| Identification |
|---|
| HMDB Protein ID
| HMDBP11955 |
| Secondary Accession Numbers
| None |
| Name
| Alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 3 |
| Synonyms
|
- GalNAc alpha-2,6-sialyltransferase III
- ST6GalNAc III
- STY
- Sialyltransferase 7C
- ST6GalNAcIII
- SIAT7-C
|
| Gene Name
| ST6GALNAC3 |
| Protein Type
| Unknown |
| Biological Properties |
|---|
| General Function
| Not Available |
| Specific Function
| Involved in the biosynthesis of ganglioside GD1A from GM1B. Transfers CMP-NeuAc with an alpha-2,6-linkage to GalNAc residue on NeuAc-alpha-2,3-Gal-beta-1,3-GalNAc of glycoproteins and glycolipids. ST6GalNAcIII prefers glycolipids to glycoproteins (By similarity).
|
| Pathways
|
- Glycosphingolipid biosynthesis - ganglio series
- protein glycosylation
|
| Reactions
|
| Cytidine 5'-monophosphate-N-acetylneuraminic acid + alpha-N-acetylneuraminyl-2,3-beta-D-galactosyl-1,3-(N-acetyl-D-galactosaminyl)-glycoprotein → Cytidine monophosphate + alpha-N-acetylneuraminyl-2,3-beta-D-galactosyl-(2,6-alpha-N-acetylneuraminyl)-(N-acetyl-D-galactosaminyl)-glycoprotein |
details
|
| CMP-N-acetylneuraminate + GM1b → CMP + GD1a |
details
|
|
| GO Classification
|
| Biological Process |
| protein glycosylation |
| glycoprotein metabolic process |
| glycosylceramide metabolic process |
| Cellular Component |
| integral to Golgi membrane |
| Molecular Function |
| sialyltransferase activity |
|
| Cellular Location
|
Not Available
|
| Gene Properties |
|---|
| Chromosome Location
| 1 |
| Locus
| 1p31.1 |
| SNPs
| Not Available |
| Gene Sequence
|
Not Available
|
| Protein Properties |
|---|
| Number of Residues
| Not Available |
| Molecular Weight
| 24021.865 |
| Theoretical pI
| 9.252 |
| Pfam Domain Function
|
Not Available |
| Signals
|
Not Available
|
|
Transmembrane Regions
|
Not Available
|
| Protein Sequence
|
>>gi|229892275|ref|NP_001153483.1| alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 3 isoform 2 [Homo sapiens]
MACILKRKSVIAVSFIAAFLFLLVVRLVNEVNFPLLLNCFGQPGTKWIPFSYTYRRPLRT
HYGYINVKTQ
|
| External Links |
|---|
| GenBank ID Protein
| Not Available |
| UniProtKB/Swiss-Prot ID
| Q8NDV1 |
| UniProtKB/Swiss-Prot Entry Name
| Not Available |
| PDB IDs
|
Not Available |
| GenBank Gene ID
| Not Available |
| GeneCard ID
| Not Available |
| GenAtlas ID
| Not Available |
| HGNC ID
| HGNC:19343 |
| References |
|---|
| General References
| Not Available |
