternak S, Perez LM, Plopper FJ, Santibanez J, Shen H, Tabor PE, Verduzco D, Waldron L, Wang Q, Williams GA, Zhang J, Zhou J, Allen CC, Amin AG, Anyalebechi V, Bailey M, Barbaria JA, Bimage KE, Bryant NP, Burch PE, Burkett CE, Burrell KL, Calderon E, Cardenas V, Carter K, Casias K, Cavazos I, Cavazos SR, Ceasar H, Chacko J, Chan SN, Chavez D, Christopoulos C, Chu J, Cockrell R, Cox CD, Dang M, Dathorne SR, David R, Davis CM, Davy-Carroll L, Deshazo DR, Donlin JE, D'Souza L, Eaves KA, Egan A, Emery-Cohen AJ, Escotto M, Flagg N, Forbes LD, Gabisi AM, Garza M, Hamilton C, Henderson N, Hernandez O, Hines S, Hogues ME, Huang M, Idlebird DG, Johnson R, Jolivet A, Jones S, Kagan R, King LM, Leal B, Lebow H, Lee S, LeVan JM, Lewis LC, London P, Lorensuhewa LM, Loulseged H, Lovett DA, Lucier A, Lucier RL, Ma J, Madu RC, Mapua P, Martindale AD, Martinez E, Massey E, Mawhiney S, Meador MG, Mendez S, Mercado C, Mercado IC, Merritt CE, Miner ZL, Minja E, Mitchell T, Mohabbat F, Mohabbat K, Montgomery B, Moore N, Morris S, Munidasa M, Ngo RN, Nguyen NB, Nickerson E, Nwaokelemeh OO, Nwokenkwo S, Obregon M, Oguh M, Oragunye N, Oviedo RJ, Parish BJ, Parker DN, Parrish J, Parks KL, Paul HA, Payton BA, Perez A, Perrin W, Pickens A, Primus EL, Pu LL, Puazo M, Quiles MM, Quiroz JB, Rabata D, Reeves K, Ruiz SJ, Shao H, Sisson I, Sonaike T, Sorelle RP, Sutton AE, Svatek AF, Svetz LA, Tamerisa KS, Taylor TR, Teague B, Thomas N, Thorn RD, Trejos ZY, Trevino BK, Ukegbu ON, Urban JB, Vasquez LI, Vera VA, Villasana DM, Wang L, Ward-Moore S, Warren JT, Wei X, White F, Williamson AL, Wleczyk R, Wooden HS, Wooden SH, Yen J, Yoon L, Yoon V, Zorrilla SE, Nelson D, Kucherlapati R, Weinstock G, Gibbs RA: The finished DNA sequence of human chromosome 12. Nature. 2006 Mar 16;440(7082):346-51. [PubMed:16541075 ]
  4. Kikuno R, Nagase T, Ishikawa K, Hirosawa M, Miyajima N, Tanaka A, Kotani H, Nomura N, Ohara O: Prediction of the coding sequences of unidentified human genes. XIV. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. DNA Res. 1999 Jun 30;6(3):197-205. [PubMed:10470851 ]
  5. Hattori Y, Ohta S, Hamada K, Yamada-Okabe H, Kanemura Y, Matsuzaki Y, Okano H, Kawakami Y, Toda M: Identification of a neuron-specific human gene, KIAA1110, that is a guanine nucleotide exchange factor for ARF1. Biochem Biophys Res Commun. 2007 Dec 28;364(4):737-42. Epub 2007 Oct 15. [PubMed:17981261 ]