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Identification
HMDB Protein ID HMDBP11564
Secondary Accession Numbers
  • 21008
Name UDP-N-acetylglucosamine transferase subunit ALG13 homolog
Synonyms
  1. Asparagine-linked glycosylation 13 homolog
  2. Glycosyltransferase 28 domain-containing protein 1
Gene Name ALG13
Protein Type Enzyme
Biological Properties
General Function Involved in transferase activity, transferring hexosyl groups
Specific Function Isoform 2 may be involved in protein N-glycosylation, second step of the dolichol-linked oligosaccharide pathway.
Pathways
  • N-Glycan biosynthesis
Reactions
Uridine diphosphate-N-acetylglucosamine + N-acetyl-D-glucosaminyl-diphosphodolichol → Uridine 5'-diphosphate + N,N'-diacetylchitobiosyl-diphosphodolichol details
UDP-N-acetyl-D-glucosamine + N-Acetyl-D-glucosaminyldiphosphodolichol → UDP + N,N'-Chitobiosyldiphosphodolichol details
GO Classification
Biological Process
lipid glycosylation
dolichol-linked oligosaccharide biosynthetic process
post-translational protein modification
protein N-linked glycosylation via asparagine
Cellular Component
endoplasmic reticulum membrane
Function
binding
catalytic activity
transferase activity
transferase activity, transferring hexosyl groups
transferase activity, transferring glycosyl groups
carbohydrate binding
Molecular Function
carbohydrate binding
N-acetylglucosaminyldiphosphodolichol N-acetylglucosaminyltransferase activity
Process
lipid modification
lipid glycosylation
metabolic process
primary metabolic process
carbohydrate metabolic process
lipid metabolic process
cellular lipid metabolic process
Cellular Location
  1. Isoform 2:Endoplasmic reticulum (Probable)
Gene Properties
Chromosome Location X
Locus Xq23
SNPs ALG13
Gene Sequence
>3414 bp
ATGAAGTGCGTGTTTGTTACCGTAGGGACCACCAGCTTTGACGACCTCATTGCGTGTGTG
TCGGCGCCCGACAGTCTGCAAAAAATCGAGAGCCTTGGTTACAACCGACTTATCCTGCAA
ATTGGTAGAGGAACGGTGGTACCTGAACCCTTCAGTACTGAGTCGTTTACTCTGGATGTT
TACAGGTACAAGGATTCCTTGAAAGAAGACATTCAGAAAGCAGATCTTGTTATTAGTCAC
GCAGGTGCAGGAAGCTGTTTGGAGACTCTGGAAAAAGGAAAGCCACTCGTAGTGGTTATA
AACGAAAAGTTGATGAACAATCATCAGCTGGAACTGGCAAAGCAGCTACACAAAGAGGGT
CATCTCTTCTATTGTACCTGCAGGGTCCTGACTTGTCCTGGGCAAGCCAAGTCCATTGCT
TCTGCTCCTGGGAAGTGCCAAGATTCTGCAGCGCTGACTTCAACTGCCTTTTCAGGCCTA
GACTTTGGGCTGCTTTCCGGATACCTGCATAAGCAAGCCCTTGTTACTGCTACCCATCCT
