Identification |
HMDB Protein ID
| HMDBP11626 |
Secondary Accession Numbers
| None |
Name
| ATPase family AAA domain-containing protein 2 |
Synonyms
|
- AAA nuclear coregulator cancer-associated protein
- ANCCA
|
Gene Name
| ATAD2 |
Protein Type
| Unknown |
Biological Properties |
General Function
| Not Available |
Specific Function
| May be a transcriptional coactivator of the nuclear receptor ESR1 required to induce the expression of a subset of estradiol target genes, such as CCND1, MYC and E2F1. May play a role in the recruitment or occupancy of CREBBP at some ESR1 target gene promoters. May be required for histone hyperacetylation. Involved in the estrogen-induced cell proliferation and cell cycle progression of breast cancer cells.
|
Pathways
|
Not Available
|
Reactions
|
Adenosine triphosphate + Water → ADP + Phosphate |
details
|
|
GO Classification
|
Biological Process |
ATP catabolic process |
regulation of transcription, DNA-dependent |
transcription, DNA-dependent |
Cellular Component |
nucleus |
Molecular Function |
ATP binding |
ATPase activity |
|
Cellular Location
|
Not Available
|
Gene Properties |
Chromosome Location
| 8 |
Locus
| 8q24.13 |
SNPs
| Not Available |
Gene Sequence
|
Not Available
|
Protein Properties |
Number of Residues
| Not Available |
Molecular Weight
| 158552.525 |
Theoretical pI
| 6.32 |
Pfam Domain Function
|
Not Available |
Signals
|
Not Available
|
Transmembrane Regions
|
Not Available
|
Protein Sequence
|
>>gi|24497618|ref|NP_054828.2| ATPase family AAA domain-containing protein 2 [Homo sapiens]
MVVLRSSLELHNHSAASATGSLDLSSDFLSLEHIGRRRLRSAGAAQKKPAATTAKAGDGS
SVKEVETYHR
|
External Links |
GenBank ID Protein
| Not Available |
UniProtKB/Swiss-Prot ID
| Q6PL18 |
UniProtKB/Swiss-Prot Entry Name
| Not Available |
PDB IDs
|
|
GenBank Gene ID
| Not Available |
GeneCard ID
| Not Available |
GenAtlas ID
| Not Available |
HGNC ID
| HGNC:30123 |
References |
General References
| Not Available |