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HMDB Protein ID HMDBP11640
Secondary Accession Numbers None
Name Chromodomain-helicase-DNA-binding protein 3
  1. CHD-3
  2. ATP-dependent helicase CHD3
  3. Mi-2 autoantigen 240 kDa protein
  4. Mi2-alpha
  5. Zinc finger helicase
  6. hZFH
Gene Name CHD3
Protein Type Unknown
Biological Properties
General Function Not Available
Specific Function Component of the histone deacetylase NuRD complex which participates in the remodeling of chromatin by deacetylating histones. Required for anchoring centrosomal pericentrin in both interphase and mitosis, for spindle organization and centrosome integrity.
Pathways Not Available
Adenosine triphosphate + Water → ADP + Phosphate details
GO Classification
Biological Process
regulation of transcription from RNA polymerase II promoter
centrosome organization
chromatin modification
spindle organization
transcription, DNA-dependent
Cellular Component
intermediate filament cytoskeleton
NuRD complex
Molecular Function
metal ion binding
ATP binding
ATP-dependent DNA helicase activity
zinc ion binding
DNA binding
Cellular Location Not Available
Gene Properties
Chromosome Location 17
Locus 17p13.1
SNPs Not Available
Gene Sequence Not Available
Protein Properties
Number of Residues Not Available
Molecular Weight 233035.1
Theoretical pI 6.222
Pfam Domain Function
Signals Not Available
Transmembrane Regions Not Available
Protein Sequence
>>gi|158420731|ref|NP_001005271.2| chromodomain-helicase-DNA-binding protein 3 isoform 3 [Homo sapiens]
GenBank ID Protein Not Available
UniProtKB/Swiss-Prot ID Q12873
UniProtKB/Swiss-Prot Entry Name Not Available
PDB IDs Not Available
GenBank Gene ID Not Available
GeneCard ID Not Available
GenAtlas ID Not Available
General References Not Available