Hmdb loader
Identification
HMDB Protein ID HMDBP11549
Secondary Accession Numbers
  • 20993
Name HIRA-interacting protein 3
Synonyms Not Available
Gene Name HIRIP3
Protein Type Enzyme
Biological Properties
General Function Translation, ribosomal structure and biogenesis
Specific Function May play a role in chromatin function and histone metabolism via its interaction with HIRA and histones
Pathways Not Available
Reactions Not Available
GO Classification Not Available
Cellular Location
  1. Nucleus
Gene Properties
Chromosome Location Chromosome:1
Locus 16p11.2
SNPs HIRIP3
Gene Sequence
>1671 bp
ATGGCGCGGGAGAAGGAGATGCAGGAGTTCACCCGTAGCTTCTTCCGAGGCCGCCCGGAC
CTCAGCACGCTTACGCATTCCATCGTGCGGCGGAGGTACTTAGCTCACTCGGGCCGCAGC
CACCTGGAGCCCGAGGAGAAGCAGGCACTGAAGCGGCTGGTGGAGGAGGAGCTGCTGAAG
ATGCAGGTGGATGAAGCCGCTTCCAGGGAAGACAAACTGGACCTTACCAAGAAGGGCAAG
AGGCCTCCCACCCCTTGTAGCGACCCGGAGAGAAAAAGGTTCCGCTTCAATTCAGAGTCG
GAGTCCGGCTCTGAAGCCTCCAGCCCAGACTACTTTGGACCCCCAGCAAAGAATGGGGTG
GCAGCAGAAGTCAGCCCAGCCAAAGAGGAGAATCCAAGGCGAGCCTCAAAGGCAGTTGAG
GAGAGCAGTGATGAGGAACGGCAGAGGGACCTGCCCGCACAGAGGGGAGAGGAGAGCAGT
GAGGAGGAGGAAAAGGGGTACAAGGGGAAGACTAGGAAGAAACCTGTGGTAAAGAAGCAG
GCACCAGGCAAGGCCTCAGTCAGTAGGAAGCAGGCCAGGGAAGAAAGTGAGGAGAGCGAG
GCAGAACCCGTTCAGAGGACAGCAAAGAAGGTGGAGGGAAATAAAGGAACTAAAAGCCTG
AAGGAAAGTGAACAGGAGAGTGAAGAGGAGATCCTAGCCCAGAAGAAAGAGCAGAGAGAG
GAGGAAGTGGAGGAGGAAGAGAAAGAAGAGGATGAGGAAAAGGGGGATTGGAAACCCAGA
ACCAGGAGCAATGGCCGGAGAAAGTCAGCTAGGGAGGAGAGGAGCTGTAAGCAGAAAAGC
CAGGCAAAGAGGCTCTTGGGAGACTCAGACAGCGAGGAAGAGCAGAAAGAGGCAGCCAGC
AGTGGGGATGACAGTGGGAGAGATAGAGAACCCCCAGTGCAGAGGAAGAGTGAGGACAGG
ACCCAGCTTAAGGGTGGGAAGAGGTTGAGTGGAAGCAGCGAGGACGAGGAAGACAGTGGG
AAGGGGGAACCCACAGCTAAAGGCTCTAGAAAGATGGCCAGACTGGGCAGCACCAGTGGT
GAGGAAAGTGACTTGGAGAGGGAGGTAAGTGACAGCGAGGCAGGGGGAGGCCCCCAGGGG
GAGAGGAAGAACCGCTCTTCCAAGAAGAGCTCCAGGAAAGGCAGGACACGAAGCTCCTCT
TCCTCCTCAGATGGAAGTCCAGAGGCCAAAGGAGGGAAGGCTGGCTCAGGTCGCCGTGGA
GAGGACCACCCGGCTGTGATGAGGCTGAAGCGCTACATTCGGGCCTGTGGTGCCCATCGA
AACTACAAGAAGCTGTTGGGCTCCTGTTGCTCACACAAGGAGCGCCTGAGTATCCTCCGG
GCAGAACTGGAAGCGCTAGGCATGAAGGGTACCCCTTCCCTAGGGAAGTGTCGGGCCCTG
AAGGAGCAGAGGGAGGAGGCAGCTGAGGTGGCCTCCTTGGATGTTGCGAACATCATCAGT
GGCTCGGGCCGGCCACGCAGACGTACAGCCTGGAACCCTTTAGGAGAAGCAGCACCCCCA
GGGGAGCTGTACCGACGGACCCTGGACTCAGATGAAGAGCGGCCCCGTCCCGCACCCCCA
GACTGGTCACATATGCGTGGCATCATCAGCAGTGATGGCGAGAGTAACTGA
Protein Properties
Number of Residues 556
Molecular Weight 61956.5
Theoretical pI 8.9
Pfam Domain Function
Signals
  • None
Transmembrane Regions
  • None
Protein Sequence
>HIRA-interacting protein 3
