| Identification |
|---|
| HMDB Protein ID
| HMDBP11924 |
| Secondary Accession Numbers
| None |
| Name
| DNA-directed RNA polymerase III subunit RPC3 |
| Synonyms
|
- RNA polymerase III subunit C3
- DNA-directed RNA polymerase III subunit C
- RNA polymerase III 62 kDa subunit
- RPC62
|
| Gene Name
| POLR3C |
| Protein Type
| Unknown |
| Biological Properties |
|---|
| General Function
| Not Available |
| Specific Function
| DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Specific core component of RNA polymerase III which synthesizes small RNAs, such as 5S rRNA and tRNAs. May direct with other members of the subcomplex RNA Pol III binding to the TFIIIB-DNA complex via the interactions between TFIIIB and POLR3F. May be involved either in the recruitment and stabilization of the subcomplex within RNA polymerase III, or in stimulating catalytic functions of other subunits during initiation. Plays a key role in sensing and limiting infection by intracellular bacteria and DNA viruses. Acts as nuclear and cytosolic DNA sensor involved in innate immune response. Can sense non-self dsDNA that serves as template for transcription into dsRNA. The non-self RNA polymerase III transcripts, such as Epstein-Barr virus-encoded RNAs (EBERs) induce type I interferon and NF- Kappa-B through the RIG-I pathway.
|
| Pathways
|
- Cytosolic DNA-sensing pathway
- Epstein-Barr virus infection
- Purine metabolism
- Pyrimidine metabolism
- RNA polymerase
|
| Reactions
|
| Adenosine triphosphate + RNA → Pyrophosphate + RNA |
details
|
| Guanosine triphosphate + RNA → Pyrophosphate + RNA |
details
|
| Cytidine triphosphate + RNA → Pyrophosphate + RNA |
details
|
| Uridine triphosphate + RNA → Pyrophosphate + RNA |
details
|
|
| GO Classification
|
| Biological Process |
| termination of RNA polymerase III transcription |
| transcription elongation from RNA polymerase III promoter |
| positive regulation of innate immune response |
| regulation of transcription from RNA polymerase III promoter |
| positive regulation of interferon-beta production |
| defense response to virus |
| innate immune response |
| Cellular Component |
| DNA-directed RNA polymerase III complex |
| Molecular Function |
| DNA-directed RNA polymerase activity |
| DNA binding |
|
| Cellular Location
|
Not Available
|
| Gene Properties |
|---|
| Chromosome Location
| Not Available |
| Locus
| Not Available |
| SNPs
| Not Available |
| Gene Sequence
|
Not Available
|
| Protein Properties |
|---|
| Number of Residues
| Not Available |
| Molecular Weight
| Not Available |
| Theoretical pI
| Not Available |
| Pfam Domain Function
|
Not Available |
| Signals
|
Not Available
|
|
Transmembrane Regions
|
Not Available
|
| Protein Sequence
|
Not Available
|
| External Links |
|---|
| GenBank ID Protein
| Not Available |
| UniProtKB/Swiss-Prot ID
| Q9BUI4 |
| UniProtKB/Swiss-Prot Entry Name
| Not Available |
| PDB IDs
|
|
| GenBank Gene ID
| Not Available |
| GeneCard ID
| Not Available |
| GenAtlas ID
| Not Available |
| HGNC ID
| HGNC:30076 |
| References |
|---|
| General References
| Not Available |
