Human Metabolome Database: Showing Protein DNA-directed RNA polymerase II subunit RPB4 (HMDBP11921)

Identification Biological properties Gene properties Protein properties External links References XML Show 5 metabolites

Identification

HMDB Protein ID

HMDBP11921

Secondary Accession Numbers

None

Name

DNA-directed RNA polymerase II subunit RPB4

Synonyms

RNA polymerase II subunit B4
DNA-directed RNA polymerase II subunit D
RNA polymerase II 16 kDa subunit
RPB16

Gene Name

POLR2D

Protein Type

Unknown

Biological Properties

General Function

Not Available

Specific Function

DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Component of RNA polymerase II which synthesizes mRNA precursors and many functional non-coding RNAs. Pol II is the central component of the basal RNA polymerase II transcription machinery. It is composed of mobile elements that move relative to each other. RPB4 is part of a subcomplex with RPB7 that binds to a pocket formed by RPB1, RPB2 and RPB6 at the base of the clamp element. The RBP4-RPB7 subcomplex seems to lock the clamp via RPB7 in the closed conformation thus preventing double stranded DNA to enter the active site cleft. The RPB4-RPB7 subcomplex binds single-stranded DNA and RNA (By similarity).

Pathways

Epstein-Barr virus infection
Huntington disease
Purine metabolism
Pyrimidine metabolism
RNA polymerase

Reactions

Adenosine triphosphate + RNA → Pyrophosphate + RNA	details
Guanosine triphosphate + RNA → Pyrophosphate + RNA	details
Cytidine triphosphate + RNA → Pyrophosphate + RNA	details
Uridine triphosphate + RNA → Pyrophosphate + RNA	details

GO Classification

Biological Process
transcription-coupled nucleotide-excision repair
7-methylguanosine mRNA capping
mRNA splicing, via spliceosome
viral reproduction
protein phosphorylation
positive regulation of viral transcription
transcription elongation from RNA polymerase II promoter
transcription initiation from RNA polymerase II promoter
Cellular Component
DNA-directed RNA polymerase II, core complex
Molecular Function
DNA-directed RNA polymerase activity
nucleotide binding

Cellular Location

Not Available

Gene Properties

Chromosome Location

Locus

2q21

SNPs

Not Available

Gene Sequence

Not Available

Protein Properties

Number of Residues

Not Available

Molecular Weight

16311.105

Theoretical pI

4.795

Pfam Domain Function

Not Available

Signals

Not Available

Transmembrane Regions

Not Available

Protein Sequence

>>gi|4758574|ref|NP_004796.1| DNA-directed RNA polymerase II subunit RPB4 [Homo sapiens]
MAAGGSDPRAGDVEEDASQLIFPKEFETAETLLNSEVHMLLEHRKQQNESAEDEQELSEV
FMKTLNYTAR

External Links

GenBank ID Protein

Not Available

UniProtKB/Swiss-Prot ID

O15514

UniProtKB/Swiss-Prot Entry Name

Not Available

PDB IDs