ACCTGCACCCTGCTTTTTCCCTCTTGCCACGCTTTTTTTCCTCTCCCTCTTACCCCCACC
CTGTACAAAATGCATAAAGGATGGAAAAACTACTGCAGCCAGAAGTCTTTGAATGAGGCA
TCAATGGATGAATATTTAGGCAGCTTAGGGCTGTTTCGAAAGCTGACTGCCAAGGATGCC
TCTTGCCTCTTTCGGGCCATTTCGGAGCAGTTGTTTTGCAGCCAGGTCCATCATTTGGAA
ATCAGGAAGGCTTGTGTCTCATATATGAGGGAAAATCAACAAACTTTTGAGTCTTATGTG
GAGGGATCTTTTGAGAAATACCTGGAACGGTTGGGAGATCCCAAGGAAAGTGCTGGCCAG
CTGGAAATAAGAGCTCTTTCTCTAATTTATAATCGGGATTTCATTCTTTATCGCTTTCCT
GGAAAACCTCCAACTTATGTCACAGATAATGGCTATGAAGACAAGATTCTACTCTGCTAC
TCAAGTAGTGGTCACTATGATTCTGTGTACTCAAAACAATTTCAGTCAAGTGCAGCTGTT
TGTCAGGCTGTATTGTACGAAATTCTCTATAAAGATGTGTTTGTTGTGGATGAAGAAGAG
TTGAAGACTGCGATTAAATTGTTTCGAAGTGGTTCTAAGAAGAACAGAAATAATGCTGTA
ACTGGAAGCGAGGATGCCCATACTGATTACAAGAGTTCAAATCAGAATAGGATGGAAGAG
TGGGGTGCCTGCTACAATGCTGAAAATATACCAGAGGGCTACAATAAAGGAACAGAAGAA
ACAAAGTCTCCAGAAAATCCATCAAAGATGCCCTTCCCCTATAAGGTGCTCAAAGCCCTG
GATCCAGAAATCTATCGTAATGTAGAATTTGATGTTTGGTTGGACAGCAGAAAAGAACTT
CAAAAATCTGATTACATGGAGTATGCTGGGAGACAGTACTATTTGGGAGACAAGTGTCAG
GTTTGCTTGGAATCAGAAGGAAGATATTATAATGCTCATATCCAGGAAGTTGGAAATGAG
AACAATTCAGTAACAGTCTTCATTGAAGAATTGGCGGAAAAGCATGTTGTTCCACTGGCT
AACTTAAAACCAGTTACCCAAGTGATGTCTGTTCCTGCCTGGAATGCTATGCCCAGTCGG
AAAGGAAGAGGTTACCAGAAAATGCCTGGGGGTTATGTCCCGGAAATAGTTATATCAGAG
ATGGACATAAAGCAACAGAAGAAGATGTTCAAGAAAATTCGAGGGAAAGAAGTTTACATG
ACTATGGCTTACGGCAAGGGAGACCCCCTCCTCCCACCCAGGCTGCAGCACAGTATGCAT
TATGGGCACGATCCTCCAATGCACTACTCACAGACAGCTGGCAATGTTATGTCTAATGAA
CATTTTCATCCTCAGCATCCATCTCCGAGACAAGGTCGGGGATATGGGATGCCCAGGAAT
TCATCTCGGTTTATAAACAGGCACAACATGCCGGGCCCTAAAGTTGATTTTTACCCAGGC
CCAGGTAAAAGGTGCTGCCAGAGCTATGATAACTTCTCTTATAGATCTCGTTCATTTAGA
CGTAGTCACCGCCAGATGAGTTGTGTGAATAAGGAGTCCCAGTATGGATTTACCCCAGGG
AATGGACAGATGCCCAGGGGCTTGGAAGAAACTATTACTTTTTATGAAGTTGAAGAAGGG
GATGAGACTGCTTATCCAACTTTACCTAATCATGGAGGTCCCTCTACAATGGTTCCTGCT
ACTTCAGGATACTGTGTTGGAAGGCGGGGACATAGCTCAGGCAAACAGACTTTGAATTTA
GAGGAGGGCAATGGCCAGAGTGAAAATGGGCGATATCATGAAGAATATCTTTATCGTGCA
GAGCCAGACTATGAAACTTCAGGTGTTTATAGCACAACTGCATCTACAGCAAACTTGTCT
CTTCAGGACAGAAAGTCATGTTCTATGTCTCCTCAGGACACAGTTACCTCATACAACTAC
CCCCAGAAGATGATGGGAAATATTGCAGCAGTTGCAGCTTCCTGTGCCAATAATGTTCCA
GCTCCAGTCTTATCTAACGGTGCAGCGGCTAATCAAGCTATTAGTACCACTTCAGTTTCC
TCACAGAATGCTATACAGCCTCTCTTTGTATCTCCACCTACACACGGCAGGCCAGTGATT
GCCTCACCATCCTATCCATGCCATTCTGCTATTCCTCATGCTGGTGCCTCTCTACCACCA
CCACCACCACCACCACCACCACCACCACCACCACCACCTCCTCCTCCTCCTCCTCCTCCT
