Hmdb loader
Identification
HMDB Protein ID HMDBP11959
Secondary Accession Numbers None
Name DNA-binding protein SMUBP-2
Synonyms
  1. ATP-dependent helicase IGHMBP2
  2. Glial factor 1
  3. Immunoglobulin mu-binding protein 2
  4. GF-1
Gene Name IGHMBP2
Protein Type Unknown
Biological Properties
General Function Not Available
Specific Function 5' to 3' helicase that unwinds RNA and DNA duplices in an ATP-dependent reaction. Acts as a transcription regulator. Required for the transcriptional activation of the flounder liver-type antifreeze protein gene. Exhibits strong binding specificity to the enhancer element B of the flounder antifreeze protein gene intron. Binds to the insulin II gene RIPE3B enhancer region. May be involved in translation (By similarity). DNA-binding protein specific to 5'-phosphorylated single-stranded guanine-rich sequence related to the immunoglobulin mu chain switch region. Preferentially binds to the 5'-GGGCT-3' motif. Interacts with tRNA-Tyr. Stimulates the transcription of the human neurotropic virus JCV.
Pathways Not Available
Reactions
Adenosine triphosphate + Water → ADP + Phosphate details
GO Classification
Biological Process
translation
DNA repair
DNA replication
protein homooligomerization
negative regulation of transcription from RNA polymerase II promoter
transcription, DNA-dependent
DNA recombination
cell death
Cellular Component
growth cone
cytoplasm
nucleus
axon
ribonucleoprotein complex
Molecular Function
ATP-dependent 5'-3' RNA helicase activity
ribosome binding
metal ion binding
ATP binding
single-stranded DNA binding
zinc ion binding
ATP-dependent 5'-3' DNA helicase activity
tRNA binding
Cellular Location Not Available
Gene Properties
Chromosome Location 11
Locus 11q13.3
SNPs Not Available
Gene Sequence Not Available
Protein Properties
Number of Residues Not Available
Molecular Weight 109148.07
Theoretical pI 8.967
Pfam Domain Function
Signals Not Available
Transmembrane Regions Not Available
Protein Sequence
>>gi|119392094|ref|NP_002171.2| DNA-binding protein SMUBP-2 [Homo sapiens]
MASAAVESFVTKQLDLLELERDAEVEERRSWQENISLKELQSRGVCLLKLQVSSQRTGLY
GRLLVTFEPR
GenBank ID Protein Not Available
UniProtKB/Swiss-Prot ID P38935
UniProtKB/Swiss-Prot Entry Name Not Available
PDB IDs
GenBank Gene ID Not Available
GeneCard ID Not Available
GenAtlas ID Not Available
HGNC ID HGNC:5542
References
General References Not Available