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Identification
HMDB Protein ID HMDBP11816
Secondary Accession Numbers None
Name DNA replication licensing factor MCM2
Synonyms
  1. Minichromosome maintenance protein 2 homolog
  2. Nuclear protein BM28
Gene Name MCM2
Protein Type Unknown
Biological Properties
General Function Not Available
Specific Function Acts as component of the MCM2-7 complex (MCM complex) which is the putative replicative helicase essential for 'once per cell cycle' DNA replication initiation and elongation in eukaryotic cells. The active ATPase sites in the MCM2-7 ring are formed through the interaction surfaces of two neighboring subunits such that a critical structure of a conserved arginine finger motif is provided in trans relative to the ATP-binding site of the Walker A box of the adjacent subunit. The six ATPase active sites, however, are likely to contribute differentially to the complex helicase activity. Required for the entry in S phase and for cell division.
Pathways
  • Cell cycle
  • DNA replication
Reactions
Adenosine triphosphate + Water → ADP + Phosphate details
GO Classification
Biological Process
S phase of mitotic cell cycle
G1/S transition of mitotic cell cycle
cell cycle checkpoint
DNA strand elongation involved in DNA replication
DNA replication initiation
M/G1 transition of mitotic cell cycle
DNA unwinding involved in replication
nucleosome assembly
Cellular Component
nucleoplasm
chromatin
MCM complex
nuclear origin of replication recognition complex
Molecular Function
metal ion binding
ATP binding
DNA replication origin binding
DNA binding
helicase activity
Cellular Location Not Available
Gene Properties
Chromosome Location 3
Locus 3q21
SNPs Not Available
Gene Sequence Not Available
Protein Properties
Number of Residues Not Available
Molecular Weight 101895.155
Theoretical pI 5.513
Pfam Domain Function
Signals Not Available
Transmembrane Regions Not Available
Protein Sequence
>>gi|33356547|ref|NP_004517.2| DNA replication licensing factor MCM2 [Homo sapiens]
MAESSESFTMASSPAQRRRGNDPLTSSPGRSSRRTDALTSSPGRDLPPFEDESEGLLGTE
GPLEEEEDGE
GenBank ID Protein Not Available
UniProtKB/Swiss-Prot ID P49736
UniProtKB/Swiss-Prot Entry Name Not Available
PDB IDs Not Available
GenBank Gene ID Not Available
GeneCard ID Not Available
GenAtlas ID Not Available
HGNC ID HGNC:6944
References
General References Not Available