| Identification |
|---|
| HMDB Protein ID
| HMDBP11616 |
| Secondary Accession Numbers
| None |
| Name
| Protein arginine N-methyltransferase 6 |
| Synonyms
|
- Heterogeneous nuclear ribonucleoprotein methyltransferase-like protein 6
- Histone-arginine N-methyltransferase PRMT6
|
| Gene Name
| PRMT6 |
| Protein Type
| Unknown |
| Biological Properties |
|---|
| General Function
| Not Available |
| Specific Function
| Arginine methyltransferase that can both catalyze the formation of omega-N monomethylarginine (MMA) and asymmetrical dimethylarginine (aDMA), with a strong preference for the formation of aDMA. Preferentially methylates arginyl residues present in a glycine and arginine-rich domain and displays preference for monomethylated substrates. Specifically mediates the asymmetric dimethylation of histone H3 'Arg-2' to form H3R2me2a. H3R2me2a represents a specific tag for epigenetic transcriptional repression and is mutually exclusive with methylation on histone H3 'Lys-4' (H3K4me2 and H3K4me3). It thereby acts as a transcription corepressor of various genes such as HOXA2. Also methylates histone H2A and H4 'Arg-3' (H2AR3me and H4R3me, respectively). Acts as a regulator of DNA base excision during DNA repair by mediating the methylation of DNA polymerase beta (POLB), leading to stimulate the polymerase activity by enhancing DNA binding and processivity. Methylates HMGA1. May play a role in innate immunity against HIV-1 in case of infection by methylating and impairing the function of various HIV-1 proteins such as Tat, Rev and Nucleocapsid protein p7 (NC).
|
| Pathways
|
Not Available
|
| Reactions
|
| S-Adenosylmethionine + arginine-[histone] → S-Adenosylhomocysteine + N(omega)-methyl-arginine-[histone] |
details
|
|
| GO Classification
|
| Biological Process |
| negative regulation of transcription, DNA-dependent |
| virus-host interaction |
| base-excision repair |
| transcription, DNA-dependent |
| Cellular Component |
| nucleus |
| Molecular Function |
| histone methyltransferase activity (H4-R3 specific) |
| histone binding |
| histone methyltransferase activity (H2A-R3 specific) |
| histone methyltransferase activity (H3-R2 specific) |
| protein-arginine omega-N asymmetric methyltransferase activity |
| protein-arginine omega-N monomethyltransferase activity |
|
| Cellular Location
|
Not Available
|
| Gene Properties |
|---|
| Chromosome Location
| 1 |
| Locus
| 1p13.3 |
| SNPs
| Not Available |
| Gene Sequence
|
Not Available
|
| Protein Properties |
|---|
| Number of Residues
| Not Available |
| Molecular Weight
| 41937.22 |
| Theoretical pI
| 5.436 |
| Pfam Domain Function
|
Not Available |
| Signals
|
Not Available
|
|
Transmembrane Regions
|
Not Available
|
| Protein Sequence
|
>>gi|227908867|ref|NP_060607.2| protein arginine N-methyltransferase 6 [Homo sapiens]
MSQPKKRKLESGGGGEGGEGTEEEDGAEREAALERPRRTKRERDQLYYECYSDVSVHEEM
IADRVRTDAY
|
| External Links |
|---|
| GenBank ID Protein
| Not Available |
| UniProtKB/Swiss-Prot ID
| Q96LA8 |
| UniProtKB/Swiss-Prot Entry Name
| Not Available |
| PDB IDs
|
|
| GenBank Gene ID
| Not Available |
| GeneCard ID
| Not Available |
| GenAtlas ID
| Not Available |
| HGNC ID
| HGNC:18241 |
| References |
|---|
| General References
| Not Available |