CCTCCTCCTCCTCCTGCTCTTGATGTGGGAGAGACTTCAAACTTACAACCACCACCACCA
CTACCACCTCCACCTTATTCCTGTGATCCAAGCGGCAGTGATTTGCCTCAAGATACAAAA
GTTTTGCAGTACTATTTCAATCTAGGATTGCAGTGCTATTACCACAGCTACTGGCACTCC
ATGGTCTATGTGCCACAGATGCAGCAGCAGCTTCATGTAGAGAATTATCCAGTCTATACT
GAGCCACCTCTGGTAGATCAAACCGTTCCTCAATGCTACAGTGAGGTGAGGAGAGAAGAT
GGCATACAGGCGGAAGCATCAGCAAATGATACTTTTCCGAATGCTGATTCTTCATCTGTC
CCTCATGGAGCAGTCTATTATCCAGTAATGTCAGATCCCTATGGGCAGCCACCTTTGCCA
GGTTTTGACTCCTGCCTTCCGGTTGTGCCAGATTATTCCTGTGTTCCCCCCTGGCATCCA
GTTGGTACAGCATATGGTGGTTCTTCTCAAATTCATGGTGCTATAAATCCTGGGCCAATT
GGCTGTATTGCTCCATCTCCCCCAGCTTCTCATTATGTACCTCAGGGTATGTAA
Protein Properties
Number of Residues 1137
Molecular Weight 15149.285
Theoretical pI 9.375
Pfam Domain Function
Signals Not Available
Transmembrane Regions Not Available
Protein Sequence
>UDP-N-acetylglucosamine transferase subunit ALG13 homolog
MKCVFVTVGTTSFDDLIACVSAPDSLQKIESLGYNRLILQIGRGTVVPEPFSTESFTLDV
YRYKDSLKEDIQKADLVISHAGAGSCLETLEKGKPLVVVINEKLMNNHQLELAKQLHKEG
HLFYCTCRVLTCPGQAKSIASAPGKCQDSAALTSTAFSGLDFGLLSGYLHKQALVTATHP
TCTLLFPSCHAFFPLPLTPTLYKMHKGWKNYCSQKSLNEASMDEYLGSLGLFRKLTAKDA
SCLFRAISEQLFCSQVHHLEIRKACVSYMRENQQTFESYVEGSFEKYLERLGDPKESAGQ
LEIRALSLIYNRDFILYRFPGKPPTYVTDNGYEDKILLCYSSSGHYDSVYSKQFQSSAAV
CQAVLYEILYKDVFVVDEEELKTAIKLFRSGSKKNRNNAVTGSEDAHTDYKSSNQNRMEE
WGACYNAENIPEGYNKGTEETKSPENPSKMPFPYKVLKALDPEIYRNVEFDVWLDSRKEL
QKSDYMEYAGRQYYLGDKCQVCLESEGRYYNAHIQEVGNENNSVTVFIEELAEKHVVPLA
NLKPVTQVMSVPAWNAMPSRKGRGYQKMPGGYVPEIVISEMDIKQQKKMFKKIRGKEVYM
TMAYGKGDPLLPPRLQHSMHYGHDPPMHYSQTAGNVMSNEHFHPQHPSPRQGRGYGMPRN
SSRFINRHNMPGPKVDFYPGPGKRCCQSYDNFSYRSRSFRRSHRQMSCVNKESQYGFTPG
NGQMPRGLEETITFYEVEEGDETAYPTLPNHGGPSTMVPATSGYCVGRRGHSSGKQTLNL
EEGNGQSENGRYHEEYLYRAEPDYETSGVYSTTASTANLSLQDRKSCSMSPQDTVTSYNY
PQKMMGNIAAVAASCANNVPAPVLSNGAAANQAISTTSVSSQNAIQPLFVSPPTHGRPVI
ASPSYPCHSAIPHAGASLPPPPPPPPPPPPPPPPPPPPPPPPPPPALDVGETSNLQPPPP
LPPPPYSCDPSGSDLPQDTKVLQYYFNLGLQCYYHSYWHSMVYVPQMQQQLHVENYPVYT
EPPLVDQTVPQCYSEVRREDGIQAEASANDTFPNADSSSVPHGAVYYPVMSDPYGQPPLP
GFDSCLPVVPDYSCVPPWHPVGTAYGGSSQIHGAINPGPIGCIAPSPPASHYVPQGM
GenBank ID Protein 153791910
UniProtKB/Swiss-Prot ID Q9NP73
UniProtKB/Swiss-Prot Entry Name ALG13_HUMAN
PDB IDs Not Available
GenBank Gene ID NM_001099922.2
GeneCard ID ALG13
GenAtlas ID ALG13
HGNC ID HGNC:30881
References
General References
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