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Identification
HMDB Protein ID HMDBP11557
Secondary Accession Numbers
  • 21001
Name E3 ubiquitin-protein ligase MIB1
Synonyms
  1. DAPK-interacting protein 1
  2. DIP-1
  3. Mind bomb homolog 1
  4. Zinc finger ZZ type with ankyrin repeat domain protein 2
Gene Name MIB1
Protein Type Enzyme
Biological Properties
General Function Involved in ubiquitin-protein ligase activity
Specific Function E3 ubiquitin-protein ligase that mediates ubiquitination of Delta receptors, which act as ligands of Notch proteins. Positively regulates the Delta-mediated Notch signaling by ubiquitinating the intracellular domain of Delta, leading to endocytosis of Delta receptors. Probably mediates ubiquitination and subsequent proteasomal degradation of DAPK1, thereby antagonizing anti-apoptotic effects of DAPK1 to promote TNF- induced apoptosis
Pathways Not Available
Reactions Not Available
GO Classification
Function
ion binding
cation binding
metal ion binding
binding
catalytic activity
small conjugating protein ligase activity
transition metal ion binding
zinc ion binding
ligase activity
protein binding
ligase activity, forming carbon-nitrogen bonds
acid-amino acid ligase activity
ubiquitin-protein ligase activity
Process
metabolic process
macromolecule metabolic process
protein modification by small protein conjugation or removal
protein modification by small protein conjugation
protein ubiquitination
macromolecule modification
protein modification process
Cellular Location
  1. Cell membrane
  2. Cytoplasm
Gene Properties
Chromosome Location Chromosome:1
Locus 18q11.2
SNPs MIB1
Gene Sequence
>3021 bp
ATGAGTAACTCCCGGAATAACCGGGTGATGGTGGAAGGGGTTGGCGCTCGGGTAGTGCGC
GGCCCGGACTGGAAGTGGGGGAAGCAGGACGGCGGCGAGGGCCATGTGGGCACCGTCCGG
AGCTTCGAGAGCCCCGAGGAGGTGGTGGTAGTGTGGGACAACGGCACAGCTGCCAACTAC
CGCTGCTCCGGGGCTTACGACCTCCGCATCCTGGACAGCGCGCCCACCGGCATCAAGCAT
GATGGAACCATGTGTGATACCTGCCGCCAGCAACCAATCATTGGCATTCGATGGAAGTGT
GCAGAGTGTACAAATTATGATTTGTGCACAGTGTGTTATCATGGAGATAAACATCATTTA
AGACATCGCTTTTACCGAATTACTACACCGGGAAGTGAGAGGGTTCTGTTAGAGTCTCGT
AGGAAATCTAAGAAGATTACAGCCAGAGGAATCTTTGCAGGTGCCAGAGTGGTGCGAGGA
GTGGACTGGCAGTGGGAAGATCAAGATGGAGGAAATGGACGTAGGGGAAAGGTAACAGAA
ATCCAGGACTGGAGTGCATCAAGCCCACATAGCGCAGCATATGTCCTCTGGGATAATGGT
GCTAAGAACCTTTACAGAGTTGGCTTTGAGGGCATGTCTGATCTGAAATGTGTCCAGGAT
GCCAAGGGAGGTTCTTTCTACAGAGATCACTGCCCTGTGCTAGGTGAGCAGAATGGCAAC
AGGAATCCTGGTGGATTGCAGATTGGTGACCTGGTAAATATAGATCTCGACCTCGAAATT
GTACAGTCTTTGCAGCATGGTCATGGAGGATGGACTGATGGAATGTTTGAGACTTTAACT
ACAACTGGAACTGTTTGTGGCATTGATGAAGATCATGACATTGTAGTACAGTATCCAAGT
GGCAATAGGTGGACCTTCAATCCTGCTGTTCTCACTAAAGCGAACATTGTCCGAAGTGGA
GATGCTGCTCAGGGTGCAGAAGGAGGCACCTCGCAGTTTCAAGTGGGTGATCTTGTACAA
GTTTGTTATGACCTGGAACGAATTAAACTTCTACAAAGAGGACATGGAGAATGGGCTGAA
