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Identification
HMDB Protein ID HMDBP11638
Secondary Accession Numbers None
Name Chromodomain-helicase-DNA-binding protein 1
Synonyms
  1. CHD-1
  2. ATP-dependent helicase CHD1
Gene Name CHD1
Protein Type Unknown
Biological Properties
General Function Not Available
Specific Function ATP-dependent chromatin-remodeling factor which functions as substrate recognition component of the transcription regulatory histone acetylation (HAT) complex SAGA. Regulates polymerase II transcription. Also required for efficient transcription by RNA polymerase I, and more specifically the polymerase I transcription termination step. Regulates negatively DNA replication. Not only involved in transcription-related chromatin-remodeling, but also required to maintain a specific chromatin configuration across the genome. Is also associated with histone deacetylase (HDAC) activity (By similarity). Required for the bridging of SNF2, the FACT complex, the PAF complex as well as the U2 snRNP complex to H3K4me3. Functions to modulate the efficiency of pre-mRNA splicing in part through physical bridging of spliceosomal components to H3K4me3. Required for maintaining open chromatin and pluripotency in embryonic stem cells.
Pathways Not Available
Reactions
Adenosine triphosphate + Water → ADP + Phosphate details
GO Classification
Biological Process
chromatin remodeling
regulation of transcription from RNA polymerase II promoter
transcription, DNA-dependent
Cellular Component
cytoplasm
nucleus
Molecular Function
ATP binding
ATP-dependent DNA helicase activity
methylated histone residue binding
DNA binding
Cellular Location Not Available
Gene Properties
Chromosome Location 5
Locus 5q15-q21
SNPs Not Available
Gene Sequence Not Available
Protein Properties
Number of Residues Not Available
Molecular Weight 196685.865
Theoretical pI 7.133
Pfam Domain Function
Signals Not Available
Transmembrane Regions Not Available
Protein Sequence
>>gi|68299795|ref|NP_001261.2| chromodomain-helicase-DNA-binding protein 1 [Homo sapiens]
MNGHSDEESVRNSSGESSQSDDDSGSASGSGSGSSSGSSSDGSSSQSGSSDSDSGSESGS
QSESESDTSR
GenBank ID Protein Not Available
UniProtKB/Swiss-Prot ID O14646
UniProtKB/Swiss-Prot Entry Name Not Available
PDB IDs
GenBank Gene ID Not Available
GeneCard ID Not Available
GenAtlas ID Not Available
HGNC ID HGNC:1915
References
General References Not Available