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Identification
HMDB Protein ID HMDBP11774
Secondary Accession Numbers None
Name Very-long-chain (3R)-3-hydroxyacyl-[acyl-carrier protein] dehydratase 2
Synonyms
  1. 3-hydroxyacyl-CoA dehydratase 2
  2. Protein-tyrosine phosphatase-like member B
  3. HACD2
Gene Name PTPLB
Protein Type Unknown
Biological Properties
General Function Not Available
Specific Function Responsible for the dehydration step in very long-chain fatty acid (VLCFA) synthesis.
Pathways
  • Biosynthesis of unsaturated fatty acids
  • Fatty acid elongation
Reactions
A very-long-chain (3R)-3-hydroxyacyl-[acyl-carrier protein] → a very-long-chain trans-2,3-dehydroacyl-[acyl-carrier protein] + Water details
GO Classification
Biological Process
fatty acid biosynthetic process
Cellular Component
endoplasmic reticulum membrane
integral to membrane
Molecular Function
lyase activity
Cellular Location Not Available
Gene Properties
Chromosome Location 3
Locus 3q21.1
SNPs Not Available
Gene Sequence Not Available
Protein Properties
Number of Residues Not Available
Molecular Weight 28368.145
Theoretical pI 9.548
Pfam Domain Function Not Available
Signals Not Available
Transmembrane Regions Not Available
Protein Sequence
>>gi|38257153|ref|NP_940684.1| very-long-chain (3R)-3-hydroxyacyl-[acyl-carrier protein] dehydratase 2 [Homo sapiens]
MAAVAATAAAKGNGGGGGRAGAGDASGTRKKKGPGPLATAYLVIYNVVMTAGWLVIAVGL
VRAYLAKGSY
GenBank ID Protein Not Available
UniProtKB/Swiss-Prot ID Q6Y1H2
UniProtKB/Swiss-Prot Entry Name Not Available
PDB IDs Not Available
GenBank Gene ID Not Available
GeneCard ID Not Available
GenAtlas ID Not Available
HGNC ID HGNC:9640
References
General References Not Available