GCGATGCTTCCAACTTTAGGTAAAGTTGGCCGAGTACAACAGATTTATTCAGACAGTGAT
TTAAAGGTGGAAGTTTGTGGAACATCTTGGACATACAATCCAGCAGCAGTTTCCAAGGTG
GCATCTGCAGGATCAGCCATTAGCAATGCATCTGGTGAAAGACTCTCACAACTCCTGAAG
AAATTATTTGAAACCCAAGAATCTGGTGACCTCAATGAAGAATTAGTTAAGGCTGCTGCC
AATGGAGATGTTGCTAAAGTGGAAGATTTGCTTAAAAGACCAGATGTGGATGTAAATGGG
CAATGTGCTGGCCACACAGCTATGCAAGCTGCTAGTCAGAATGGACATGTTGACATTTTG
AAGTTACTTTTGAAGCAAAACGTGGATGTCGAAGCAGAGGATAAAGATGGTGATAGAGCA
GTTCACCATGCAGCTTTTGGAGATGAAGGCGCTGTTATAGAAGTACTACATCGAGGTAGT
GCTGATTTGAATGCTCGAAACAAGCGCCGACAGACACCACTTCATATTGCTGTCAATAAA
GGTCATCTTCAAGTTGTGAAGACTTTATTGGACTTTGGCTGTCATCCCAGTCTCCAGGAT
TCTGAAGGTGATACCCCTCTTCATGATGCAATAAGTAAGAAACGTGATGATATCCTAGCA
GTTCTTTTGGAAGCTGGAGCAGATGTTACCATCACAAACAATAATGGATTTAATGCTCTG
CATCATGCTGCACTAAGGGGAAATCCCAGTGCAATGCGTGTTTTACTATCTAAATTACCA
AGACCATGGATTGTGGATGAGAAGAAAGATGATGGTTATACTGCCTTACATCTGGCTGCC
CTTAATAATCACGTAGAAGTGGCTGAACTGTTGGTACATCAGGGTAATGCAAACCTGGAT
ATCCAGAATGTGAACCAACAAACTGCCCTACACCTTGCTGTTGAACGACAGCATACCCAG
ATTGTTAGGCTTTTGGTCCGTGCAGGTGCCAAGCTTGATATTCAGGATAAGGATGGGGAT
ACTCCTTTGCATGAAGCTCTAAGGCATCACACTTTGTCTCAGCTACGTCAGCTCCAAGAT
ATGCAAGATGTGGGGAAGGTGGATGCTGCCTGGGAGCCATCCAAAAACACGTTAATAATG
GGACTTGGTACCCAGGGGGCAGAGAAGAAGAGTGCAGCATCTATTGCCTGTTTCTTGGCA
GCCAATGGTGCTGACCTGAGCATTCGAAATAAGAAGGGTCAATCGCCACTTGATCTCTGT
CCTGATCCGAATCTCTGCAAAGCACTGGCAAAGTGTCATAAGGAAAAAGTCAGTGGTCAA
GTGGGTTCTCGGAGTCCTTCTATGATTAGTAATGATTCTGAAACCTTAGAAGAGTGTATG
GTGTGCTCAGATATGAAGAGAGATACTCTTTTTGGTCCATGTGGACATATTGCTACCTGT
TCTTTATGTTCTCCACGTGTCAAGAAATGCCTCATCTGTAAAGAACAGGTTCAATCCAGG
ACAAAGATTGAAGAATGTGTGGTATGCTCTGACAAGAAAGCAGCTGTTCTTTTTCAACCC
TGTGGCCACATGTGTGCTTGTGAGAACTGTGCTAACCTGATGAAAAAGTGTGTGCAGTGT
CGAGCAGTAGTTGAACGAAGAGTGCCTTTCATTATGTGCTGTGGAGGGAAAAGTTCAGAA
GATGCCACTGATGATATCTCAAGTGGGAATATTCCAGTATTACAAAAGGACAAGGATAAT
ACCAATGTCAATGCAGATGTGCAAAAGTTGCAGCAACAGTTACAAGACATTAAAGAGCAG
ACAATGTGCCCTGTGTGTCTAGATCGTCTGAAGAATATGATTTTCCTTTGTGGTCACGGA
ACCTGTCAACTCTGTGGAGACCGCATGAGTGAATGTCCTATCTGTCGCAAGGCTATTGAA
CGAAGGATTCTTTTGTATTAA
Protein Properties
Number of Residues 1006
Molecular Weight 110135.1
Theoretical pI 6.9
Pfam Domain Function
Signals
  • None
Transmembrane Regions
  • None
Protein Sequence
>E3 ubiquitin-protein ligase MIB1
MSNSRNNRVMVEGVGARVVRGPDWKWGKQDGGEGHVGTVRSFESPEEVVVVWDNGTAANY
RCSGAYDLRILDSAPTGIKHDGTMCDTCRQQPIIGIRWKCAECTNYDLCTVCYHGDKHHL
RHRFYRITTPGSERVLLESRRKSKKITARGIFAGARVVRGVDWQWEDQDGGNGRRGKVTE
IQDWSASSPHSAAYVLWDNGAKNLYRVGFEGMSDLKCVQDAKGGSFYRDHCPVLGEQNGN
RNPGGLQIGDLVNIDLDLEIVQSLQHGHGGWTDGMFETLTTTGTVCGIDEDHDIVVQYPS
GNRWTFNPAVLTKANIVRSGDAAQGAEGGTSQFQVGDLVQVCYDLERIKLLQRGHGEWAE
AMLPTLGKVGRVQQIYSDSDLKVEVCGTSWTYNPAAVSKVASAGSAISNASGERLSQLLK
KLFETQESGDLNEELVKAAANGDVAKVEDLLKRPDVDVNGQCAGHTAMQAASQNGHVDIL
KLLLKQNVDVEAEDKDGDRAVHHAAFGDEGAVIEVLHRGSADLNARNKRRQTPLHIAVNK
