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Identification
HMDB Protein ID HMDBP11773
Secondary Accession Numbers None
Name Very-long-chain (3R)-3-hydroxyacyl-[acyl-carrier protein] dehydratase 1
Synonyms
  1. 3-hydroxyacyl-CoA dehydratase 1
  2. Cementum attachment protein
  3. Protein-tyrosine phosphatase-like member A
  4. HACD1
Gene Name PTPLA
Protein Type Unknown
Biological Properties
General Function Not Available
Specific Function Responsible for the dehydration step in very long-chain fatty acid (VLCFA) synthesis.
Pathways
  • Biosynthesis of unsaturated fatty acids
  • Fatty acid elongation
Reactions
A very-long-chain (3R)-3-hydroxyacyl-[acyl-carrier protein] → a very-long-chain trans-2,3-dehydroacyl-[acyl-carrier protein] + Water details
GO Classification
Biological Process
multicellular organismal development
signal transduction
fatty acid biosynthetic process
Cellular Component
endoplasmic reticulum membrane
integral to membrane
Molecular Function
lyase activity
protein tyrosine phosphatase activity
Cellular Location Not Available
Gene Properties
Chromosome Location 10
Locus 10p14-p13
SNPs Not Available
Gene Sequence Not Available
Protein Properties
Number of Residues Not Available
Molecular Weight 32387.485
Theoretical pI 9.035
Pfam Domain Function Not Available
Signals Not Available
Transmembrane Regions Not Available
Protein Sequence
>>gi|82659105|ref|NP_055056.3| very-long-chain (3R)-3-hydroxyacyl-[acyl-carrier protein] dehydratase 1 [Homo sapiens]
MGRLTEAAAAGSGSRAAGWAGSPPTLLPLSPTSPRCAATMASSDEDGTNGGASEAGEDRE
APGERRRLGV
GenBank ID Protein Not Available
UniProtKB/Swiss-Prot ID B0YJ81
UniProtKB/Swiss-Prot Entry Name Not Available
PDB IDs Not Available
GenBank Gene ID Not Available
GeneCard ID Not Available
GenAtlas ID Not Available
HGNC ID HGNC:9639
References
General References Not Available