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Identification
HMDB Protein ID HMDBP11565
Secondary Accession Numbers
  • 21009
Name L-aminoadipate-semialdehyde dehydrogenase-phosphopantetheinyl transferase
Synonyms
  1. 4'-phosphopantetheinyl transferase
  2. AASD-PPT
  3. Alpha-aminoadipic semialdehyde dehydrogenase-phosphopantetheinyl transferase
  4. LYS5 ortholog
Gene Name AASDHPPT
Protein Type Enzyme
Biological Properties
General Function Involved in magnesium ion binding
Specific Function Catalyzes the post-translational modification of target proteins by phosphopantetheine. Can transfer the 4'-phosphopantetheine moiety from coenzyme A to a serine residue of a broad range of acceptors, such as the acyl carrier domain of FASN.
Pathways
  • Pantothenate and CoA biosynthesis
Reactions
CoA-[4'-phosphopantetheine] + apo-[acyl-carrier-protein] → Adenosine 3',5'-diphosphate + holo-[acyl-carrier-protein] details
Coenzyme A + Apo-[acyl-carrier-protein] → Adenosine 3',5'-diphosphate + Acyl-carrier protein details
GO Classification
Biological Process
macromolecule biosynthetic process
pantothenate metabolic process
Cellular Component
cytosol
Function
ion binding
cation binding
metal ion binding
binding
catalytic activity
transferase activity
transferase activity, transferring phosphorus-containing groups
magnesium ion binding
phosphotransferase activity, for other substituted phosphate groups
holo-[acyl-carrier-protein] synthase activity
Molecular Function
magnesium ion binding
holo-[acyl-carrier-protein] synthase activity
Process
macromolecule biosynthetic process
metabolic process
biosynthetic process
Cellular Location
  1. Cytoplasm
Gene Properties
Chromosome Location 11
Locus 11q22
SNPs AASDHPPT
Gene Sequence
>930 bp
ATGGTTTTCCCTGCCAAACGGTTCTGCTTGGTGCCATCCATGGAGGGCGTGCGCTGGGCC
TTTTCCTGCGGCACTTGGCTGCCGAGCCGAGCCGAATGGCTGCTGGCAGTGCGATCGATT
CAGCCCGAGGAGAAGGAGCGCATTGGCCAGTTCGTCTTTGCCCGGGACGCTAAGGCAGCC
ATGGCTGGTCGTCTGATGATAAGGAAATTAGTTGCAGAGAAATTGAATATCCCTTGGAAT
CATATTCGTTTGCAAAGAACTGCAAAAGGAAAACCAGTTCTTGCAAAGGACTCATCGAAT
CCATACCCGAATTTCAACTTTAACATCTCTCATCAAGGAGACTATGCAGTGCTTGCTGCT
GAACCTGAGCTGCAAGTTGGAATTGATATAATGAAGACTAGTTTTCCAGGTCGTGGTTCA
ATTCCAGAATTCTTTCATATTATGAAAAGAAAGTTTACCAACAAAGAATGGGAAACAATC
AGAAGCTTTAAGGATGAGTGGACTCAGCTGGATATGTTTTATAGGAATTGGGCACTTAAG
GAAAGCTTCATAAAAGCCATTGGTGTTGGACTAGGATTTGAATTGCAGCGGCTTGAATTT
GATCTATCTCCATTAAACTTGGATATAGGCCAAGTTTATAAAGAAACACGTTTATTCCTG
GATGGAGAGGAAGAAAAAGAATGGGCATTTGAGGAAAGCAAAATAGATGAGCACCATTTT
GTTGCAGTTGCTCTTAGGAAACCCGACGGATCTAGACATCAGGATGTTCCATCTCAGGAT
GATTCCAAACCAACCCAGAGGCAATTTACTATTCTCAACTTTAATGATTTAATGTCATCT
GCCGTTCCCATGACACCTGAAGATCCTTCATTTTGGGACTGTTTTTGCTTCACAGAAGAA
ATTCCAATACGAAATGGTACAAAGTCATGA
Protein Properties
Number of Residues 309
Molecular Weight 35775.64
Theoretical pI 6.805
Pfam Domain Function
Signals Not Available
Transmembrane Regions Not Available
Protein Sequence
>L-aminoadipate-semialdehyde dehydrogenase-phosphopantetheinyl transferase
MVFPAKRFCLVPSMEGVRWAFSCGTWLPSRAEWLLAVRSIQPEEKERIGQFVFARDAKAA
MAGRLMIRKLVAEKLNIPWNHIRLQRTAKGKPVLAKDSSNPYPNFNFNISHQGDYAVLAA
EPELQVGIDIMKTSFPGRGSIPEFFHIMKRKFTNKEWETIRSFKDEWTQLDMFYRNWALK
ESFIKAIGVGLGFELQRLEFDLSPLNLDIGQVYKETRLFLDGEEEKEWAFEESKIDEHHF
VAVALRKPDGSRHQDVPSQDDSKPTQRQFTILNFNDLMSSAVPMTPEDPSFWDCFCFTEE
IPIRNGTKS
GenBank ID Protein Not Available
UniProtKB/Swiss-Prot ID Q9NRN7
UniProtKB/Swiss-Prot Entry Name ADPPT_HUMAN
PDB IDs
GenBank Gene ID AF302110
GeneCard ID AASDHPPT
GenAtlas ID AASDHPPT
HGNC ID HGNC:14235
References
General References
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