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Identification
HMDB Protein ID HMDBP11863
Secondary Accession Numbers None
Name ATP-dependent (S)-NAD(P)H-hydrate dehydratase
Synonyms
  1. ATP-dependent NAD(P)HX dehydratase
  2. Carbohydrate kinase domain-containing protein
Gene Name CARKD
Protein Type Unknown
Biological Properties
General Function Not Available
Specific Function Catalyzes the dehydration of the S-form of NAD(P)HX at the expense of ATP, which is converted to ADP. Together with NAD(P)HX epimerase, which catalyzes the epimerization of the S- and R-forms, the enzyme allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration (By similarity).
Pathways Not Available
Reactions
Adenosine triphosphate + (6S)-6-beta-hydroxy-1,4,5,6-tetrahydronicotinamide-adenine dinucleotide → ADP + Phosphate + NADH details
Adenosine triphosphate + (6S)-6-beta-hydroxy-1,4,5,6-tetrahydronicotinamide-adenine dinucleotide phosphate → ADP + Phosphate + NADPH details
GO Classification
Cellular Component
mitochondrion
Molecular Function
ATP binding
ATP-dependent NAD(P)H-hydrate dehydratase activity
Cellular Location Not Available
Gene Properties
Chromosome Location 13
Locus 13q34
SNPs Not Available
Gene Sequence Not Available
Protein Properties
Number of Residues Not Available
Molecular Weight 36575.67
Theoretical pI 8.055
Pfam Domain Function
Signals Not Available
Transmembrane Regions Not Available
Protein Sequence
>>gi|338968897|ref|NP_001229810.1| ATP-dependent (S)-NAD(P)H-hydrate dehydratase isoform b [Homo sapiens]
MVTRAGAGTAVAGAVVVALLSAALALYGPPLDAVLERAFSLRKAHSIKDMENTLQLVRNI
IPPLSSTKHK
GenBank ID Protein Not Available
UniProtKB/Swiss-Prot ID Q8IW45
UniProtKB/Swiss-Prot Entry Name Not Available
PDB IDs Not Available
GenBank Gene ID Not Available
GeneCard ID Not Available
GenAtlas ID Not Available
HGNC ID HGNC:25576
References
General References Not Available