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Identification
HMDB Protein ID HMDBP11813
Secondary Accession Numbers None
Name Lysophospholipid acyltransferase 1
Synonyms
  1. LPLAT 1
  2. 1-acylglycerophosphoserine O-acyltransferase
  3. Lysophosphatidylserine acyltransferase
  4. Membrane-bound O-acyltransferase domain-containing protein 1
  5. LPSAT
  6. Lyso-PS acyltransferase
  7. O-acyltransferase domain-containing protein 1
Gene Name MBOAT1
Protein Type Unknown
Biological Properties
General Function Not Available
Specific Function Acyltransferase which mediates the conversion of lysophosphatidylserine (1-acyl-2-hydroxy-sn-glycero-3-phospho-L-serine or LPS) into phosphatidylserine (1,2-diacyl-sn-glycero-3-phospho-L-serine or PS) (LPSAT activity). Prefers oleoyl-CoA as the acyl donor. Lysophospholipid acyltransferases (LPLATs) catalyze the reacylation step of the phospholipid remodeling pathway also known as the Lands cycle.
Pathways
  • Glycerolipid metabolism
  • Glycerophospholipid metabolism
  • phospholipid metabolism
Reactions
Acyl-CoA + 1-acyl-sn-glycero-3-phosphatidylserine → Coenzyme A + 1,2-diacyl-sn-glycero-3-phosphatidylserine details
GO Classification
Biological Process
phosphatidylethanolamine acyl-chain remodeling
phosphatidylserine acyl-chain remodeling
glycerophospholipid biosynthetic process
Cellular Component
endoplasmic reticulum membrane
integral to membrane
Molecular Function
transferase activity, transferring acyl groups other than amino-acyl groups
Cellular Location Not Available
Gene Properties
Chromosome Location 6
Locus 6p22.3
SNPs Not Available
Gene Sequence Not Available
Protein Properties
Number of Residues Not Available
Molecular Weight 56556.85
Theoretical pI 9.234
Pfam Domain Function Not Available
Signals Not Available
Transmembrane Regions Not Available
Protein Sequence
>>gi|122937404|ref|NP_001073949.1| lysophospholipid acyltransferase 1 [Homo sapiens]
MAAEPQPSSLSYRTTGSTYLHPLSELLGIPLDQVNFVVCQLVALFAAFWFRIYLRPGTTS
SDVRHAVATI
GenBank ID Protein Not Available
UniProtKB/Swiss-Prot ID Q6ZNC8
UniProtKB/Swiss-Prot Entry Name Not Available
PDB IDs Not Available
GenBank Gene ID Not Available
GeneCard ID Not Available
GenAtlas ID Not Available
HGNC ID HGNC:21579
References
General References Not Available