| Identification |
|---|
| HMDB Protein ID
| HMDBP11661 |
| Secondary Accession Numbers
| None |
| Name
| Probable ATP-dependent RNA helicase DDX17 |
| Synonyms
|
- DEAD box protein 17
- DEAD box protein p72
- RNA-dependent helicase p72
|
| Gene Name
| DDX17 |
| Protein Type
| Unknown |
| Biological Properties |
|---|
| General Function
| Not Available |
| Specific Function
| RNA-dependent ATPase activity. Involved in transcriptional regulation. Transcriptional coactivator for estrogen receptor ESR1. Increases ESR1 AF-1 domain-mediated transactivation. Synergizes with DDX5 and SRA1 RNA to activate MYOD1 transcriptional activity and probably involved in skeletal muscle differentiation. Required for zinc-finger antiviral protein ZC3HAV1-mediated mRNA degradation.
|
| Pathways
|
Not Available
|
| Reactions
|
| Adenosine triphosphate + Water → ADP + Phosphate |
details
|
|
| GO Classification
|
| Biological Process |
| positive regulation of intracellular estrogen receptor signaling pathway |
| regulation of skeletal muscle cell differentiation |
| RNA processing |
| positive regulation of transcription from RNA polymerase II promoter |
| transcription, DNA-dependent |
| Cellular Component |
| nucleolus |
| nucleus |
| Molecular Function |
| RNA helicase activity |
| RNA-dependent ATPase activity |
| ATP binding |
| ATP-dependent helicase activity |
| estrogen receptor binding |
| transcription coactivator activity |
| RNA binding |
|
| Cellular Location
|
Not Available
|
| Gene Properties |
|---|
| Chromosome Location
| 22 |
| Locus
| 22q13.1 |
| SNPs
| Not Available |
| Gene Sequence
|
Not Available
|
| Protein Properties |
|---|
| Number of Residues
| Not Available |
| Molecular Weight
| 80271.8 |
| Theoretical pI
| 8.269 |
| Pfam Domain Function
|
Not Available |
| Signals
|
Not Available
|
|
Transmembrane Regions
|
Not Available
|
| Protein Sequence
|
>>gi|38201710|ref|NP_006377.2| probable ATP-dependent RNA helicase DDX17 isoform 1 [Homo sapiens]
MPTGFVAPILCVLLPSPTREAATVASATGDSASERESAAPAAAPTAEAPPPSVVTRPEPQ
ALPSPAIRAP
|
| External Links |
|---|
| GenBank ID Protein
| Not Available |
| UniProtKB/Swiss-Prot ID
| Q92841 |
| UniProtKB/Swiss-Prot Entry Name
| Not Available |
| PDB IDs
|
Not Available |
| GenBank Gene ID
| Not Available |
| GeneCard ID
| Not Available |
| GenAtlas ID
| Not Available |
| HGNC ID
| HGNC:2740 |
| References |
|---|
| General References
| Not Available |
