Hmdb loader
Identification
HMDB Protein ID HMDBP11588
Secondary Accession Numbers
  • 21032
Name S-acyl fatty acid synthase thioesterase, medium chain
Synonyms
  1. Oleoyl-ACP hydrolase
  2. Thioesterase II
  3. Thioesterase domain-containing protein 1
  4. Augmented in rheumatoid arthritis 1
  5. AURA1
Gene Name OLAH
Protein Type Enzyme
Biological Properties
General Function Involved in biosynthetic process
Specific Function In fatty acid biosynthesis chain termination and release of the free fatty acid product is achieved by hydrolysis of the thio ester by a thioesterase I, a component of the fatty acid synthetase complex. The chain length of the released fatty acid is usually C16. However, in the mammary glands of non-ruminant mammals, and in the uropygial gland of certain waterfowl there exists a second thioesterase which releases medium-chain length fatty acids (C8 to C2) (By similarity).
Pathways
  • fatty acid biosynthesis
Reactions
Oleoyl-[acyl-carrier-protein] + Water → [acyl-carrier-protein] + Oleic acid details
Hexadecanoyl-[acp] + Water → Acyl-carrier protein + Palmitic acid details
Oleoyl-[acyl-carrier protein] + Water → Acyl-carrier protein + Oleic acid details
Dodecanoyl-[acyl-carrier protein] + Water → Acyl-carrier protein + Dodecanoic acid details
Tetradecanoyl-[acp] + Water → Acyl-carrier protein + Myristic acid details
Octadecanoyl-[acyl-carrier protein] + Water → Acyl-carrier protein + Stearic acid details
GO Classification
Biological Process
fatty acid biosynthetic process
Function
hydrolase activity, acting on ester bonds
catalytic activity
hydrolase activity
Molecular Function
myristoyl-[acyl-carrier-protein] hydrolase activity
oleoyl-[acyl-carrier-protein] hydrolase activity
palmitoyl-[acyl-carrier-protein] hydrolase activity
Process
metabolic process
biosynthetic process
Cellular Location
  1. Cytoplasmic
Gene Properties
Chromosome Location 10
Locus 10p13
SNPs OLAH
Gene Sequence
>798 bp
ATGGAGAGAGGAGACCAACCTAAGAGAACCAGGAATGAAAACATTTTCAACTGCTTATAC
AAAAACCCTGAGGCAACTTTTAAGCTGATTTGCTTTCCCTGGATGGGAGGTGGCTCCACT
CATTTTGCCAAATGGGGCCAAGATACTCATGATTTGCTGGAAGTGCACTCCTTAAGGCTT
CCTGGAAGAGAAAGCAGAGTTGAAGAACCTCTTGAAAATGACATCTCCCAGTTAGTTGAT
GAAGTTGTTTGTGCTCTGCAGCCAGTCATCCAGGATAAACCATTTGCATTTTTTGGCCAC
AGTATGGGATCCTACATTGCTTTTAGGACTGCACTAGGTCTAAAAGAAAACAATCAACCA
GAACCATTGCATTTATTTTTGTCAAGTGCAACTCCTGTACATTCAAAGGCCTGGCATCGC
ATTCCCAAAGATGATGAATTGTCAGAAGAACAAATAAGTCATTACCTTATGGAATTTGGA
GGCACCCCCAAGCATTTTGCTGAAGCCAAGGAATTTGTGAAACAATGTAGTCCCATCATA
AGGGCAGATCTGAACATTGTTAGAAGTTGCACCTCTAACGTACCATCTAAGGCTGTTCTT
TCCTGTGACTTGACATGTTTTGTTGGATCTGAAGACATAGCAAAGGACATGGAAGCCTGG
AAAGATGTAACCAGTGGAAATGCTAAAATTTACCAGCTTCCAGGGGGTCACTTTTATCTT
CTGGATCCTGCGAACGAGAAATTAATCAAGAACTACATAATCAAGTGTCTAGAAGTATCA
TCGATATCCAATTTTTAG
Protein Properties
Number of Residues 265
Molecular Weight 29930.82
Theoretical pI 6.223
Pfam Domain Function
Signals Not Available
Transmembrane Regions Not Available
Protein Sequence
>S-acyl fatty acid synthase thioesterase, medium chain
MERGDQPKRTRNENIFNCLYKNPEATFKLICFPWMGGGSTHFAKWGQDTHDLLEVHSLRL
PGRESRVEEPLENDISQLVDEVVCALQPVIQDKPFAFFGHSMGSYIAFRTALGLKENNQP
EPLHLFLSSATPVHSKAWHRIPKDDELSEEQISHYLMEFGGTPKHFAEAKEFVKQCSPII
RADLNIVRSCTSNVPSKAVLSCDLTCFVGSEDIAKDMEAWKDVTSGNAKIYQLPGGHFYL
LDPANEKLIKNYIIKCLEVSSISNF
GenBank ID Protein 7023364
UniProtKB/Swiss-Prot ID Q9NV23
UniProtKB/Swiss-Prot Entry Name SAST_HUMAN
PDB IDs Not Available
GenBank Gene ID AK001844
GeneCard ID OLAH
GenAtlas ID OLAH
HGNC ID HGNC:25625
References
General References
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