MAREKEMQEFTRSFFRGRPDLSTLTHSIVRRRYLAHSGRSHLEPEEKQALKRLVEEELLK
MQVDEAASREDKLDLTKKGKRPPTPCSDPERKRFRFNSESESGSEASSPDYFGPPAKNGV
AAEVSPAKEENPRRASKAVEESSDEERQRDLPAQRGEESSEEEEKGYKGKTRKKPVVKKQ
APGKASVSRKQAREESEESEAEPVQRTAKKVEGNKGTKSLKESEQESEEEILAQKKEQRE
EEVEEEEKEEDEEKGDWKPRTRSNGRRKSAREERSCKQKSQAKRLLGDSDSEEEQKEAAS
SGDDSGRDREPPVQRKSEDRTQLKGGKRLSGSSEDEEDSGKGEPTAKGSRKMARLGSTSG
EESDLEREVSDSEAGGGPQGERKNRSSKKSSRKGRTRSSSSSSDGSPEAKGGKAGSGRRG
EDHPAVMRLKRYIRACGAHRNYKKLLGSCCSHKERLSILRAELEALGMKGTPSLGKCRAL
KEQREEAAEVASLDVANIISGSGRPRRRTAWNPLGEAAPPGELYRRTLDSDEERPRPAPP
DWSHMRGIISSDGESN
GenBank ID Protein 21396500
UniProtKB/Swiss-Prot ID Q9BW71
UniProtKB/Swiss-Prot Entry Name HIRP3_HUMAN
PDB IDs Not Available
GenBank Gene ID NM_003609.3
GeneCard ID HIRIP3
GenAtlas ID HIRIP3
HGNC ID HGNC:4917
References
General References
  1. Gerhard DS, Wagner L, Feingold EA, Shenmen CM, Grouse LH, Schuler G, Klein SL, Old S, Rasooly R, Good P, Guyer M, Peck AM, Derge JG, Lipman D, Collins FS, Jang W, Sherry S, Feolo M, Misquitta L, Lee E, Rotmistrovsky K, Greenhut SF, Schaefer CF, Buetow K, Bonner TI, Haussler D, Kent J, Kiekhaus M, Furey T, Brent M, Prange C, Schreiber K, Shapiro N, Bhat NK, Hopkins RF, Hsie F, Driscoll T, Soares MB, Casavant TL, Scheetz TE, Brown-stein MJ, Usdin TB, Toshiyuki S, Carninci P, Piao Y, Dudekula DB, Ko MS, Kawakami K, Suzuki Y, Sugano S, Gruber CE, Smith MR, Simmons B, Moore T, Waterman R, Johnson SL, Ruan Y, Wei CL, Mathavan S, Gunaratne PH, Wu J, Garcia AM, Hulyk SW, Fuh E, Yuan Y, Sneed A, Kowis C, Hodgson A, Muzny DM, McPherson J, Gibbs RA, Fahey J, Helton E, Ketteman M, Madan A, Rodrigues S, Sanchez A, Whiting M, Madari A, Young AC, Wetherby KD, Granite SJ, Kwong PN, Brinkley CP, Pearson RL, Bouffard GG, Blakesly RW, Green ED, Dickson MC, Rodriguez AC, Grimwood J, Schmutz J, Myers RM, Butterfield YS, Griffith M, Griffith OL, Krzywinski MI, Liao N, Morin R, Palmquist D, Petrescu AS, Skalska U, Smailus DE, Stott JM, Schnerch A, Schein JE, Jones SJ, Holt RA, Baross A, Marra MA, Clifton S, Makowski KA, Bosak S, Malek J: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). Genome Res. 2004 Oct;14(10B):2121-7. [PubMed:15489334 ]
  2. Dephoure N, Zhou C, Villen J, Beausoleil SA, Bakalarski CE, Elledge SJ, Gygi SP: A quantitative atlas of mitotic phosphorylation. Proc Natl Acad Sci U S A. 2008 Aug 5;105(31):10762-7. doi: 10.1073/pnas.0805139105. Epub 2008 Jul 31. [PubMed:18669648 ]
  3. Mayya V, Lundgren DH, Hwang SI, Rezaul K, Wu L, Eng JK, Rodionov V, Han DK: Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions. Sci Signal. 2009 Aug 18;2(84):ra46. doi: 10.1126/scisignal.2000007. [PubMed:19690332 ]
