| Identification |
|---|
| HMDB Protein ID
| HMDBP11863 |
| Secondary Accession Numbers
| None |
| Name
| ATP-dependent (S)-NAD(P)H-hydrate dehydratase |
| Synonyms
|
- ATP-dependent NAD(P)HX dehydratase
- Carbohydrate kinase domain-containing protein
|
| Gene Name
| CARKD |
| Protein Type
| Unknown |
| Biological Properties |
|---|
| General Function
| Not Available |
| Specific Function
| Catalyzes the dehydration of the S-form of NAD(P)HX at the expense of ATP, which is converted to ADP. Together with NAD(P)HX epimerase, which catalyzes the epimerization of the S- and R-forms, the enzyme allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration (By similarity).
|
| Pathways
|
Not Available
|
| Reactions
|
| Adenosine triphosphate + (6S)-6-beta-hydroxy-1,4,5,6-tetrahydronicotinamide-adenine dinucleotide → ADP + Phosphate + NADH |
details
|
| Adenosine triphosphate + (6S)-6-beta-hydroxy-1,4,5,6-tetrahydronicotinamide-adenine dinucleotide phosphate → ADP + Phosphate + NADPH |
details
|
|
| GO Classification
|
| Cellular Component |
| mitochondrion |
| Molecular Function |
| ATP binding |
| ATP-dependent NAD(P)H-hydrate dehydratase activity |
|
| Cellular Location
|
Not Available
|
| Gene Properties |
|---|
| Chromosome Location
| 13 |
| Locus
| 13q34 |
| SNPs
| Not Available |
| Gene Sequence
|
Not Available
|
| Protein Properties |
|---|
| Number of Residues
| Not Available |
| Molecular Weight
| 36575.67 |
| Theoretical pI
| 8.055 |
| Pfam Domain Function
|
|
| Signals
|
Not Available
|
|
Transmembrane Regions
|
Not Available
|
| Protein Sequence
|
>>gi|338968897|ref|NP_001229810.1| ATP-dependent (S)-NAD(P)H-hydrate dehydratase isoform b [Homo sapiens]
MVTRAGAGTAVAGAVVVALLSAALALYGPPLDAVLERAFSLRKAHSIKDMENTLQLVRNI
IPPLSSTKHK
|
| External Links |
|---|
| GenBank ID Protein
| Not Available |
| UniProtKB/Swiss-Prot ID
| Q8IW45 |
| UniProtKB/Swiss-Prot Entry Name
| Not Available |
| PDB IDs
|
Not Available |
| GenBank Gene ID
| Not Available |
| GeneCard ID
| Not Available |
| GenAtlas ID
| Not Available |
| HGNC ID
| HGNC:25576 |
| References |
|---|
| General References
| Not Available |
