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Identification
HMDB Protein ID HMDBP11803
Secondary Accession Numbers None
Name Lysine-specific demethylase 8
Synonyms
  1. JmjC domain-containing protein 5
  2. Jumonji domain-containing protein 5
Gene Name KDM8
Protein Type Unknown
Biological Properties
General Function Not Available
Specific Function Histone demethylase required for G2/M phase cell cycle progression. Specifically demethylates dimethylated 'Lys-36' (H3K36me2) of histone H3, an epigenetic repressive mark, thereby acting as a transcription activator. Regulates expression of CCNA1 (cyclin-A1), leading to regulate cancer cell proliferation.
Pathways Not Available
Reactions
Protein N(6),N(6)-dimethyl-L-lysine + Oxoglutaric acid + Oxygen → protein N(6)-methyl-L-lysine + Succinic acid + Formaldehyde + CO(2) details
Protein N(6)-methyl-L-lysine + Oxoglutaric acid + Oxygen → protein L-lysine + Succinic acid + Formaldehyde + CO(2) details
GO Classification
Biological Process
G2/M transition of mitotic cell cycle
positive regulation of transcription, DNA-dependent
transcription, DNA-dependent
Cellular Component
nucleus
Molecular Function
metal ion binding
oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen
chromatin binding
histone demethylase activity (H3-K36 specific)
Cellular Location Not Available
Gene Properties
Chromosome Location 16
Locus 16p12.1
SNPs Not Available
Gene Sequence Not Available
Protein Properties
Number of Residues Not Available
Molecular Weight 50851.565
Theoretical pI 5.702
Pfam Domain Function Not Available
Signals Not Available
Transmembrane Regions Not Available
Protein Sequence
>>gi|223942018|ref|NP_001138820.1| lysine-specific demethylase 8 isoform 1 [Homo sapiens]
MSREKCSPGEGAEEGRGSEASGLKASAGHGTEPAGGGPMAGDTHCPAEPLAREGTLWEAL
RALLPHSKED
GenBank ID Protein Not Available
UniProtKB/Swiss-Prot ID Q8N371
UniProtKB/Swiss-Prot Entry Name Not Available
PDB IDs
GenBank Gene ID Not Available
GeneCard ID Not Available
GenAtlas ID Not Available
HGNC ID HGNC:25840
References
General References Not Available