  4. Beausoleil SA, Jedrychowski M, Schwartz D, Elias JE, Villen J, Li J, Cohn MA, Cantley LC, Gygi SP: Large-scale characterization of HeLa cell nuclear phosphoproteins. Proc Natl Acad Sci U S A. 2004 Aug 17;101(33):12130-5. Epub 2004 Aug 9. [PubMed:15302935 ]
  5. Olsen JV, Blagoev B, Gnad F, Macek B, Kumar C, Mortensen P, Mann M: Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. Cell. 2006 Nov 3;127(3):635-48. [PubMed:17081983 ]
  6. Gauci S, Helbig AO, Slijper M, Krijgsveld J, Heck AJ, Mohammed S: Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach. Anal Chem. 2009 Jun 1;81(11):4493-501. doi: 10.1021/ac9004309. [PubMed:19413330 ]
  7. Beausoleil SA, Villen J, Gerber SA, Rush J, Gygi SP: A probability-based approach for high-throughput protein phosphorylation analysis and site localization. Nat Biotechnol. 2006 Oct;24(10):1285-92. Epub 2006 Sep 10. [PubMed:16964243 ]
  8. Molina H, Horn DM, Tang N, Mathivanan S, Pandey A: Global proteomic profiling of phosphopeptides using electron transfer dissociation tandem mass spectrometry. Proc Natl Acad Sci U S A. 2007 Feb 13;104(7):2199-204. Epub 2007 Feb 7. [PubMed:17287340 ]
  9. Tang LY, Deng N, Wang LS, Dai J, Wang ZL, Jiang XS, Li SJ, Li L, Sheng QH, Wu DQ, Li L, Zeng R: Quantitative phosphoproteome profiling of Wnt3a-mediated signaling network: indicating the involvement of ribonucleoside-diphosphate reductase M2 subunit phosphorylation at residue serine 20 in canonical Wnt signal transduction. Mol Cell Proteomics. 2007 Nov;6(11):1952-67. Epub 2007 Aug 12. [PubMed:17693683 ]
  10. Kim JE, Tannenbaum SR, White FM: Global phosphoproteome of HT-29 human colon adenocarcinoma cells. J Proteome Res. 2005 Jul-Aug;4(4):1339-46. [PubMed:16083285 ]
  11. Carrascal M, Ovelleiro D, Casas V, Gay M, Abian J: Phosphorylation analysis of primary human T lymphocytes using sequential IMAC and titanium oxide enrichment. J Proteome Res. 2008 Dec;7(12):5167-76. [PubMed:19367720 ]
  12. Lorain S, Quivy JP, Monier-Gavelle F, Scamps C, Lecluse Y, Almouzni G, Lipinski M: Core histones and HIRIP3, a novel histone-binding protein, directly interact with WD repeat protein HIRA. Mol Cell Biol. 1998 Sep;18(9):5546-56. [PubMed:9710638 ]
  13. Assrir N, Filhol O, Galisson F, Lipinski M: HIRIP3 is a nuclear phosphoprotein interacting with and phosphorylated by the serine-threonine kinase CK2. Biol Chem. 2007 Apr;388(4):391-8. [PubMed:17391060 ]