Hmdb loader
HMDB Protein ID HMDBP11659
Secondary Accession Numbers None
Name Probable ATP-dependent RNA helicase DDX11
  1. CHL1-related protein 1
  2. DEAD/H box protein 11
  3. Keratinocyte growth factor-regulated gene 2 protein
  4. hCHLR1
  5. KRG-2
Gene Name DDX11
Protein Type Unknown
Biological Properties
General Function Not Available
Specific Function DNA helicase involved in cellular proliferation. Possesses DNA-dependent ATPase and helicase activities. This helicase translocates on single-stranded DNA in the 5' to 3' direction in the presence of ATP and, to a lesser extent, dATP. Its unwinding activity requires a 5'-single-stranded region for helicase loading, since flush-ended duplex structures do not support unwinding. The helicase activity is capable of displacing duplex regions up to 100 bp, which can be extended to 500 bp by RPA or the cohesion establishment factor, the Ctf18-RFC (replication factor C) complex activities. Stimulates the flap endonuclease activity of FEN1. Required for normal sister chromatid cohesion. Required for recruitment of bovine papillomavirus type 1 regulatory protein E2 to mitotic chrmosomes and for viral genome maintenance. Required for maintaining the chromosome segregation and is essential for embryonic development and the prevention of aneuploidy. May function during either S, G2, or M phase of the cell cycle. Binds to both single- and double-stranded DNA.
Pathways Not Available
Adenosine triphosphate + Water → ADP + Phosphate details
GO Classification
Biological Process
positive regulation of cell proliferation
G2/M transition of mitotic cell cycle
mitotic sister chromatid segregation
S phase of mitotic cell cycle
sister chromatid cohesion
virus-host interaction
activation of signaling protein activity involved in unfolded protein response
Cellular Component
nuclear chromatin
spindle pole
Molecular Function
metal ion binding
ATP binding
4 iron, 4 sulfur cluster binding
ATP-dependent DNA helicase activity
RNA binding
DNA-dependent ATPase activity
DNA helicase activity
DNA binding
Cellular Location Not Available
Gene Properties
Chromosome Location 12
Locus 12p11
SNPs Not Available
Gene Sequence Not Available
Protein Properties
Number of Residues Not Available
Molecular Weight 108312.075
Theoretical pI 7.313
Pfam Domain Function Not Available
Signals Not Available
Transmembrane Regions Not Available
Protein Sequence
>>gi|380420356|ref|NP_001244073.1| probable ATP-dependent RNA helicase DDX11 isoform 3 [Homo sapiens]
GenBank ID Protein Not Available
UniProtKB/Swiss-Prot ID Q96FC9
UniProtKB/Swiss-Prot Entry Name Not Available
PDB IDs Not Available
GenBank Gene ID Not Available
GeneCard ID Not Available
GenAtlas ID Not Available
General References Not Available