Identification |
HMDB Protein ID
| HMDBP11730 |
Secondary Accession Numbers
| None |
Name
| Elongation of very long chain fatty acids protein 7 |
Synonyms
|
- 3-keto acyl-CoA synthase ELOVL7
- ELOVL fatty acid elongase 7
- Very-long-chain 3-oxoacyl-CoA synthase 7
- ELOVL FA elongase 7
|
Gene Name
| ELOVL7 |
Protein Type
| Unknown |
Biological Properties |
General Function
| Not Available |
Specific Function
| Condensing enzyme that catalyzes the synthesis of saturated and polyunsaturated very long chain fatty acids. Highest activity toward C18 acyl-CoAs, especially C18:3(n-3) acyl-CoAs and C18:3(n-6)-CoAs. Also active toward C20:4-, C18:0-, C18:1-, C18:2- and C16:0-CoAs, and weakly toward C20:0-CoA. Little or no activity toward C22:0-, C24:0-, or C26:0-CoAs.
|
Pathways
|
|
Reactions
|
A very-long-chain acyl-CoA + Malonyl-CoA → Coenzyme A + a very-long-chain 3-oxoacyl-CoA + CO(2) |
details
|
Malonyl-CoA + Acyl-CoA → 3-Oxoacyl-CoA + Coenzyme A + Carbon dioxide |
details
|
|
GO Classification
|
Biological Process |
fatty acid elongation, saturated fatty acid |
very long-chain fatty acid biosynthetic process |
fatty acid elongation, polyunsaturated fatty acid |
long-chain fatty-acyl-CoA biosynthetic process |
triglyceride biosynthetic process |
Cellular Component |
endoplasmic reticulum membrane |
integral to membrane |
Molecular Function |
transferase activity |
|
Cellular Location
|
Not Available
|
Gene Properties |
Chromosome Location
| 5 |
Locus
| 5q12.1 |
SNPs
| Not Available |
Gene Sequence
|
Not Available
|
Protein Properties |
Number of Residues
| Not Available |
Molecular Weight
| 33356.06 |
Theoretical pI
| 9.266 |
Pfam Domain Function
|
Not Available |
Signals
|
Not Available
|
Transmembrane Regions
|
Not Available
|
Protein Sequence
|
>>gi|157388949|ref|NP_001098028.1| elongation of very long chain fatty acids protein 7 [Homo sapiens]
MAFSDLTSRTVHLYDNWIKDADPRVEDWLLMSSPLPQTILLGFYVYFVTSLGPKLMENRK
PFELKKAMIT
|
External Links |
GenBank ID Protein
| Not Available |
UniProtKB/Swiss-Prot ID
| A1L3X0 |
UniProtKB/Swiss-Prot Entry Name
| Not Available |
PDB IDs
|
Not Available |
GenBank Gene ID
| Not Available |
GeneCard ID
| Not Available |
GenAtlas ID
| Not Available |
HGNC ID
| HGNC:26292 |
References |
General References
| Not Available |