Hmdb loader
Identification
HMDB Protein ID HMDBP11737
Secondary Accession Numbers None
Name Adenosine monophosphate-protein transferase FICD
Synonyms
  1. AMPylator FICD
  2. FIC domain-containing protein
  3. Huntingtin yeast partner E
  4. Huntingtin-interacting protein 13
  5. Huntingtin-interacting protein E
  6. HIP-13
Gene Name FICD
Protein Type Unknown
Biological Properties
General Function Not Available
Specific Function Adenylyltransferase that mediates the addition of adenosine 5'-monophosphate (AMP) to specific residues of target proteins. Able to inactivate Rho GTPases in vitro by adding AMP to RhoA, Rac and Cdc42. It is however unclear whether it inactivates GTPases in vivo and physiological substrates probably remain to be identified.
Pathways Not Available
Reactions
Adenosine triphosphate + [protein] → Pyrophosphate + [protein]-AMP details
GO Classification
Biological Process
negative regulation of Rho GTPase activity
Cellular Component
integral to membrane
Molecular Function
ATP binding
protein adenylyltransferase activity
Cellular Location Not Available
Gene Properties
Chromosome Location 12
Locus 12q24.1
SNPs Not Available
Gene Sequence Not Available
Protein Properties
Number of Residues Not Available
Molecular Weight 51777.595
Theoretical pI 7.719
Pfam Domain Function
Signals Not Available
Transmembrane Regions Not Available
Protein Sequence
>>gi|42794620|ref|NP_009007.2| adenosine monophosphate-protein transferase FICD [Homo sapiens]
MMLIPMASVMAVTEPKWVSVWSRFLWVTLLSMVLGSLLALLLPLGAVEEQCLAVLKGLYL
LRSKPDRAQH
GenBank ID Protein Not Available
UniProtKB/Swiss-Prot ID Q9BVA6
UniProtKB/Swiss-Prot Entry Name Not Available
PDB IDs Not Available
GenBank Gene ID Not Available
GeneCard ID Not Available
GenAtlas ID Not Available
HGNC ID HGNC:18416
References
General References Not Available