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Identification
HMDB Protein ID HMDBP11840
Secondary Accession Numbers None
Name Methylthioribose-1-phosphate isomerase
Synonyms
  1. M1Pi
  2. MTR-1-P isomerase
  3. Mediator of RhoA-dependent invasion
  4. S-methyl-5-thioribose-1-phosphate isomerase
  5. Translation initiation factor eIF-2B subunit alpha/beta/delta-like protein
Gene Name MRI1
Protein Type Unknown
Biological Properties
General Function Not Available
Specific Function Catalyzes the interconversion of methylthioribose-1-phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1-P). Independently from catalytic activity, promotes cell invasion in response to constitutive RhoA activation by promoting FAK tyrosine phosphorylation and stress fiber turnover.
Pathways
  • Cysteine and methionine metabolism
  • L-methionine biosynthesis via salvage pathway
Reactions
5-Methylthioribose 1-phosphate → 5-Methylthioribulose 1-phosphate details
GO Classification
Biological Process
L-methionine salvage from methylthioadenosine
polyamine metabolic process
Cellular Component
cytosol
cell projection
nucleus
Molecular Function
S-methyl-5-thioribose-1-phosphate isomerase activity
Cellular Location Not Available
Gene Properties
Chromosome Location 19
Locus 19p13.2
SNPs Not Available
Gene Sequence Not Available
Protein Properties
Number of Residues Not Available
Molecular Weight 39149.38
Theoretical pI 6.297
Pfam Domain Function Not Available
Signals Not Available
Transmembrane Regions Not Available
Protein Sequence
>>gi|72534748|ref|NP_001026897.1| methylthioribose-1-phosphate isomerase isoform 1 [Homo sapiens]
MTLEAIRYSRGSLQILDQLLLPKQSRYEAVGSVHQAWEAIRAMKVRGAPAIALVGCLSLA
VELQAGAGGP
GenBank ID Protein Not Available
UniProtKB/Swiss-Prot ID Q9BV20
UniProtKB/Swiss-Prot Entry Name Not Available
PDB IDs Not Available
GenBank Gene ID Not Available
GeneCard ID Not Available
GenAtlas ID Not Available
HGNC ID HGNC:28469
References
General References Not Available