GHLQVVKTLLDFGCHPSLQDSEGDTPLHDAISKKRDDILAVLLEAGADVTITNNNGFNAL
HHAALRGNPSAMRVLLSKLPRPWIVDEKKDDGYTALHLAALNNHVEVAELLVHQGNANLD
IQNVNQQTALHLAVERQHTQIVRLLVRAGAKLDIQDKDGDTPLHEALRHHTLSQLRQLQD
MQDVGKVDAAWEPSKNTLIMGLGTQGAEKKSAASIACFLAANGADLSIRNKKGQSPLDLC
PDPNLCKALAKCHKEKVSGQVGSRSPSMISNDSETLEECMVCSDMKRDTLFGPCGHIATC
SLCSPRVKKCLICKEQVQSRTKIEECVVCSDKKAAVLFQPCGHMCACENCANLMKKCVQC
RAVVERRVPFIMCCGGKSSEDATDDISSGNIPVLQKDKDNTNVNADVQKLQQQLQDIKEQ
TMCPVCLDRLKNMIFLCGHGTCQLCGDRMSECPICRKAIERRILLY
GenBank ID Protein Not Available
UniProtKB/Swiss-Prot ID Q86YT6
UniProtKB/Swiss-Prot Entry Name MIB1_HUMAN
PDB IDs Not Available
GenBank Gene ID AY149908
GeneCard ID MIB1
GenAtlas ID MIB1
HGNC ID HGNC:21086
References
General References
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  2. Gerhard DS, Wagner L, Feingold EA, Shenmen CM, Grouse LH, Schuler G, Klein SL, Old S, Rasooly R, Good P, Guyer M, Peck AM, Derge JG, Lipman D, Collins FS, Jang W, Sherry S, Feolo M, Misquitta L, Lee E, Rotmistrovsky K, Greenhut SF, Schaefer CF, Buetow K, Bonner TI, Haussler D, Kent J, Kiekhaus M, Furey T, Brent M, Prange C, Schreiber K, Shapiro N, Bhat NK, Hopkins RF, Hsie F, Driscoll T, Soares MB, Casavant TL, Scheetz TE, Brown-stein MJ, Usdin TB, Toshiyuki S, Carninci P, Piao Y, Dudekula DB, Ko MS, Kawakami K, Suzuki Y, Sugano S, Gruber CE, Smith MR, Simmons B, Moore T, Waterman R, Johnson SL, Ruan Y, Wei CL, Mathavan S, Gunaratne PH, Wu J, Garcia AM, Hulyk SW, Fuh E, Yuan Y, Sneed A, Kowis C, Hodgson A, Muzny DM, McPherson J, Gibbs RA, Fahey J, Helton E, Ketteman M, Madan A, Rodrigues S, Sanchez A, Whiting M, Madari A, Young AC, Wetherby KD, Granite SJ, Kwong PN, Brinkley CP, Pearson RL, Bouffard GG, Blakesly RW, Green ED, Dickson MC, Rodriguez AC, Grimwood J, Schmutz J, Myers RM, Butterfield YS, Griffith M, Griffith OL, Krzywinski MI, Liao N, Morin R, Palmquist D, Petrescu AS, Skalska U, Smailus DE, Stott JM, Schnerch A, Schein JE, Jones SJ, Holt RA, Baross A, Marra MA, Clifton S, Makowski KA, Bosak S, Malek J: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). Genome Res. 2004 Oct;14(10B):2121-7. [PubMed:15489334 ]
  3. Bechtel S, Rosenfelder H, Duda A, Schmidt CP, Ernst U, Wellenreuther R, Mehrle A, Schuster C, Bahr A, Blocker H, Heubner D, Hoerlein A, Michel G, Wedler H, Kohrer K, Ottenwalder B, Poustka A, Wiemann S, Schupp I: The full-ORF clone resource of the German cDNA Consortium. BMC Genomics. 2007 Oct 31;8:399. [PubMed:17974005 ]
  4. Nagase T, Kikuno R, Ishikawa KI, Hirosawa M, Ohara O: Prediction of the coding sequences of unidentified human genes. XVI. The complete sequences of 150 new cDNA clones from brain which code for large proteins in vitro. DNA Res. 2000 Feb 28;7(1):65-73. [PubMed:10718198 ]
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