| Identification |
|---|
| HMDB Protein ID
| HMDBP11640 |
| Secondary Accession Numbers
| None |
| Name
| Chromodomain-helicase-DNA-binding protein 3 |
| Synonyms
|
- CHD-3
- ATP-dependent helicase CHD3
- Mi-2 autoantigen 240 kDa protein
- Mi2-alpha
- Zinc finger helicase
- hZFH
|
| Gene Name
| CHD3 |
| Protein Type
| Unknown |
| Biological Properties |
|---|
| General Function
| Not Available |
| Specific Function
| Component of the histone deacetylase NuRD complex which participates in the remodeling of chromatin by deacetylating histones. Required for anchoring centrosomal pericentrin in both interphase and mitosis, for spindle organization and centrosome integrity.
|
| Pathways
|
Not Available
|
| Reactions
|
| Adenosine triphosphate + Water → ADP + Phosphate |
details
|
|
| GO Classification
|
| Biological Process |
| regulation of transcription from RNA polymerase II promoter |
| centrosome organization |
| chromatin modification |
| spindle organization |
| transcription, DNA-dependent |
| Cellular Component |
| centrosome |
| cytoplasm |
| nucleolus |
| intermediate filament cytoskeleton |
| NuRD complex |
| Molecular Function |
| metal ion binding |
| ATP binding |
| ATP-dependent DNA helicase activity |
| zinc ion binding |
| DNA binding |
|
| Cellular Location
|
Not Available
|
| Gene Properties |
|---|
| Chromosome Location
| 17 |
| Locus
| 17p13.1 |
| SNPs
| Not Available |
| Gene Sequence
|
Not Available
|
| Protein Properties |
|---|
| Number of Residues
| Not Available |
| Molecular Weight
| 233035.1 |
| Theoretical pI
| 6.222 |
| Pfam Domain Function
|
|
| Signals
|
Not Available
|
|
Transmembrane Regions
|
Not Available
|
| Protein Sequence
|
>>gi|158420731|ref|NP_001005271.2| chromodomain-helicase-DNA-binding protein 3 isoform 3 [Homo sapiens]
MASPLRDEEEEEEEMVVSEEEEEEEEEGDEEEEEEVEAADEDDEEDDDEGVLGRGPGHDR
GRDRHSPPGC
|
| External Links |
|---|
| GenBank ID Protein
| Not Available |
| UniProtKB/Swiss-Prot ID
| Q12873 |
| UniProtKB/Swiss-Prot Entry Name
| Not Available |
| PDB IDs
|
Not Available |
| GenBank Gene ID
| Not Available |
| GeneCard ID
| Not Available |
| GenAtlas ID
| Not Available |
| HGNC ID
| HGNC:1918 |
| References |
|---|
| General References
| Not Available |
