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Identification
HMDB Protein ID HMDBP11987
Secondary Accession Numbers None
Name U5 small nuclear ribonucleoprotein 200 kDa helicase
Synonyms
  1. Activating signal cointegrator 1 complex subunit 3-like 1
  2. BRR2 homolog
  3. U5 snRNP-specific 200 kDa protein
  4. U5-200KD
Gene Name SNRNP200
Protein Type Unknown
Biological Properties
General Function Not Available
Specific Function Putative RNA helicase involved in the second step of RNA splicing. May promote one or more conformational changes in the dynamic network of RNA-RNA interactions in the spliceosome. Appears to catalyze an ATP-dependent unwinding of U4/U6 RNA duplices.
Pathways
  • Spliceosome
Reactions
Adenosine triphosphate + Water → ADP + Phosphate details
GO Classification
Biological Process
cis assembly of pre-catalytic spliceosome
Cellular Component
nucleoplasm
catalytic step 2 spliceosome
U5 snRNP
Molecular Function
nucleic acid binding
ATP binding
ATP-dependent helicase activity
Cellular Location Not Available
Gene Properties
Chromosome Location 2
Locus 2q11.2
SNPs Not Available
Gene Sequence Not Available
Protein Properties
Number of Residues Not Available
Molecular Weight 244505.465
Theoretical pI 6.067
Pfam Domain Function Not Available
Signals Not Available
Transmembrane Regions Not Available
Protein Sequence
>>gi|40217847|ref|NP_054733.2| U5 small nuclear ribonucleoprotein 200 kDa helicase [Homo sapiens]
MADVTARSLQYEYKANSNLVLQADRSLIDRTRRDEPTGEVLSLVGKLEGTRMGDKAQRTK
PQMQEERRAK
GenBank ID Protein Not Available
UniProtKB/Swiss-Prot ID O75643
UniProtKB/Swiss-Prot Entry Name Not Available
PDB IDs
GenBank Gene ID Not Available
GeneCard ID Not Available
GenAtlas ID Not Available
HGNC ID HGNC:30859
References
General References Not Available